Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

serrana, Daniel García de la; Macqueen, Daniel J.

doi:10.3389/fendo.2018.00080

Cited by 71 publications

(51 citation statements)

References 145 publications

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“…Similar responses were detected in some species 41,42 ; but not in others 35,43,44 , although such a decrease is analogous to the Igfbp3 plasma levels determined in fasted coho and chinook salmon [45][46][47] , suggesting a similar response of these two igfbps to long term food deprivation in different fish species. Thus, Igfbps in teleost are differently affected by the various metabolic conditions 42 and in the case of gilthead sea bream muscle, igfbp5b seems to be the most sensitive form to food availability. Moreover, ghrs expression showed in this study a dual role, with the decrease of ghr1 until 5 h refeeding and a partial increase at 24 h and 7 days refeeding and the increase of ghr2 expression up to 24 h refeeding.…”

Section: Discussionsupporting

confidence: 74%

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Lavajoo

Perelló-Amorós

Vélez

et al. 2020

Sci Rep

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The tolerance of fish to fasting offers a model to study the regulatory mechanisms and changes produced when feeding is restored. Gilthead sea bream juveniles were exposed to a 21-days fasting period followed by 2 h to 7-days refeeding. Fasting provoked a decrease in body weight, somatic indexes, and muscle gene expression of members of the Gh/Igf system, signaling molecules (akt, tor and downstream effectors), proliferation marker pcna, myogenic regulatory factors, myostatin, and proteolytic molecules such as cathepsins or calpains, while most ubiquitin-proteasome system members increased or remained stable. In bone, downregulated expression of Gh/Igf members and osteogenic factors was observed, whereas expression of the osteoclastic marker ctsk was increased. Refeeding recovered the expression of Gh/Igf system, myogenic and osteogenic factors in a sequence similar to that of development. Akt and Tor phosphorylation raised at 2 and 5 h post-refeeding, much faster than its gene expression increased, which occurred at day 7. The expression in bone and muscle of the inhibitor myostatin (mstn2) showed an inverse profile suggesting an inter-organ coordination that needs to be further explored in fish. Overall, this study provides new information on the molecules involved in the musculoskeletal system remodeling during the early stages of refeeding in fish.conditions has been characterized and the ratio of the circulating levels of Gh and Igf1 is considered a good marker of growth quality in terms of its relation with body indexes or muscle fibers composition 12,13 .Muscle growth is also controlled by myogenic regulatory factors (MRFs) (MyoD, Myf5, Myog and Mrf4), and the negative endogenous regulator myostatin, as well as other factors that control sequentially the process of development and growth 6,14,15 . The effects of fasting and refeeding on myogenesis have been studied in diverse fish species 6,10,16 demonstrating the function of the different MRFs during the metabolic arrest caused with food limitation and the subsequent activation when feeding is restored. Furthermore, during fasting and refeeding, proteolytic molecules play a remarkable role to adapt to the changes in amino acids supply. This is more important in fish that have a specific and enhanced protein metabolism. The main endogenous proteolytic systems, each one performing specific degradative or regulatory functions according to the nutritional conditions are, calpains, cathepsins and ubiquitin-proteasome, all of which are well-known in fish, especially salmonids [17][18][19] , but also in gilthead sea bream [20][21][22] .In addition to muscle, bone is also an important tissue for skeletal and locomotion functions, but also, as a reservoir of minerals that is clearly affected when nutrition is restricted. Essential during development, synchronicity between bone and muscle is required for proper musculoskeletal growth 23,24 . Besides to being induced by the Gh/Igf system, the process of osteogenesis is also regulated by skeleton-derived factors that...

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Section: Discussionsupporting

confidence: 74%

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Lavajoo

Perelló-Amorós

Vélez

et al. 2020

Sci Rep

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“…); for some gene families, the retention rate of Ss4R gene duplicates is 100% (e.g. Garcia de la Serrana & Macqueen ). Additionally, one in five salmon genes belongs to a pair of more ancient gene duplicates retained from Ts3R, leading to highly expanded gene families compared to most non‐teleost vertebrates.…”

Section: Evolutionary History and Key Genetic Featuresmentioning

confidence: 99%

Atlantic salmon (Salmo salar L.) genetics in the 21st century: taking leaps forward in aquaculture and biological understanding

Houston

Macqueen

2018

Animal Genetics

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Summary Atlantic salmon ( Salmo salar L.) is among the most iconic and economically important fish species and was the first member of Salmonidae to have a high‐quality reference genome assembly published. Advances in genomics have become increasingly central to the genetic improvement of farmed Atlantic salmon as well as conservation of wild salmon stocks. The salmon genome has also been pivotal in shaping our understanding of the evolutionary and functional consequences arising from an ancestral whole‐genome duplication event characterising all Salmonidae members. Here, we provide a review of the current status of Atlantic salmon genetics and genomics, focussed on progress made from genome‐wide research aimed at improving aquaculture production and enhancing understanding of salmonid ecology, physiology and evolution. We present our views on the future direction of salmon genomics, including the role of emerging technologies (e.g. genome editing) in elucidating genetic features that underpin functional variation in traits of commercial and evolutionary importance.

