Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

Abstract

Two new arylnaphthalide lignans, procumphthalide A (1) and 4-O-beta-D-glucopyranosyl-(1"'-->2")-beta-D-apiofuranosyldiphyllin, named procumbenoside B (2), along with cilinaphthalide B (3) and several other known compounds were isolated from the methanolic extracts of Justicia procumbens. By using NMR and other spectral methods, the structures of 1 and 2 were elucidated. Cilinaphthalide B (3), justicidin A (4), and taiwan E methyl ether (5) were shown to have an antiplatelet effect in human plateletrich plasma. In human citrated PRP, 5 showed a strong inhibitory effect on platelet aggregation induced by adrenaline in a concentration-dependent manner, with an IC(50) value of about 27.6 microM.

Recent advances in research on lignans and neolignans

“…Neglignans A (86), B (87), and E-G (88)(89)(90) were isolated from the acetone extract of the stem of Schisandra neglecta. Neglignans A and B are the rst dibenzocyclooctadiene lignans bearing a carboxyl group at C-4.…”

A Combined Transition‐Metal‐Catalyzed and Photopromoted Process: Synthesis of 2,3‐Fused 4‐Phenylnaphthalen‐1‐yl Carboxylates from 1,7‐Diaryl‐1,6‐diynes

“…9‐Phenyl‐1,3‐dihydronaphtho[2,3‐c]furan‐4‐ol ( 1 ) is the basic skeleton of arylnaphthalide lignan natural products, such as diphyllin,1 justicidin A,2 taiwanin E,3 and neojusticidin A (Figure 1). 4 Members of this lignan family display significant biological activities, including antiplatelet,5 anti‐inflammatory,6 antiviral,7 and cytotoxic activities 8. In addition, closely related natural and synthetic molecules with diverse significant biological activities are also known, for example, antitumor/antimitotic podophyllotoxin, an anti‐HIV agent, and a 5‐lipoxygenase inhibitor (Figure 1).…”

Application of a sensitive and specific LC–MS/MS method for determination of chinensinaphthol methyl ether in rat plasma for a bioavailability study

“…Bioassay results revealed that CME exhibited antitumor [4,7,9], anti-platelet [5,10] and antiviral activities [8]. In the on-going studies, CME was selected as one of the chemical markers for quality control of Justicia procumbens raw material [11].…”