Two New Compounds from the Fungus Xylaria nigripes

Abstract

In the process of discovering more neural-system-related bioactive compounds from Xylaria nigripes, xylariamino acid A (1), a new amino acid derivative, and a new isovaleric acid phenethyl ester (2) were isolated and identified. Their structures and absolute configurations were determined by analyses of IR, HRESIMS, NMR spectroscopic data, and gauge-independent atomic orbital (GIAO) NMR calculation, as well as electronic circular dichroism (ECD) calculation. The isolated compounds were evaluated for their neuroprotective effects against damage to PC12 cells by oxygen and glucose deprivation (OGD). Compounds 1 and 2 can increase the viability of OGD-induced PC12 cells at all tested concentrations. Moreover, compound 2 (1 μmol L−1) can significantly reduce the percentage of apoptotic cells.

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

“…(Xylariaceae). The fungus was collected from Ailao Moutain, China [ 73 ]. Two new spirocyclic pyrrole alkaloids, including xylapyrrosides A ( 226 ) and B ( 227 ), were isolated from the Wuling Powder-derived fungus Xylaria nigripes .…”

“…Sacc. (Xylariaceae), significantly reduced the percentage of apoptotic cells at a concentration of 1 µM [ 73 ]. One new metabolite, 3,7-dimethyl-9-(-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl) nona-1,6-dien-3-ol ( 402 ), was isolated from a Taxus mairei -derived strain.…”

ANTIBACTERIAL ACTIVITY AND VIRULENCE FACTORS INHIBITION BY Xylaria sp. (Xylariaceae, Ascomycota): A STUDY OF BIOACTIVE POTENTIAL

“…Sterile PDA was used as a control, and all cultures were incubated in triplicates for 10 days. Additionally, a liquid culture of the fungus was performed in a 500 mL Erlenmeyer flask supplemented with rice substrate (100 g) in 100 mL of sterile water, following the methodology described by Long et al (2023) with some modifications. They were then incubated for 60 days at 25 ± 2 °C under alternating light and dark conditions (30 days each).…”