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“…IGFBP-1 sub-types inhibit IGF signalling by sequestering IGFs in the extracellular environment and are major carriers of circulating IGF (Shimizu and Dickhoff, 2017). While their autocrine roles in teleost muscle are poorly understood, IGFBP-1A subtypes are thought to have evolved local functions, and are upregulated by catabolic signals in muscle (Garcia de la serrana and Macqueen, 2018). The upregulation of IGFBP-1A genes in WT fish to a level higher than TR and TF should therefore restrict IGF signalling and hence growth upon immune stimulation, whereas downregulation in GH transgenic fish should increase IGF availability to IGF1R.…”

Section: Gh Transgenesis Alters Gh and Igf System Expression Responsementioning

confidence: 99%

“…IGFBP-6B1 and -6B2 for Poly I:C in TR and TR). IGFBP-6 subtypes are considered negative regulators of growth (Garcia de la serrana and Macqueen, 2018) and are known to be induced by pro-inflammatory signals in Atlantic salmon muscle (Pooley et al, 2013). The reciprocal regulation of many IGFBPs during immune stimulation in TR and TF versus WT fish implies disruption in normal molecular cross-talk between growth and immunity owing to GH and its ability to impact growth rate and nutritional status.…”

Section: Gh Transgenesis Alters Gh and Igf System Expression Responsementioning

confidence: 99%

“…The IGF system comprises IGF-I and IGF-II hormones, which promote growth through IGF-1R signalling pathways (Jones and Clemmons, 1995;Wood et al, 2005), including in skeletal muscle (Johnston et al, 2011). The action of IGFs is modulated in the extracellular environment by a family of IGF-binding proteins (IGFBPs) that influence IGF availability to IGF-1R (Firth and Baxter, 2002; Garcia de la serrana and Macqueen, 2018). Genes from the GH and IGF pathways have been expanded by genome duplication events in teleost evolutionary history (Ocampo Daza et al, 2011;Macqueen et al, 2013;Lappin et al, 2016;Alzaid et al, 2016a;Robertson et al, 2017), including a salmonid-specific event that occurred 88-103 mya (Macqueen and Johnston, 2014).…”

Section: Introductionmentioning

confidence: 99%

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Growth hormone transgenesis in coho salmon disrupts muscle immune function impacting cross-talk with growth systems

Alzaid

Kim

Devlin

et al. 2018

Journal of Experimental Biology

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Suppression of growth during infection may aid resource allocation towards effective immune function. Past work supporting this hypothesis in salmonid fish revealed an immune-responsive regulation of the insulin-like growth factor (IGF) systeman endocrine pathway downstream of growth hormone (GH). Skeletal muscle is the main target for growth and energetic storage in fish, yet little is known about how its growth is regulated during an immune response. We addressed this knowledge gap by characterising muscle immune responses in size-matched coho salmon (Oncorhynchus kisutch) achieving different growth rates. We compared a wild-type strain with two GH transgenic groups from the same genetic background achieving either maximal or suppressed growtha design separating GH's direct effects from its influence on growth rate and nutritional state. Fish were sampled 30 h post-injection with phosphate-buffered saline (control) or mimics of bacterial or viral infection. We quantified mRNA expression levels for genes from the GH, GH receptor, IGF hormone, IGF1 receptor and IGF-binding protein families, along with immune genes involved in inflammatory or antiviral responses and muscle growth status marker genes. We demonstrate dampened immune function in GH transgenics compared with wild-type. The muscle of GH transgenics achieving rapid growth showed no detectable antiviral response, coupled with evidence of a constitutive inflammatory state. GH and IGF system gene expression was strongly altered by GH transgenesis and fast growth, both for baseline expression and responses to immune stimulation. Thus, GH transgenesis strongly disrupts muscle immune status and normal GH and IGF system expression responses to immune stimulation.

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Insulin-Like Growth Factor-Binding Proteins of Teleost Fishes

Cited by 71 publications

References 145 publications

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Regulatory mechanisms involved in muscle and bone remodeling during refeeding in gilthead sea bream

Atlantic salmon (Salmo salar L.) genetics in the 21st century: taking leaps forward in aquaculture and biological understanding

Growth hormone transgenesis in coho salmon disrupts muscle immune function impacting cross-talk with growth systems

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