Two Neglected Biologic Risk Factors in Bone Grafting and Implantology: High Low-Density Lipoprotein Cholesterol and Low Serum Vitamin D

Choukroun, Joseph; Khoury, Georges; Khoury, Fouad; Russe, Philippe; Testori, Tiziano; Komiyama, Y; Sammartino, Gilberto; Palacci, Patrick; Tunalı, Mustafa; Choukroun, Elisa

doi:10.1563/aaid-joi-d-13-00062

Cited by 45 publications

(44 citation statements)

References 41 publications

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“…The causes of early implant failure are not fully clarified and an association between vitamin D and dental implant osseointegration has not been investigated properly [8, 13–16]. Some recent animal studies in rodents demonstrated a relationship between vitamin D supplementation and an increased bone to implant contact/volume after implant placement [14, 34, 35].…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants from different manufacturers in the molar region of the mandible. In the case of bone grafting in the first patient, all implants were placed in a two-stage procedure. All implants had to be removed within 15 days after implant placement. Vitamin D serum levels were measured: Both patients showed a vitamin D deficiency (serum vitamin D level <20 μg/l). After vitamin D supplementation, implant placement was successful in both patients. Prospective, randomized clinical trials must follow to affirm the relationship between vitamin D deficiency, osteoimmunology, and early implant failure.

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Section: Discussionmentioning

confidence: 99%

“…A current review article demands the investigation of vitamin D deficiency in the context of dental implant failures [16]. To address this demand, the present case reports raised the question if vitamin D deficiency influences implant survival in the early stages of healing.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in early implant failure: two case reports

et al. 2016

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“…114 This vitamin can stimulate osteoblast bone matrix production, coupling bone resorption to formation, and optimize bone remodeling. 115 It increases calcium absorption in the intestine leading to a reduction in PTH secretion and lower systemic bone resorption 114,116,117 with a possible inhibition of osteoclastogenesis. 118 1,25-dyhydroxy vitamin D3 can stimulate bone resorption by binding to osteoblast vitamin D receptors and by altering the balance between RANKL and OPG.…”

Section: Cholesterol and Fatty Acidsmentioning

confidence: 99%

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Ínsua

Monje

Wang

et al. 2017

J Biomedical Materials Res

190

188

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Despite the growing number of publications in the field of implant dentistry, there are limited studies to date investigating the biology and metabolism of bone healing around dental implants and their implications in peri-implant marginal bone loss. The aim of this review article is to provide a thorough understanding of the biological events taking place during osseointegration and the subsequent early and late phases of bone remodeling around dental implants. An update on the coupling mechanism occurring during bone resorption-bone remodeling is provided, focused on the relevance of the osteocytes, bone lining cells and immune cells during bone maintenance. An electronic and manual literature search was conducted by three independent reviewers in several databases, including MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register databases for articles up to September 2016 with no language restriction. Local bone metabolism is subject to signals from systemic calcium-phosphate homeostasis and bone remodeling. Three areas of interest were reviewed due to recent reported compromises in bone healing including the putative effects of (1) cholesterol, (2) hyperlipidemia, and (3) low vitamin D intake. Moreover, the prominent influence of osteocytes and immune cells is discussed as being key regulators during dental implant osseointegration and maintenance. These cells are of crucial importance in the presence of biofilm accumulation and their associated byproducts that leads to hard and soft tissue breakdown; the so called peri-implantitis. Factors that could negatively impact osteoclastogenesis or osteal macrophage activation should be monitored in future research including implant placement/torque protocols, bone characteristics, as well as meticulous maintenance programs to favor osseointegration and future long-term stability and success of dental implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2075-2089, 2017.

