Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus

Gao, Claire; Leng, Yan; Ma, Joongsoo; Rooke, Victoria; Rodriguez-Gonzalez, Shakira; Ramakrishnan, Charu; Deisseroth, Karl; Penzo, Mario

doi:10.1038/s41593-019-0572-3

Cited by 119 publications

(172 citation statements)

References 55 publications

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“…These findings suggest that the anterior part of the PVT controls motivated behaviors, which might be subserved partly by late CS + -selective neurons. However, it should be noted that this difference between the anterior and posterior parts of the PVT is rather quantitative in the present study since some late CS +selective neurons were also located in the posterior part of the PVT, consistent with a previous study showing that genetic and anatomical characteristics of the PVT gradually changed from its anterior to posterior parts (Gao et al, 2020).…”

Section: Response Characteristics Of the Cs + -Selective Pvt Neuronssupporting

confidence: 92%

Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Munkhzaya

Chinzorig

Matsumoto

et al. 2020

Front. Behav. Neurosci.

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Section: Response Characteristics Of the Cs + -Selective Pvt Neuronssupporting

confidence: 92%

Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Munkhzaya

Chinzorig

Matsumoto

et al. 2020

Front. Behav. Neurosci.

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“…These results are also consistent with a recent study showing that activity in mPFC neurons projecting to the PVT suppresses both the acquisition and expression of conditioned reward seeking (Otis et al, 2017). Based on recent evidence showing two genetically, anatomically and functionally distinct cell types across the anteroposterior axis of the PVT (Gao et al, 2020), it will be interesting to investigate in future studies whether the information from mPFC is transferred to anatomically or molecularly segregated cell types or projection-specific neurons within the PVT.…”

Section: Discussionmentioning

confidence: 99%

Punishment history biases corticothalamic responses to motivationally-significant stimuli

Lucantonio

Chang

et al. 2020

Preprint

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Making predictions about future rewards or pun-1 ishments is fundamental to adaptive behavior. 2 These processes are influenced by prior experi-3 ence. For example, prior exposure to aversive 4 stimuli or stressors changes behavioral responses 5 to negative-and positive-value predictive cues.6Here, we demonstrate a role for medial pre-7 frontal cortex (mPFC) neurons projecting to the 8 paraventricular nucleus of the thalamus (PVT; 9 mPFC→PVT) in this process. We found that a 10 history of punishments negatively biased behav-11 ioral responses to motivationally-relevant stim-12 uli in mice and that this negative bias was asso-13 ciated with hyperactivity in mPFC→PVT neu-14 rons during exposure to those cues. Further-15 more, artificially mimicking this hyperactive re-16 sponse with selective optogenetic excitation of 17 the same pathway recapitulated the punishment-18 induced negative behavioral bias. Together, our 19 results highlight how information flow within the 20 mPFC→PVT circuit is critical for making pre-21 dictions about imminent motivationally-relevant 22 outcomes as a function of prior experience. 23 vated by multiple forms of stressors (Chastrette et al., 75 1991; Sharp et al., 1991; Cullinan et al., 1995; Bubser 76 and Deutch, 1999; Spencer et al., 2004) and coordinate 77 behavioral responses to stress (Hsu et al., 2014; Do-78 Monte et al., 2015; Penzo et al., 2015; Zhu et al., 2016; 79 Do-Monte et al., 2017; Beas et al., 2018). On the other 80 hand, under conditions of opposing emotional valence, 81 PVT plays a role in multiple forms of stimulus-reward 82 learning and PVT neurons have been reported to show 83 reward-modulated responses (Schiltz et al., 2005; Igel-84 strom et al. , 2010; Martin-Fardon and Boutrel, 2012; 85 James and Dayas, 2013; Browning et al., 2014; Haight 86 and Flagel, 2014; Li et al., 2016; Choi et al., 2019). 87Activity in mPFC neurons projecting to the PVT also 88 suppresses both the acquisition and expression of condi-89 tioned reward seeking (Otis et al., 2017). 90Taken together, these studies place the mPFC to PVT 91 projection in a unique position to integrate information 92 about positive and negative motivationally-relevant cues 93 and translate it into adaptive behavioral responses. How 94 these projection-specific prefrontal neurons regulate be-95 115 phase, four odor cues (A, B, C and D, counterbalanced) 116 were presented. Odor A predicted an appetitive sweet 117 solution (3 µl of 5% sucrose water). Odor B predicted 118 an aversive bitter solution (3 µl of 10 mM denatonium 119 water). Odor C was associated with no reinforcement. 120 Odor D predicted a punishment (an unavoidable air puff 121 delivered to the mouse's right eye) in mice assigned to 122 the air puff group and was associated with no reinforce-123 ment in mice assigned to the no air puff group. Each 124 behavioral trial began with an odor (1 s; conditioned 125 stimulus, CS), followed by a 1-s delay and an outcome 126 (unconditioned stimulus, US). Mice showed essentially 127 binary respo...

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“…For example, neurons in aPVT are more likely to express dopamine D1 receptors, galanin, neurotensin, and neurotrophin receptor kinase 1 as compared with neurons in pPVT. In contrast, neurons in pPVT are more likely to express dopamine D2 receptors (Gao et al, 2020 ; Allen Brain Gene Search). Importantly, the transition from aPVT to pPVT is not obvious or sudden, as unique gene expression characteristics and projection dynamics among PVT neurons transition gradually along the anterior-posterior gradient rather than suddenly based on particular coordinates.…”

Section: Heterogeneous Cell Types In Pvtmentioning

confidence: 99%

Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors

McGinty

Otis

2020

Front. Behav. Neurosci.

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The paraventricular thalamic nucleus (PVT) is highly interconnected with brain areas that control reward-seeking behavior. Despite this known connectivity, broad manipulations of PVT often lead to mixed, and even opposing, behavioral effects, clouding our understanding of how PVT precisely contributes to reward processing. Although the function of PVT in influencing reward-seeking is poorly understood, recent studies show that forebrain and hypothalamic inputs to, and nucleus accumbens (NAc) and amygdalar outputs from, PVT are strongly implicated in PVT responses to conditioned and appetitive or aversive stimuli that determine whether an animal will approach or avoid specific rewards. These studies, which have used an array of chemogenetic, optogenetic, and calcium imaging technologies, have shown that activity in PVT input and output circuits is highly heterogeneous, with mixed activity patterns that contribute to behavior in highly distinct manners. Thus, it is important to perform experiments in precisely defined cell types to elucidate how the PVT network contributes to reward-seeking behaviors. In this review, we describe the complex heterogeneity within PVT circuitry that appears to influence the decision to seek or avoid a reward and point out gaps in our understanding that should be investigated in future studies.

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Two genetically, anatomically and functionally distinct cell types segregate across anteroposterior axis of paraventricular thalamus

Cited by 119 publications

References 55 publications

Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Punishment history biases corticothalamic responses to motivationally-significant stimuli

Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors

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