“Two in one”: Simultaneous functionalization and DOX loading for fabrication of nanodiamond-based pH responsive drug delivery system

Long, Wei; Ouyang, Hui; Wan, Weimin; Yan, Weigang; Zhou, Chaoqun; Huang, Hongye; Zhang, Xiaoyong; Feng, Yulin; Wei, Yen

doi:10.1016/j.msec.2019.110413

Cited by 24 publications

(19 citation statements)

References 66 publications

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“…And thus have lower responses to chemotherapeutics (i.e., cisplatin, vinblastine, paclitaxel) and ICIs. In accordance with those studies, the present study demonstrated that high-risk patients have signi cantly lower immune cell (e.g., CD8+ T cells) in ltration and immune function (e.g., immune checkpoint activation), possibly because immunotherapy-activated CD8+ T cells enhance lipid peroxidation and ferroptosis as a cytotoxic mechanism in CM cells and ultimately promote the e cacy of anti-CTLA-4 and anti-PD-1 therapies 108 .…”

Section: Aatbc (Apoptosis-associated Transcript In Bladder Cancer) Wa...supporting

confidence: 90%

Ferroptosis-Related lncRNA Signature Predicts Prognosis and Immunotherapy Efficacy in Cutaneous Melanoma

Niu

Yang

et al. 2022

Preprint

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Ferroptosis-related lncRNAs are promising biomarkers for predicting the prognosis of many cancers. However, a ferroptosis-related signature to predict the prognosis of cutaneous melanoma (CM) has not been identified. The purpose of our study was to construct a ferroptosis-related lncRNA signature to predict prognosis and immunotherapy efficacy in CM. Ferroptosis-related differentially expressed genes (FDEGs) and lncRNAs (FDELs) were identified using TCGA, GTEx, and FerrDb datasets. We performed Cox and LASSO regressions to identify key FDELs, and constructed a risk score to stratify patients into high- and low-risk groups. A nomogram was developed for clinical use. We performed gene set enrichment analyses (GSEA) to identify significantly enriched pathways. Differences in the tumor microenvironment (TME) between the 2 groups were assessed using 7 algorithms. To predict the efficacy of immune checkpoint inhibitors (ICI), we analyzed the association between PD1 and CTLA4 expression and the risk score. Finally, differences in Tumor Mutational Burden (TMB) and molecular drugs Sensitivity between the 2 groups were performed. Here, we identified 5 lncRNAs (AATBC, AC145423.2, LINC01871, AC125807.2, and AC245041.1) to construct the risk score. The AUC of the lncRNA signature was 0.743 in the training cohort and was validated in the testing and entire cohorts. Kaplan-Meier analyses revealed that the high-risk group had poorer prognosis. Multivariate Cox regression showed that the lncRNA signature was an independent predictor of OS with higher accuracy than traditional clinicopathological features. The 1-, 3-, and 5-year survival probabilities for CM patients were 92.7%, 57.2%, and 40.2% with an AUC of 0.804, indicating a good accuracy and reliability of the nomogram. GSEA showed that the high-risk group had lower ferroptosis and immune response. TME analyses confirmed that the high-risk group had lower immune cell infiltration (e.g., CD8+ T cells, CD4+ memory-activated T cells, and M1 macrophages) and lower immune functions (e.g., immune checkpoint activation). Low-risk patients whose disease expressed PD1 or CTLA4 were likely to respond better to ICIs. The analysis demonstrated that the TMB had significantly difference between low- and high- risk groups. Chemotherapy drugs, such as sorafenib, Imatinib, ABT.888 (Veliparib), Docetaxel, and Paclitaxel showed Significant differences in the estimated IC50 between the two risk groups. Overall, our novel ferroptosis-related lncRNA signature was able to accurately predict the prognosis and ICI outcomes of CM patients. These ferroptosis-related lncRNAs might be potential biomarkers and therapeutic targets for CM.

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Section: Aatbc (Apoptosis-associated Transcript In Bladder Cancer) Wa...supporting

confidence: 90%

Ferroptosis-Related lncRNA Signature Predicts Prognosis and Immunotherapy Efficacy in Cutaneous Melanoma

Niu

Yang

et al. 2022

Preprint

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“…It was a multicomponent NDs-based drug targeting system that inhibited the growth of HepG2 cells. The introduction of the ester group on the surface of NDs through thiol-ene reaction (Long et al, 2020) improved the water dispersibility and higher loading capacity. Through this reaction, DOX formed a link with CHO-PEG through hydrazine bonds.…”

Section: Nanodiamondsmentioning

confidence: 99%

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Debnath

Srivastava

2021

Front. Nanotechnol.

120

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With growing interest, a large number of researches have been conducted on carbon-based nanomaterials (CBNs). However, their uses are limited due to comprehensive potential environmental and human health effects. It is often confusing for researchers to make an informed choice regarding the versatile carbon-based nanocarrier system and its potential applications. This review has highlighted emerging applications and cutting-edge progress of CBNs in drug delivery. Some critical factors like enzymatic degradation, surface modification, biological interactions, and bio-corona have been discussed here. These factors will help to fabricate CBNs for effective drug delivery. This review also addresses recent advancements in carbon-based target specific and release controlled drug delivery to improve disease treatment. The scientific community has turned their research efforts into the development of novel production methods of CBNs to make their production more attractive to the industrial sector. Due to the nanosize and diversified physical properties, these CBNs have demonstrated distinct biological interaction. Thus long-term preclinical toxicity study is recommended before finally translating to clinical application.

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“…Fully synthesized polymers are used in the “grafted to” approach to modify the ND surface. Diverse functional groups (amine, thiol, hydroxyl, methacrylate, aldehyde, and NHS) terminated PEG molecules have been used [ 87 , 95 , 106 , 107 , 108 , 109 , 110 ]. A commonly employed scheme to attach PEG to the ND surface uses carboxylated NDs conjugated to amine functionalized PEG via a standard EDC coupling reaction [ 111 ].…”

Section: Covalent Functionalizationmentioning

confidence: 99%

Surface Modification of Fluorescent Nanodiamonds for Biological Applications

Jung

Neuman

2021

Nanomaterials

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Fluorescent nanodiamonds (FNDs) are a new class of carbon nanomaterials that offer great promise for biological applications such as cell labeling, imaging, and sensing due to their exceptional optical properties and biocompatibility. Implementation of these applications requires reliable and precise surface functionalization. Although diamonds are generally considered inert, they typically possess diverse surface groups that permit a range of different functionalization strategies. This review provides an overview of nanodiamond surface functionalization methods including homogeneous surface termination approaches (hydrogenation, halogenation, amination, oxidation, and reduction), in addition to covalent and non-covalent surface modification with different functional moieties. Furthermore, the subsequent coupling of biomolecules onto functionalized nanodiamonds is reviewed. Finally, biomedical applications of nanodiamonds are discussed in the context of functionalization.

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“Two in one”: Simultaneous functionalization and DOX loading for fabrication of nanodiamond-based pH responsive drug delivery system

Cited by 24 publications

References 66 publications

Ferroptosis-Related lncRNA Signature Predicts Prognosis and Immunotherapy Efficacy in Cutaneous Melanoma

Ferroptosis-Related lncRNA Signature Predicts Prognosis and Immunotherapy Efficacy in Cutaneous Melanoma

Drug Delivery With Carbon-Based Nanomaterials as Versatile Nanocarriers: Progress and Prospects

Surface Modification of Fluorescent Nanodiamonds for Biological Applications

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