Two Natural Recombination gave rise to the Coxsackievirus B3 GV that triggered outbreaks in China in 2006 - 2012

Wang, Hua; Qian, Yongjiang; Chen, Qian; Dai, Chun; Shen, Han‐Xi

doi:10.1016/j.medmal.2020.09.008

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…We allocated the worldwide CVB3 variants to twenty-three different evolutionary recombinant lineages based on non-capsid sequences. Several previous studies showed that Chinese CVB3 showed the highest similarity with the parental CVB3 in the P1 region, with the E25 strain in the P2-P3 region, and other strains of CVB3 showed similarity with CVB5 in the P3 region [ 54 , 55 ], which is consistent with our study. However, it remains unclear whether there are substantial differences in recombination frequencies between different EVs such as echoviruses, and whether CVB5 plays a major role in the natural recombination of CVB3.…”

Section: Discussionsupporting

confidence: 92%

Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide

Yang

Yan

Song

et al. 2022

Virol J

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Background Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has not been systematically analyzed with regard to whole-genome diversity and recombination. Therefore, this study was undertaken to systematically examine the genetic characteristics of CVB3 based on its whole genome. Methods We combined CVB3 isolates from our national HFMD surveillance and global sequences retrieved from GenBank. Phylogenetic analysis was performed to examine the whole genome variety and recombination forms of CVB3 in China and worldwide. Results Phylogenetic analysis showed that CVB3 strains isolated worldwide could be classified into clusters A–E based on the sequence of the entire VP1 region. The predominant CVB3 strains in China belonged to cluster D, whereas cluster E CVB3 might be circulated globally compared to other clusters. The average nucleotide substitution rate in the P1 region of CVB3 was 4.82 × 10–3 substitutions/site/year. Myocarditis was more common with cluster A. Clusters C and D presented more cases of acute flaccid paralysis, and cluster D may be more likely to cause HFMD. Multiple recombination events were detected among CVB3 variants, and there were twenty-three recombinant lineages of CVB3 circulating worldwide. Conclusions Overall, this study provides full-length genomic sequences of CVB3 isolates with a wide geographic distribution over a long-term time scale in China, which will be helpful for understanding the evolution of this pathogen. Simultaneously, continuous surveillance of CVB3 is indispensable to determine its genetic diversity in China as well as worldwide.

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Section: Discussionsupporting

confidence: 92%

Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide

Yang

Yan

Song

et al. 2022

Virol J

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“…Recombination occurs between divergent positive-sense RNA viruses [9,15,16], and is a common phenomenon [7,9,11,[14][15][16]. However, the recombination of HEV has rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

A quadruple recombination event discovered in hepatitis E virus

et al. 2021

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Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but the recombination of HEV has rarely been reported. In the present study, phylogenetic and recombination analyses were performed on 557 complete HEV genomes in GenBank. A potentially signi cant quadruple recombination event was identi ed by recombination detection analysis. The recombinant progeny virus HEV_32_Manchester_301214 was produced by recombination between the major parent HEPAC-44 and the minor parent HE-JA15-1335, thereby re ecting inter-genotype recombination.HEV_32_Manchester_301214 and HEPAC-44 belong to genotype 3, while HE-JA15-1335 belongs to genotype 1, and these three strains have all been separated from humans. Three breakpoints of the four recombination events occurred in the ORF2 region, while another occurred in the ORF1 region. This quadruple recombination event was con rmed by phylogenetic analysis. The genotype, host and the recombination regions of the three strains were analyzed. These results of the analyses provide valuable suggestions for future research on HEV diversity.

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Whole-Genome Analysis of Coxsackievirus B3 Reflects Its Genetic Diversity in China and Worldwide

Yang

Yan

Song

et al. 2021

Preprint

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Background Coxsackievirus B3 (CVB3) has emerged as an active pathogen in myocarditis, aseptic meningitis, hand, foot, and mouth disease (HFMD), and pancreatitis, and is a heavy burden on public health. However, CVB3 has not been systematically analyzed with regard to whole-genome diversity and recombination. Therefore, this study was undertaken to systematically examine the genetic characteristics of CVB3 based on its whole genome. Methods We combined CVB3 isolates from our national HFMD surveillance and global sequences retrieved from GenBank. Phylogenetic analysis was performed to examine the whole genome variety and recombination forms of CVB3 in China and worldwide. Results Phylogenetic analysis showed that CVB3 strains isolated worldwide could be classified into groups A–E based on the sequence of the entire VP1 region. The predominant CVB3 strains in China belonged to group D, whereas group E CVB3 might be circulated globally compared to other groups. The average nucleotide substitution rate in the P1 region of CVB3 was 4.82 × 10−3 substitutions/site/year. Myocarditis was more common with group A. Groups C and D presented more cases of acute flaccid paralysis, and group D may be more likely to cause HFMD. Multiple recombination events were detected among CVB3 variants, and there were twenty-three recombinant lineages of CVB3 circulating worldwide. Conclusions Overall, this study provides full-length genomic sequences of CVB3 isolates with a wide geographic distribution over a long-term time scale in China, which will be helpful for understanding the evolution of this pathogen. Simultaneously, continuous surveillance of CVB3 is indispensable to determine its genetic diversity in China as well as worldwide.

show abstract

Two Natural Recombination gave rise to the Coxsackievirus B3 GV that triggered outbreaks in China in 2006 - 2012

Cited by 4 publications

References 21 publications

Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide

Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide

A quadruple recombination event discovered in hepatitis E virus

Whole-Genome Analysis of Coxsackievirus B3 Reflects Its Genetic Diversity in China and Worldwide

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