Recent advances in research on lignans and neolignans

Teponno, Rémy Bertrand; Kusari, Souvik; Spiteller, Michael

doi:10.1039/c6np00021e

Cited by 375 publications

(262 citation statements)

References 200 publications

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“…One of the most important coumarins found in noni plant is scopoletin (6-methoxy-7-hydroxycoumarin), which has shown a notable effect in the treatment of obesity and metabolic dysfunction [49,55]. Lignans and neolignans are present in many plants, being a large group of natural products derived from the oxidative coupling of two C6-C3 units [75]. The most important lignans isolated from noni fruit are americanin A, americanol A, episesamin 2,6-dicatechol, isoprincepin, lirioresinol, lirioresinol B dimethyl ether, morindolin, and 3,3’-bisdemethypinoresinol.…”

Section: Morinda Citrifolia Linn (Noni)mentioning

confidence: 99%

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

et al. 2017

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Cultural and economic shifts in the early 19th century led to the rapid development of companies that made good profits from technologically-produced commodities. In this way, some habits changed in society, such as the overconsumption of processed and micronutrient-poor foods and devices that gave rise to a sedentary lifestyle. These factors influenced host-microbiome interactions which, in turn, mediated the etiopathogenesis of “new-era” disorders and diseases, which are closely related, such as obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, hypertension, and inflammatory bowel disease, which are characterized by chronic dysregulation of metabolic and immune processes. These pathological conditions require novel and effective therapeutic approaches. Morinda citrifolia (noni) is well known as a traditional healing plant due to its medicinal properties. Thus, many studies have been conducted to understand its bioactive compounds and their mechanisms of action. However, in obesity and obesity-related metabolic (dysfunction) syndrome, other studies are necessary to better elucidate noni’s mechanisms of action, mainly due to the complexity of the pathophysiology of obesity and its metabolic dysfunction. In this review, we summarize not only the clinical effects, but also important cell signaling pathways in in vivo and in vitro assays of potent bioactive compounds present in the noni plant which have been reported in studies of obesity and obesity-associated metabolic dysfunction.

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Section: Morinda Citrifolia Linn (Noni)mentioning

confidence: 99%

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

et al. 2017

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“…Plant-derived antimicrobial compounds belong to an exceptionally wide diversity of classes, including terpenoids (Bhalodia et al, 2011), lignans (Teponno et al, 2016), alkaloids and peptides (Bhatter et al, 2016), phenolic compounds (Heleno et al, 2015) and coumarins (Bhatter et al, 2015, 2016). All of the aforementioned compounds are regarded as secondary metabolism products in plants, not strictly required for their survival, but usually conferring a positive effect for its use as medicinal purposes (Harborne, 1997; Kroymann, 2011).…”

Section: Introductionmentioning

confidence: 99%

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

Pereira

Jandú

et al. 2017

Front. Microbiol.

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Commiphora leptophloeos is a plant specie usually known for its medicinal purposes in local communities in Northeast Brazil. In order to evaluate its therapeutic potential, we aimed to determine the phytochemical and antimicrobial properties of C. leptophloeos extracts. Thin Layer Chromatography (TLC) was able to detect the presence of phenolic compounds, flavonoids and reducing sugars. Three phenolic compounds were identified by HPLC and described as Gallic, Chlorogenic and Protocatechuic acids. On the other hand, H1NMR analysis revealed the presence of hinokinin, a bioactive lignan further characterized in the present work. The minimum inhibitory concentration (MIC) values for hinokinin ranged from 0.0485 to 3.125 mg/mL in different S. aureus clinical isolates and showed a bactericidal activity against MRSA isolated from blood (MMC 0.40 mg/mL) and postoperative secretion (MMC = 3.125 mg/mL). C. leptophloeos extracts also showed antimicrobial activity against Mycobacterium species such as M. smegmatis (MIC = 12.5 mg/mL) and M. tuberculosis (MIC = 52 mg/mL). Additionally, we determined the toxicity of C. leptophloeos by in vitro HC50 tests with hemolytic activity detected of 313 ± 0.5 μg/mL. Our results showed that C. leptophloeos possesses inhibitory properties against MRSA as well as several other clinically important microorganisms. Furthermore, the present work is the first report of the presence of hinokinin in Commiphora genus.

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“…Plant lignans and derivatives are one of the most extensively distributed constituents in the plant kingdom 16 . Several reports have demonstrated that these compounds exhibit a wide range of biological activities including cardiovascular, antiinflammatory, antimicrobial, antiviral, anticancer, immunosuppressive, insecticidal, anti-feeding, and anti-oxidant effects 10 .…”

Section: Fig 3: Log Concentration Versus % Dpph Scavenging Effect Ofmentioning

confidence: 99%

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2017

IJPSR

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ABSTRACT:The roots of Landolphia heudelotti are employed in traditional medicine for the treatment of a plethora of ailments. In this study, the antioxidant activity and bioactive constituents of the methanol root extract were investigated. Fourteen known compounds including a lignan, neolignans, sesquilignans, a coumarin and an aromadendrane sesquiterpene were isolated from the root extract. The structure elucidation of compounds was performed based on mass spectral and NMR spectroscopic data and by comparison with literature. The crude extract had a high total antioxidant Capacity of 108.8 ± 14.52 mg/g of dried extract (ascorbic acid equivalent) and also demonstrated significant DPPH free radical scavenging activity (IC 50 = 6.956 ± 0.8121 µg/mL). The extract also had a total phenolic content of 98.14 ± 14.70 mg/g of dried extract (tannic acid equivalent). The results of this study have given scientific credence to the use of L. heudelotti roots in traditional medicine. This is the first report of these phyto-constituents from L. heudelotti.

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Recent advances in research on lignans and neolignans

Cited by 375 publications

References 200 publications

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction

Commiphora leptophloeos Phytochemical and Antimicrobial Characterization

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