Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products

Park, Hyun-Young; Kim, Jun Seok; Kwon, Yong Soo

doi:10.1007/s12272-010-0804-2

Cited by 9 publications

(10 citation statements)

References 18 publications

(16 reference statements)

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“…Woo et al reported that root bark of LB contained significant bacterial neuraminidase inhibitory activity [18]. It has recently been demonstrated that Lespedeza species can protect pancreatic β-cells from cytokine-induced damage in streptozotocin-induced diabetic mice [19,20], inhibit the formation of AGEs [21], and ameliorate endothelial dysfunction arising from MGO-induced glucotoxicity in diabetic retinopathy mode [13]. Chemical composition from LB extract includes stigmasterols, organic acids, terpenes, alkaloids, and flavonoids that have been screened for anticancer, anti-radiation, antioxidant, reducing blood sugar, and anti-inflammatory activity.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

Lee

Cho

et al. 2019

JCM

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Lespedeza bicolor (LB) is often used in traditional medicine to remove toxins, replenish energy stores, and regulate various symptoms of diabetes. This study aimed to explore the use of LB as a therapeutic to prevent diabetic nephropathy in methylglyoxal (MGO)-treated models in vitro and in vivo. Western blotting, immunostaining, and biochemical assays were used to obtain several experimental readouts in renal epithelial cells (LLC-PK1) and BALB/c mice. These include: production of reactive oxygen species (ROS), formation of advanced glycation end-products (AGEs), expression of receptor for advanced glycation end-products (RAGE), apoptotic cell death, glucose levels, fatty acid and triglyceride levels, expression of pro-inflammatory cytokines IL-1β and TNF-α, glyoxalase 1 (Glo1), and nuclear factor erythroid 2-related factor 2 (Nrf2). Pretreatment with LB significantly reduced MGO-induced cellular apoptosis, intracellular production of ROS, and formation of AGEs to ameliorate renal dysfunction in vitro and in vivo. Interestingly, administering LB in MGO-treated cells and mice upregulated the expression of Nrf2 and Glo1, and downregulated the expression of IL-1β and TNF-α. Moreover, LB reduced MGO-induced AGE accumulation and RAGE expression in the kidneys, which subsequently reduced AGE-RAGE interactions. Overall, LB ameliorates renal cell apoptosis and corrects renal dysfunction in MGO-treated mice. These findings extend our understanding of the pathogenic mechanism of MGO-induced nephrotoxicity and regulation of the AGE/RAGE axis by Lespedeza bicolor.

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Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

Lee

Cho

et al. 2019

JCM

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“…Note this is three times greater than the IC 50 of Onco A (87.88 ± 3.08 μM). Park et al [ 24 ] have reported that three compounds isolated from Lespedeza maximowiczi are actually more active than Onco A, with IC 50 values ranging from 5.4–20.6 μM.…”

Section: Resultsmentioning

confidence: 99%

Oncocalyxone A Functions As an Anti-Glycation Agent In Vitro

Melo¹,

Santos

Lemos

et al. 2015

PLoS ONE

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Advanced glycation endproducts (AGE) are the result of post-translational changes to proteins, which ultimately compromise their structure and/or function. The identification of methods to prevent the formation of these compounds holds great promise in the development of alternative therapies for diseases such as diabetes. Plants used in traditional medicine are often rich sources of anti-glycation agents. Therefore, in this study, we investigated the anti-glycation activity of one such compound, Oncocalyxone A (Onco A). Using spectrofluorimetric techniques, we determined that Onco A inhibits AGE formation in a concentration-dependent manner. Its IC50 value (87.88 ± 3.08 μM) was almost two times lower than the standard anti-glycation compound aminoguanidine (184.68 ± 4.85 μM). The excellent anti-glycation activity of Onco A makes it an exciting candidate for the treatment of diseases associated with excessive accumulation of AGE. However, additional studies are necessary to identify its mechanism of action, as well as the in vivo response in suitable model organisms.

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“…As a physiologically active substance of L. cuneata G. Don, β‐sitosterol, quercetin, kaempferol, pinitol, avicularin, juglanin, and trifolin (Matsuura, Iinuma, Ito, Takami, & Kagei, ) have been identified. In addition, the hot water and ethanol extract of L. cuneata G. Don have been reported to have antioxidative effect through its flavone glycosides (Deng, Chang, & Zhang, ; Park, Kim, & Kwon, ). Even though there are a rich of the natural biological resource in L. cuneata G. Don, the specific study on the potential of the cosmeceutical composition using L. cuneata G. Don is still insufficient.…”

Section: Introductionmentioning

confidence: 99%

Antiwrinkle and antimelanogenesis activity of the ethanol extracts of Lespedeza cuneata G. Don for development of the cosmeceutical ingredients

Lee

Park

2018

Food Science & Nutrition

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To develop the ingredient with the cosmeceutical function, the antiwrinkle and antimelanogenesis effects of the ethanol extract of Lespedeza cuneata G. Don were investigated. DPPH radical scavenging activity was significantly increased with the extract of L. cuneata G. Don. Cell viability on CCD986Sk human fibroblast was also increased by the ethanol extract of L. cuneata G. Don. The inhibitory function of the extract of L. cuneata G. Don on collagenase, elastase, and tyrosinase was evaluated. Protein expression level of Claudin‐1, Occludin, and ZO‐1 was up‐regulated in HaCaT human keratinocyte by the extract of L. cuneata G. Don. In addition, the extract of L. cuneata G. Don inhibited melanin synthesis in B16F10 murine melanoma cells by decreasing MITF, TRP1, and TRP2 protein levels and increasing the phosphorylated Erk and Akt. Thus, these findings would be useful for developing the new cosmeceutical formulations based on the extract of L. cuneata G. Don.

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Two new dihydrofuranoisoflavanones from the leaves of Lespedeza maximowiczi and their inhibitory effect on the formation of advanced glycation end products

Cited by 9 publications

References 18 publications

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

Therapeutic Potential of Lespedeza bicolor to Prevent Methylglyoxal-Induced Glucotoxicity in Familiar Diabetic Nephropathy

Oncocalyxone A Functions As an Anti-Glycation Agent In Vitro

Antiwrinkle and antimelanogenesis activity of the ethanol extracts of Lespedeza cuneata G. Don for development of the cosmeceutical ingredients

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