Two highly sensitive fluorescent probes based on cinnamaldehyde with large Stokes shift for sensing of HSO3− in pure water and living cells

Pan, Xin; Cheng, Siyao; Zhang, Cheng; Qi, Xiao-Liang

doi:10.1007/s00216-020-02827-x

Cited by 32 publications

(14 citation statements)

References 35 publications

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“…In contrast to probe 39, the turn-on probe 40 was able to monitor bisulfite in real time (reaction completed within 30 s), and, the probe was imaged in vivo in live mice, and the results suggest that the probe can be used for the detection of bisulfite in serum of live mice. Meanwhile, in the study of Pan et al [74], probes 41a and 41b with the molecular structure as shown in the Scheme 8 were designed. Both probes have a large Stokes shift (250 nm), and it was shown that 41a containing carboxyl group responded more significantly to the fluorescence intensity change of HSO 3 − in pure water than 41b containing sulfoxide group, and 41a has lower cytotoxicity and better biocompatibility compared to 41b for the detection of HSO 3 − in living cells, in addition to better response characteristics.…”

Section: Ict Mechanismsmentioning

confidence: 99%

Small-Molecule Fluorescent Probe for Detection of Sulfite

Chen

Wang

et al. 2022

Pharmaceuticals

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Sulfite is widely used as an antioxidant additive and preservative in food and beverages. Abnormal levels of sulfite in the body is related to a variety of diseases. There are strict rules for sulfite intake. Therefore, to monitor the sulfite level in physiological and pathological events, there is in urgent need to develop a rapid, accurate, sensitive, and non−invasive approach, which can also be of great significance for the improvement of the corresponding clinical diagnosis. With the development of fluorescent probes, many advantages of fluorescent probes for sulfite detection, such as real time imaging, simple operation, economy, fast response, non−invasive, and so on, have been gradually highlighted. In this review, we enumerated almost all the sulfite fluorescent probes over nearly a decade and summarized their respective characteristics, in order to provide a unified platform for their standardized evaluation. Meanwhile, we tried to systematically review the research progress of sulfite small−molecule fluorescent probes. Logically, we focused on the structures, reaction mechanisms, and applications of sulfite fluorescent probes. We hope that this review will be helpful for the investigators who are interested in sulfite−associated biological procedures.

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Section: Ict Mechanismsmentioning

confidence: 99%

Small-Molecule Fluorescent Probe for Detection of Sulfite

Chen

Wang

et al. 2022

Pharmaceuticals

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“…Although the inorganic nanoparticle-based sensors show good detection performance, they commonly suffer from cytotoxicity related issues and thus have limited use for in vivo applications. 22−24 To overcome the shortcomings associated with inorganic nanoparticles, organic fluorescent probes, 25,26 demonstrated as contrast agents for bio-imaging applications due to low cytotoxicity and high enzyme resistance; 27−29 thus, their utilization as substrates for NA immobilization is expected to lead to sensors with enhanced biocompatibility. The polymer nanoparticles are also considered to have more design flexibility than the inorganic nanoparticles.…”

Section: ■ Introductionmentioning

confidence: 99%

“…To overcome the shortcomings associated with inorganic nanoparticles, organic fluorescent probes, , including dye-loaded polymer nanoparticles, present themselves as attractive alternatives. Dye-loaded polymer nanoparticles have been demonstrated as contrast agents for bio-imaging applications due to low cytotoxicity and high enzyme resistance; − thus, their utilization as substrates for NA immobilization is expected to lead to sensors with enhanced biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

DNA-Immobilized Fluorescent Polystyrene Nanoparticles as Probes with Tunable Detection Limits

Shin

2022

ACS Omega

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DNA-immobilized nanoparticle probes show high target specificity; thus, they are employed in various bioengineering and biomedicine applications. When the nanoparticles employed are dye-loaded polymer particles, the resulting probes have the additional benefit of biocompatibility and versatile surface properties. In this study, we construct DNA-immobilized fluorescent polystyrene (PS) nanoparticles through controlled surface reactions. PS nanoparticles with surface carboxyl groups are utilized, and amine-functionalized dye molecules and capture DNAs are covalently immobilized via a one-pot reaction. We show that the surface chemistry employed allows for quantitative control over the number of fluorescent dyes and DNA strands immobilized on the PS nanoparticle surfaces. The nanoparticles thus prepared are then used for DNA detection. The off state of the nanoprobe is achieved by hybridizing quencher-functionalized DNAs (Q-DNAs) to the capture DNAs immobilized on nanoparticle surfaces. Target-DNAs (T-DNAs) are detected by the displacement of the prehybridized Q-DNAs. The nanoprobes show successful detection of T-DNAs with high sequence specificity and long-term stability. They also show excellent detection sensitivity, and the detection limit can be tuned by adjusting the capture DNA-to-dye ratio.

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“…HSO 3 − is a reducing agent that plays the key role in industries such as dyes, papermaking, leather making, and chemical synthesis [10 − 13]. HSO 3 − can bleach cotton fabrics and organic substrate [14], treat chromium-containing waste water [15], and be used as an electroplating additive [16]. In the physiological system, HSO 3 − is mainly produced by the oxidation of cysteine and glutathione, and this process is mediated through reactive oxygen species (ROS) [17,18].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric and Ratiometric Fluorescence Detection of HSO3− With a NIR Fluorescent Dye

et al. 2021

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Bisul te (HSO 3 − ) has been widely used in food and industry, which has brought convenience to human life, but also seriously endangered human health. In this work, the probe PBI was designed and synthesized to detect bisul te (HSO 3 − ) through nucleophilic addition reaction. The probe PBI showed a selective reaction to HSO 3 − and can quantitatively detect HSO 3 − . At the same time, the color of the probe PBI changed signi cantly, which provided a simple method for the naked eye to identify HSO 3 − . Finally, it was successfully applied to the uorescence imaging of HSO 3 − in living cells.

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Two highly sensitive fluorescent probes based on cinnamaldehyde with large Stokes shift for sensing of HSO3− in pure water and living cells

Cited by 32 publications

References 35 publications

Small-Molecule Fluorescent Probe for Detection of Sulfite

Small-Molecule Fluorescent Probe for Detection of Sulfite

DNA-Immobilized Fluorescent Polystyrene Nanoparticles as Probes with Tunable Detection Limits

Colorimetric and Ratiometric Fluorescence Detection of HSO3− With a NIR Fluorescent Dye

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