Two New Derivatives of Griseofulvin from the Mangrove Endophytic FungusNigrosporasp. (Strain No. 1403) fromKandelia candel(L.) Druce

Abstract

Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybostrycin (6), were isolated from the marine endophytic fungus NIGROSPORA sp. (No. 1403) collected from the South China Sea. The structures were elucidated by spectroscopic methods, 1D, 2D NMR, and HREIMS. Compounds 5 and 6 showed moderate antitumor and moderate antimicrobial activity.

Antimicrobial dihydrobenzofurans and xanthenes from a foliar endophyte of Pinus strobus

“…Benzofurans and their derivatives are commonly reported as metabolites of both bacteria and fungi, including endophytes of trees (Findlay et al, 1997;Richardson et al, 2014;Xia et al, 2011). A wide array of biological activities have been reported from these compounds including antiproliferative (Chen et al, 2002;Zeng et al, 2012), antitubercular (Huang et al, 2008), antiinsectan (Findlay et al, 1997) and antimicrobial (Boonphong et al, 2007).…”

Secondary Metabolites of a Mangrove Endophytic Fungus Aspergillus terreus (No. GX7-3B) from the South China Sea

“…Marine fungi have been proven to be an important source of structurally novel and bioactive secondary metabolites [1,2,3,4,5], and it is well-known that under various culture conditions, many marine fungi can produce various secondary metabolites, which possess unique structures and bioactivities [6,7]. Aspergillus terreus (No.…”

Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

“…Bostrycin ( 1 , Figure 1), a natural tetrahydroanthraquinone compound, was isolated from the mangrove endophytic fungus No. 1403 collected from the South China Sea, as well as three bostrycin analogues ( 2 – 4 , Figure 1) [12,13,14]. The originally proposed structure of bostrycin was identified by interpretation of spectral date (IR, UV, MS, 1 H NMR, 13 C NMR) [15,16,17], and then revised by Kelly and his co-workers [18] on the basis of the total synthesis of (+/−)-bostrycin and an X-ray crystal structure of the O -isopropylidene derivative.…”

“…Subsequently, Larsen’s group [19] revised the absolute configuration of (−)-bostrycin through an elegant asymmetric synthesis of (+)-bostrycin. Our recent studies have shown that bostrycin has broad-spectrum antitumor activity [13,14,20,21]. Bostrycin can induce apoptosis of breast cancer cells through Akt/FOXO pathway, revealing it is a potent apoptosis inducer [20].…”