Two new coumarins from Toddalia aculeata

Vasorelaxing Properties and Bio-Guided Fractionation ofCedrelopsis grevei

“…Compounds 1±5 were identified as coumarins by interpretation of spectral data and comparison with those described in the literature [6], [7], [8], [9], [10], [11]. Their presence in C. grevei is reported here for the first time.…”

One‐pot Synthesis of Fused Dipyranocoumarins from Dihydroxycoumarins and Propargyl Chlorides under Microwave Irradiation

“…The yields of the products of this later experiment are almost the same as in the reaction under method A and MW irradiation for 3 h, while the reflux for 7 days under method A led only to product 6b in low yield (Table , entries 6, 7). The compound 8a is the natural product norbraylin , which is a component of the hydroalcoholic extract of trunk bark of Cedrelopsis gravei presenting vasorelaxing activity [28b]. Norbraylin was tested also and had low antitumor activity [28c].…”

New prenylated coumarins from the stems of Toddalia asiatica

“…The characteristic absorption bands at n max 1727, 1600, 1500, and 1466 cm À1 in the IR spectrum of 1 suggested the presence of ester and aromatic moieties. The 1D NMR spectra of 1 displayed signals for a 5,7-dimethoxy-8-substituted coumarin unit [d H 7.94 (1H, d, J ¼ 9.7 Hz, H-4), 6.29 (1H, s, H-6), 6.11 (1H, d, J ¼ 9.7 Hz, H-3), 3.92 (3H, s, 5-OCH 3 ), and 3.91 (3H, s, 7-OCH 3 ); d C 161.4 (C, C-7), 160.6 (C, C-2), 157.4 (C, C-5), 154.9 (C, C-9), 138.8 (CH, C-4), 111.1 (CH, C-3), 107.0 (C, C-8), 103.9 (C, C-10), 90.4 (CH, C-6), 56.4 (CH 3 , 7-OCH 3 ), and 56.1 (CH 3 , 5-OCH 3 )] as in co-isolated compounds 8-11, [12][13][14][15][16] which was further conrmed by the HMBC correlations (Fig. 2).…”

“…The known compounds, gleinadiene (8), 12 toddalenone (9), 13 8-geranyloxy-5,7-dimethoxycoumarin (10), 14 5,7,8-trimethoxycoumarin (11), [14][15][16] toddaculin (12), 13 32 8-acetonyldihydronitidine (34), 33 8-acetonyldihydrochelerythrine (35), 34 decarine (36), 34 4-methoxy-N-methyl-2-quinolone (37), 35 g-fagarine (38), 35 haplopine (39), 36 and skimmianine (40), 36 were identied by comparison of their spectroscopic data with those reported in the literature. The 1 H and 13 C NMR data of all known compounds are provided in Tables S2.1-S2.10 (see ESI †).…”