Early cardiac allograft failure after orthotopic heart transplantation

Hauptman, Paul J.; Aranki, Sary F.; Mudge, Gilbert H.; Couper, Gregory S.; Loh, Evan

doi:10.1016/0002-8703(94)90523-1

Cited by 35 publications

(13 citation statements)

References 18 publications

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“…Most of them are concerned with the successful use of MCS in conjunction with RHF [10,11,12,14,15]. Others report the treatment of PGF with LVAD [9,18] or with BVAD [16,17,19,20]. On the basis of an evaluation of more than 200 cases with MCS in our hospital [2,4,5,6,7] the advantages and disadvantages of the individual systems could be proven.…”

Section: Discussionmentioning

confidence: 99%

Differential indication for mechanical circulatory support following heart transplantation

Pa¹,

El‐Banayosy

Minami

et al. 2001

Intensive Care Med

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Section: Discussionmentioning

confidence: 99%

Differential indication for mechanical circulatory support following heart transplantation

Pa¹,

El‐Banayosy

Minami

et al. 2001

Intensive Care Med

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“…Another limitation is the definition of early graft failure. We used criteria commonly referred to in the literature (6,47), but we defined the time at which early graft failure was diagnosed more restrictively. CONCLUSION Elevated levels of both cTnT and cTnI were found in donors with ongoing impairment of heart function, even when direct inspection and hemodynamic and echocardiographic measurements showed no evidence of impaired heart function.…”

Section: Limitations Of This Studymentioning

confidence: 99%

Value of Cardiac Troponin I and T for Selection of Heart Donors and as Predictors of Early Graft Failure 1

Potapov

Ivanitskaia

Loebe³

et al. 2001

Transplantation

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“…In seeking to understand why endogenous memory CD8 T cells within unprimed mice are unable to mediate cardiac allograft rejection, we realized that the donor grafts in these studies were subjected to minimal cold ischemic storage (0.5 h) prior to transplant, a protocol that is not only clinically unrealistic, but may minimize the activity of early graft infiltrating endogenous memory T cells and maximize the efficacy of tolerance-inducing strategies. Considering the critical role of ischemia-reperfusion injury (IRI) on allograft outcome (18)(19)(20)(21)(22)(23)(24)(25), we tested the impact of increased duration of cold ischemic storage on early endogenous memory CD8 T cell infiltration and functions in cardiac allografts. Our results reveal a direct association between increased duration of cold ischemia and numbers of endogenous memory CD8 T cells in the graft within 48 h of reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Endogenous Memory CD8 T Cells Directly Mediate Cardiac Allograft Rejection

Iida

Abe

et al. 2014

American Journal of Transplantation

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Differences in levels of environmentally induced memory T cells that cross-react with donor MHC molecules are postulated to account for the efficacy of allograft tolerance inducing strategies in rodents versus their failure in nonhuman primates and human transplant patients. Strategies to study the impact of donor-reactive memory T cells on allografts in rodents have relied on the pre-transplant induction of memory T cells cross-reactive with donor allogeneic MHC molecules through recipient viral infection, priming directly with donor antigen, or adoptive transfer of donor-antigen primed memory T cells. Each approach accelerates allograft rejection and confers resistance to tolerance induction, but also biases the T cell repertoire to strong donor-reactivity. The ability of endogenous memory T cells within unprimed mice to directly reject an allograft is unknown. Here we show a direct association between increased duration of cold ischemic allograft storage and numbers and enhanced functions of early graft infiltrating endogenous CD8 memory T cells. These T cells directly mediate rejection of allografts subjected to prolonged ischemia and this rejection is resistant to costimulatory blockade. These findings recapitulate the clinically significant impact of endogenous memory T cells with donor reactivity in a mouse transplant model in the absence of prior recipient priming.

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Early cardiac allograft failure after orthotopic heart transplantation

Cited by 35 publications

References 18 publications

Differential indication for mechanical circulatory support following heart transplantation

Differential indication for mechanical circulatory support following heart transplantation

Value of Cardiac Troponin I and T for Selection of Heart Donors and as Predictors of Early Graft Failure 1

Endogenous Memory CD8 T Cells Directly Mediate Cardiac Allograft Rejection

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