Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Munkhzaya, Unur; Chinzorig, Choijiljav; Matsumoto, Jumpei; Nishimaru, Hiroshi; Ono, Taketoshi; Nishijo, Hisao

doi:10.3389/fnbeh.2020.565002

Cited by 5 publications

(6 citation statements)

References 97 publications

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“…Optogenetic inhibition also demonstrated that PVT responses during the predictive cue and/or the reinforcing stimulus were necessary for reward seeking, aversive learning and extinction (Zhu et al, 2018). Another study also confirmed the involvement of PVT neurons in different aspects of cue-induced motivated behavior (Munkhzaya et al, 2020). Finally, PVT neurons also encode reward omission (Do-Monte et al, 2017;Zhu et al, 2018).…”

Section: Reward-seeking Behaviorsmentioning

confidence: 75%

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

Groote

d’Exaerde

2021

Front. Syst. Neurosci.

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The ventral striatum, also called nucleus accumbens (NAc), has long been known to integrate information from cortical, thalamic, midbrain and limbic nuclei to mediate goal-directed behaviors. Until recently thalamic afferents have been overlooked when studying the functions and connectivity of the NAc. However, findings from recent studies have shed light on the importance and roles of precise Thalamus to NAc connections in motivated behaviors and in addiction. In this review, we summarize studies using techniques such as chemo- and optogenetics, electrophysiology and in vivo calcium imaging to elucidate the complex functioning of the thalamo-NAc afferents, with a particular highlight on the projections from the Paraventricular Thalamus (PVT) to the NAc. We will focus on the recent advances in the understanding of the roles of these neuronal connections in motivated behaviors, with a special emphasis on their implications in addiction, from cue-reward association to the mechanisms driving relapse.

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Section: Reward-seeking Behaviorsmentioning

confidence: 75%

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

Groote

d’Exaerde

2021

Front. Syst. Neurosci.

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“…The PVT is also engaged in reward-seeking behaviors ( James et al, 2011a ; Browning et al, 2014 ; Choudhary et al, 2018 ). The PVT shows increased neuronal activation in response to reward and reward-associated cues ( Igelstrom et al, 2010 ; James et al, 2011a ; Yeoh et al, 2014 ; Munkhzaya et al, 2020 ). Suppression of PVT activities could attenuate reward-motivated behaviors ( Hamlin et al, 2009 ; Ong et al, 2017 ) (but see Stratford and Wirtshafter, 2013 ; Zhang and van den Pol, 2017 ).…”

Section: Connectivity Profiles Of Thalamic Nucleimentioning

confidence: 99%

The Contribution of Thalamic Nuclei in Salience Processing

Zhou

Zhu

Hou

et al. 2021

Front. Behav. Neurosci.

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The brain continuously receives diverse information about the external environment and changes in the homeostatic state. The attribution of salience determines which stimuli capture attention and, therefore, plays an essential role in regulating emotions and guiding behaviors. Although the thalamus is included in the salience network, the neural mechanism of how the thalamus contributes to salience processing remains elusive. In this mini-review, we will focus on recent advances in understanding the specific roles of distinct thalamic nuclei in salience processing. We will summarize the functional connections between thalamus nuclei and other key nodes in the salience network. We will highlight the convergence of neural circuits involved in reward and pain processing, arousal, and attention control in thalamic structures. We will discuss how thalamic activities represent salience information in associative learning and how thalamic neurons modulate adaptive behaviors. Lastly, we will review recent studies which investigate the contribution of thalamic dysfunction to aberrant salience processing in neuropsychiatric disorders, such as drug addiction, posttraumatic stress disorder (PTSD), and schizophrenia. Based on emerging evidence from both human and rodent research, we propose that the thalamus, different from previous studies that as an information relay, has a broader role in coordinating the cognitive process and regulating emotions.

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“…As in our previous studies (Uwano et al, 1995;Nishijo et al, 1998;Munkhzaya et al, 2020;Chinzorig et al, 2020), we used our head restraint system associated with a stereotaxic instrument (Nishijo and Norgren, 1990, 1991, 1997 (see Figure 1A). For this, briefly, the rats were anesthetized with an anesthetic mixture of midazolam (2 mg/kg, i.p.…”

Section: Surgerymentioning

confidence: 99%

Configural Cues Associated with Reward Elicit Theta Oscillations of Rat Retrosplenial Cortical Neurons Phase-Locked to LFP Theta Cycles

et al. 2021

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Previous behavioral studies implicated the retrosplenial cortex (RSC) in stimulus–stimulus associations, and also in the retrieval of remote associative memory based on EEG theta oscillations. However, neural mechanisms involved in the retrieval of stored information of such associations and memory in the RSC remain unclear. To investigate the neural mechanisms underlying these processes, RSC neurons and local field potentials (LFPs) were simultaneously recorded from well-trained rats performing a cue-reward association task. In the task, simultaneous presentation of two multimodal conditioned stimuli (configural CSs) predicted a reward outcome opposite to that associated with the individual presentation of each elemental CS. Here, we show neurophysiological evidence that the RSC is involved in stimulus–stimulus association where configural CSs are discriminated from each elementary CS that is a constituent of the configural CSs, and that memory retrieval of rewarding CSs is associated with theta oscillation of RSC neurons during CS presentation, which is phase-locked to LFP theta cycles. The results suggest that cue (elementary and configural CSs)-reinforcement associations are stored in the RSC neural circuits, and are retrieved in synchronization with LFP theta rhythm.

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Rat Paraventricular Neurons Encode Predictive and Incentive Information of Reward Cues

Cited by 5 publications

References 97 publications

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction

The Contribution of Thalamic Nuclei in Salience Processing

Configural Cues Associated with Reward Elicit Theta Oscillations of Rat Retrosplenial Cortical Neurons Phase-Locked to LFP Theta Cycles

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