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“…This vitamin stimulates the osteoblastic bone production, switches the process of bone resorption to bone formation, optimizes bone remodeling, stimulates bone metabolism and alkaline phosphatase activity, and protects bone mass by increasing the bone matrix proteins (osteocalcin and osteopontin) . It increases calcium absorption in the intestine and leads to a decrease in the parathyroid hormone secretion and systemic bone resorption, by possible inhibition of osteoclastogenesis . It has been reported that vitamin D plays important role in the regulation of bone metabolism and many biological and metabolic processes, and vitamin D deficiency may play an important role in reducing bone mineral density and total mineral content .…”

Section: Introductionmentioning

confidence: 99%

“…4,5 It increases calcium absorption in the intestine and leads to a decrease in the parathyroid hormone secretion and systemic bone resorption, by possible inhibition of osteoclastogenesis. 6,7 It has been reported that vitamin D plays important role in the regulation of bone metabolism and many biological and metabolic processes, and vitamin D deficiency may play an important role in reducing bone mineral density and total mineral content. 8 In addition, vitamin D deficiency may represent a risk factor against bone healing and osseointegration.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases

Acipinar

Hendek

Olgun

et al. 2019

Clin Implant Dent Rel Res

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Background There are limited studies to date investigating vitamin D and fibroblast growth factor (FGF)‐23 in different peri‐implant conditions. Purpose To evaluate the peri‐implant sulcus fluid (PISF) FGF‐23 and 25‐hydroxy‐vitamin D3 (25(OH)D3) levels in peri‐implant health and diseases. Materials and Methods A total of 90 dental implant sites (peri‐implant healthy group [n = 30], peri‐implant mucositis group [n = 30], and peri‐implantitis group [n = 30]) in 53 participants were included in the study. Probing depth (PD), clinical attachment level (CAL), suppuration (S), modified plaque index (mPI), gingival index (GI), modified sulcus bleeding index (mSBI), and keratinized mucosa width (KMW) were recorded as clinical parameters, and PISF samples were obtained. FGF‐23 and 25(OH)D3 levels were analyzed by enzyme‐linked immunosorbent assay. Results There were no statistically significant differences in FGF‐23 concentrations among the groups (P > .05). The 25(OH)D3 concentration was significantly lower in peri‐implantitis group compared with the other two groups (P < .05). The mean total amount of FGF‐23 in the peri‐implantitis group was significantly higher than the peri‐implant healthy group whereas 25(OH)D3 total amount was significantly lower in the peri‐implantitis group than the peri‐implant healthy group. The 25(OH)D3 concentration was significantly negatively correlated with CAL, PD, mPI, S, GI, and mSBI and statistically significant relationship was found between FGF‐23 total amount and these clinical parameters (P < .05). There was a negligible positive correlation between 25(OH)D3 and FGF‐23 concentrations (τ = 0.169; P = .018). Conclusion Within the limitations of this study, it can be concluded that FGF‐23 and vitamin D seems to affect peri‐implant bone health, and further studies are needed to explain the association between FGF‐23 and 25(OH)D3 in peri‐implant conditions.

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Two Neglected Biologic Risk Factors in Bone Grafting and Implantology: High Low-Density Lipoprotein Cholesterol and Low Serum Vitamin D

Cited by 45 publications

References 41 publications

Vitamin D deficiency in early implant failure: two case reports

Vitamin D deficiency in early implant failure: two case reports

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases

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Two Neglected Biologic Risk Factors in Bone Grafting and Implantology: High Low-Density Lipoprotein Cholesterol and Low Serum Vitamin D

Cited by 45 publications

References 41 publications

Vitamin D deficiency in early implant failure: two case reports

Vitamin D deficiency in early implant failure: two case reports

Basis of bone metabolism around dental implants during osseointegration and peri‐implant bone loss

Evaluation of FGF‐23 and 25(OH)D3 levels in peri‐implant sulcus fluid in peri‐implant health and diseases

Contact Info

Product

Resources

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Evaluation of FGF‐23 and 25(OH)D₃ levels in peri‐implant sulcus fluid in peri‐implant health and diseases