Small-Molecule Fluorescent Probe for Detection of Sulfite

Abstract

Sulfite is widely used as an antioxidant additive and preservative in food and beverages. Abnormal levels of sulfite in the body is related to a variety of diseases. There are strict rules for sulfite intake. Therefore, to monitor the sulfite level in physiological and pathological events, there is in urgent need to develop a rapid, accurate, sensitive, and non−invasive approach, which can also be of great significance for the improvement of the corresponding clinical diagnosis. With the development of fluorescent probes, many advantages of fluorescent probes for sulfite detection, such as real time imaging, simple operation, economy, fast response, non−invasive, and so on, have been gradually highlighted. In this review, we enumerated almost all the sulfite fluorescent probes over nearly a decade and summarized their respective characteristics, in order to provide a unified platform for their standardized evaluation. Meanwhile, we tried to systematically review the research progress of sulfite small−molecule fluorescent probes. Logically, we focused on the structures, reaction mechanisms, and applications of sulfite fluorescent probes. We hope that this review will be helpful for the investigators who are interested in sulfite−associated biological procedures.

A bis-chalcone based colorimetric probe for the selective detection of bisulfite/sulfite anions: exploring surfactant promoted Michael addition of anions to α, β-unsaturated ketones

“…[19][20][21][22] Till now, several colorimetric and uorescent probes for the detection of the SO 2 derivatives (HSO 3 − /SO 3 2− ) have been designed and developed based on different sensing mechanisms such as the selective deprotection of levulinate group, [23][24][25] complexation with amines, 26,27 the selective reaction with aldehyde, 28,29 coordination to metal ions, 30 and Michael-type additions. 31,32 Among these different approaches 1,4-Michael addition of nucleophiles to a, b unsaturated systems that contain ester, ketone, nitrile, and nitro groups is one of the most versatile methods 33,34 for the development of chemosensors for the detection of SO 2 derivatives because this method allows the reaction to proceed under mild conditions. [35][36][37][38][39] Interestingly, Zhang et al (2013) 38 reported promising studies in this area, using a cationic cetyltrimethylammonium bromide (CTAB) micelle, to create a hydrophobic and basic microenvironment that promotes the addition reaction of sulte to an activated olen in aqueous solutions.…”

Kidney-Targeted Near-Infrared Fluorescence Probe Reveals That SO2 Is a Biomarker for Cisplatin-Induced Acute Kidney Injury

“…Therefore, the development of a sensitive fluorescence probe to study the relationship between SO 2 and drug-induced AKI is of great significance. Although many fluorescent probes have been reported to detect SO 2 in living systems, − no probe has been reported to detect SO 2 in drug-induced AKI.…”