Two grass carp (Ctenopharyngodon idella) insulin-like growth factor-binding protein 5 genes exhibit different yet conserved functions in development and growth

Zheng, Guo‐Dong; Zhou, Chun-Xue; Lin, Sitong; Chen, Jie; Jiang, Xia-Yun; Zou, Shu‐Ming

doi:10.1016/j.cbpb.2016.11.008

Cited by 12 publications

(14 citation statements)

References 48 publications

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“…This is in agreement with the anabolic function attributed to igfbp5, which has been identified as a good growth marker in gilthead sea bream 40 . Similar responses were detected in some species 41,42 ; but not in others 35,43,44 , although such a decrease is analogous to the Igfbp3 plasma levels determined in fasted coho and chinook salmon [45][46][47] , suggesting a similar response of these two igfbps to long term food deprivation in different fish species. Thus, Igfbps in teleost are differently affected by the various metabolic conditions 42 and in the case of gilthead sea bream muscle, igfbp5b seems to be the most sensitive form to food availability.…”

Section: Discussionsupporting

confidence: 74%

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Lavajoo

Perelló-Amorós

Vélez

et al. 2020

Sci Rep

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The tolerance of fish to fasting offers a model to study the regulatory mechanisms and changes produced when feeding is restored. Gilthead sea bream juveniles were exposed to a 21-days fasting period followed by 2 h to 7-days refeeding. Fasting provoked a decrease in body weight, somatic indexes, and muscle gene expression of members of the Gh/Igf system, signaling molecules (akt, tor and downstream effectors), proliferation marker pcna, myogenic regulatory factors, myostatin, and proteolytic molecules such as cathepsins or calpains, while most ubiquitin-proteasome system members increased or remained stable. In bone, downregulated expression of Gh/Igf members and osteogenic factors was observed, whereas expression of the osteoclastic marker ctsk was increased. Refeeding recovered the expression of Gh/Igf system, myogenic and osteogenic factors in a sequence similar to that of development. Akt and Tor phosphorylation raised at 2 and 5 h post-refeeding, much faster than its gene expression increased, which occurred at day 7. The expression in bone and muscle of the inhibitor myostatin (mstn2) showed an inverse profile suggesting an inter-organ coordination that needs to be further explored in fish. Overall, this study provides new information on the molecules involved in the musculoskeletal system remodeling during the early stages of refeeding in fish.conditions has been characterized and the ratio of the circulating levels of Gh and Igf1 is considered a good marker of growth quality in terms of its relation with body indexes or muscle fibers composition 12,13 .Muscle growth is also controlled by myogenic regulatory factors (MRFs) (MyoD, Myf5, Myog and Mrf4), and the negative endogenous regulator myostatin, as well as other factors that control sequentially the process of development and growth 6,14,15 . The effects of fasting and refeeding on myogenesis have been studied in diverse fish species 6,10,16 demonstrating the function of the different MRFs during the metabolic arrest caused with food limitation and the subsequent activation when feeding is restored. Furthermore, during fasting and refeeding, proteolytic molecules play a remarkable role to adapt to the changes in amino acids supply. This is more important in fish that have a specific and enhanced protein metabolism. The main endogenous proteolytic systems, each one performing specific degradative or regulatory functions according to the nutritional conditions are, calpains, cathepsins and ubiquitin-proteasome, all of which are well-known in fish, especially salmonids [17][18][19] , but also in gilthead sea bream [20][21][22] .In addition to muscle, bone is also an important tissue for skeletal and locomotion functions, but also, as a reservoir of minerals that is clearly affected when nutrition is restricted. Essential during development, synchronicity between bone and muscle is required for proper musculoskeletal growth 23,24 . Besides to being induced by the Gh/Igf system, the process of osteogenesis is also regulated by skeleton-derived factors that...

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Section: Discussionsupporting

confidence: 74%

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Lavajoo

Perelló-Amorós

Vélez

et al. 2020

Sci Rep

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“…In adult zebrafish, igfbp-5a was expressed at high levels in brain and gill, and lower levels in several other tissues, but was absent in liver or skeletal muscle; while igfbp-5b was ubiquitously expressed. Similarly, in other studied teleost species igfbp-5 genes were reported to show a broad tissue distribution, with differences noted among species and paralogs ( 51 , 52 , 55 , 63 , 120 ), including three paralogs in Atlantic salmon ( 16 , 24 ).…”

Section: Physiological Roles Of Teleost Igfbpsmentioning

confidence: 55%

“…In zebrafish and grass carp embryos, igfbp-5a and igfbp-5b have distinctive patterns of expression during early development, suggesting evolutionary divergence in regulation ( 19 , 120 ), which has also been demonstrated at the functional level ( 19 ). In adult zebrafish, igfbp-5a was expressed at high levels in brain and gill, and lower levels in several other tissues, but was absent in liver or skeletal muscle; while igfbp-5b was ubiquitously expressed.…”

Section: Physiological Roles Of Teleost Igfbpsmentioning

confidence: 88%

“…Similarly, igfbp-5a and igfbp-5b muscle expression did not change in response to short- or long-term fasting in Atlantic salmon ( 90 , 92 ). However, in grass carp, igfbp-5a and igfbp-5b expression decreased in skeletal muscle during fasting, while both paralogs were upregulated in liver, and upon injection of Gh in both tissues ( 120 ). In Gh transgenic coho salmon, igfbp-5b1 was significantly upregulated ( 103 ).…”

Section: Physiological Roles Of Teleost Igfbpsmentioning

confidence: 99%

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Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

serrana

Macqueen

2018

Front. Endocrinol.

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The insulin-like growth factor (Igf) binding protein (Igfbp) family has a broad range of physiological functions and a fascinating evolutionary history. This review focuses on the Igfbps of teleost fishes, where genome duplication events have diversified gene repertoire, function, and physiological regulation—with six core Igfbps expanded into a family of over twenty genes in some lineages. In addition to briefly summarizing the current state of knowledge on teleost Igfbp evolution, function, and expression-level regulation, we highlight gaps in our understanding and promising areas for future work.

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“…Igfbp5 is expressed in many tissues and has been linked to bone growth (Duan et al, 2005), juvenile development (Salih et al, 2004), and skeletal muscle differentiation (Ren et al, 2008;Safian et al, 2012). Transcripts encoding igfbp5a and igfbp5b are present in the liver of many teleost fishes (Breves et al, 2014;Gabillard et al, 2006;Kamangar et al, 2006;Safian et al, 2012;Pedroso et al, 2009;Zheng et al, 2017), but have generally not been shown to be sensitive to variation in nutritional status in this tissue (e.g., Breves et al, 2014;Gabillard et al, 2006). In skeletal muscle, however, Igfbp5 gene transcription does appear to be regulated by nutrition (Bower et al, 2008;Bower & Johnston, 2010;Gabillard et al, 2006;MacQueen et al, 2011;Zheng et al, 2017; but see Amaral & Johnston, 2011).…”

Section: Responses Of Igfbp and Igf1 Receptor Mrna Abundance To Ratiomentioning

confidence: 99%

The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)

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Two grass carp (Ctenopharyngodon idella) insulin-like growth factor-binding protein 5 genes exhibit different yet conserved functions in development and growth

Cited by 12 publications

References 48 publications

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

The Insulin-Like Growth Factor-1 (IGF1) System as a Potential Biomarker for Nutritional Status and Growth Rate in Pacific Rockfish (SEBASTES SPP.)

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