Two Major Serologic Events in a Successful Cardiac Transplant Recipient— Circumvention of Hyperacute Rejection Despite a Positive Donor T Lymphocyte Crossmatch and Late Appearance of Probable Antiidiotypic Antibody

Chronic rejection is the major threat to both heart and renal allograft survival. We have explored the possibility that some patients with anti-donor HLA antibodies (Ab1) develop specific anti-idiotypic antibodies (Ab2) which suppress the production of Ab1, and subsequently, the progression of chronic rejection. Analysis of Ab2 in sera obtained from Ab1 producers showed that 22% of heart and 18% of kidney recipients produced Ab2. The 4- and 5-year actuarial graft survivals in Ab2 producers were 100% and 83%, respectively, compared to 57% in patients who formed Ab1 but not Ab2 (p < 0.004). Patients carrying the DR2 alleles, DRB1*1501, *1502 or *1601 were at a lower risk of producing anti-donor HLA antibodies.

show abstract

Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients

Reed

Cohen

et al. 1993

Immunol Res

View full text Add to dashboard Cite

show abstract

Early cardiac allograft failure after orthotopic heart transplantation

Hauptman

Aranki

Mudge

et al. 1994

American Heart Journal

View full text Add to dashboard Cite

Immunologic aspects of rejection

Marboe

Buffaloe

Fenoglio

1990

Progress in Cardiovascular Diseases

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Two Major Serologic Events in a Successful Cardiac Transplant Recipient— Circumvention of Hyperacute Rejection Despite a Positive Donor T Lymphocyte Crossmatch and Late Appearance of Probable Antiidiotypic Antibody

Cited by 10 publications

References 0 publications

Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients

Anti-idiotypic antibodies specific for HLA in heart and kidney allograft recipients

Early cardiac allograft failure after orthotopic heart transplantation

Immunologic aspects of rejection

Contact Info

Product

Resources

About