Two-Generation Reproduction Study with para-tert-Octylphenol in Rats

Tyl, Rochelle W.; Myers, Christina; Marr, Melissa C.; Brine, Dolores R.; Fail, Patricia A.; Seely, J. Rodman; Miller, JP Van

doi:10.1006/rtph.1999.1343

Cited by 69 publications

(25 citation statements)

References 16 publications

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“…Many chemicals in surface waters and sediments have recently been discovered to have estrogenic/anti-estrogenic activity in vitro (Chapin et al, 1999;Delclos et al, 2001;Nagao et al, 2001;Ema et al, 2001;Tyl et al, 1999Tyl et al, , 2002. Among these compounds are natural and synthetic phytoestrogen and a variety of industrial chemicals (Colburn et al, 1996;Matthiesen et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

Seifert²,

et al. 2004

Environment International

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Section: Introductionmentioning

confidence: 99%

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

Seifert²,

et al. 2004

Environment International

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“…The NOAEL for toxic effects on postnatal development and maternal toxicity was 10.9 to 32.6 mg 4-tert-octylphenol/kg body weight and day (Tyl et al 1999). …”

Section: Discussionmentioning

confidence: 99%

“…In the 2-generation study, foetotoxicity was not observed up to postnatal day 13, but the time of vaginal opening or preputial separation was delayed at 111 to 369 mg/kg body weight and day. The NOAEL for toxic effects on postnatal development was thus 10.9 to 32.6 mg/kg body weight and day (Tyl et al 1999).…”

Section: Manifesto (Developmental Toxicity)mentioning

confidence: 99%

“…The body weight gains in the offspring were decreased at 111 to 369 mg/kg body weight and day on postnatal day 14 and thereafter. The NOAEL for toxic effects on postnatal development and maternal toxicity was 10.9 to 32.6 mg 4-tert-octylphenol/kg body weight and day (Tyl et al 1999). A 3-generation study in rats, which included the treatment of pups, examined only effects on the liver (Hernández-Rodríguez et al 2007).…”

Section: Screening and Generation Studiesmentioning

confidence: 99%

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4‐ tert ‐Octylphenol [MAK Value Documentation, 2017]

Hartwig¹,

Arand²

2018

The MAK‐Collection for Occupational Health and Safety

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The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated the developmental toxicity of 4‐tert‐octylphenol. In 2015, the maximum concentration at the workplace (MAK value) for 4‐tert‐octylphenol was set at 0.5 ml /m 3 (4.3 mg/m 3 ). In a screening study in rats with gavage administration, litter size and body weight of the progeny at postnatal day 4 was reduced at 500 mg/kg body weight and day, accompanied by maternal toxicity. A NOAEL for foetotoxicity of 250 mg/kg body weight and day was derived, corresponding to a concentration of 28.5 ml/m 3 at the workplace. In a 2‐generation feeding study in rats, foetotoxicity was not observed until postnatal day 13. At 111–369 mg/kg body weight and day, vaginal opening or preputial separation of the F2 progeny was delayed. A NOAEL of 10.9–32.6 mg/kg body weight and day was derived for postnatal developmental toxicity in rats, corresponding to 1.2–3.7 ml/m 3 . Because adequate studies of prenatal developmental toxicity over the complete period of organogenesis are lacking, data are not sufficient for classification and 4‐tert‐octylphenol is assigned to Pregnancy Risk Group D. Completed: October 7, 2015

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“…The no-observed-adverse-effect level was reported to be 10–50 mg/kg/day for NP [22] and 15–150 mg/kg/day for OP [23] in rats. Later, the uterotrophic studies revealed the lowest observed effect level of NP is 15 mg/kg/day [24].…”

Section: Discussionmentioning

confidence: 99%

Effects of <i>p</i>-Nonylphenol and 4-<i>tert</i>-Octylphenol on the Anterior Pituitary Functions in Adult Ovariectomized Rats

Furuta

Funabashi²,

Kawaguchi³

et al. 2006

Neuroendocrinology

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p-Nonylphenol (NP) and 4-tert-octylphenol (OP) are known to mimic the action of estrogens as endocrine disruptors. However, their acute effects on the pituitary and the hypothalamus functions in vivo have been uncertain. We therefore determined their effects on the anterior pituitary, in particular, gonadotropin secretion. Two weeks after ovariectomy, the rats were given a subcutaneous injection of 10 mg NP, 10 mg OP, 10 mg bisphenol A, 1 µg 17β-estradiol, or sesame oil alone as control. Twenty-four hours after the treatment, the expression of progesterone receptor mRNA in the anterior pituitary and the level of luteinizing hormone (LH), follicle-stimulating hormone, and prolactin were determined. The expression of progesterone receptor mRNA in the anterior pituitary was significantly increased by either NP, OP, bisphenol A, or estradiol, but bisphenol A was less effective. The level of LH was significantly decreased by either NP or OP, but not by bisphenol A and estradiol. Only estradiol significantly increased the level of prolactin. The level of follicle-stimulating hormone was unchanged by any of the treatments. To check the effects of NP and OP on pulsatile LH secretion, blood samplings were done at 6-min intervals for 3 h. Twenty-four hours after treatment in ovariectomized adult rats, we found that the injection of NP significantly decreased the amplitude of LH pulses and the mean LH concentrations, but not the frequency of LH pulses. The injection of OP significantly decreased the mean LH concentrations without affecting the frequency and amplitude of the LH pulses. Finally, the rats given an injection of NP or sesame oil were intravenously injected with 50 ng of gonadotropin-releasing hormone (GnRH) to check whether NP affected the LH secretory responsiveness of the anterior pituitary to GnRH. We found that the responsiveness to GnRH in NP-injected rats was significantly attenuated compared to the sesame oil-injected rats. The present study suggests that NP, even with a single injection, suppresses the pulsatile LH secretion in adult ovariectomized rats, probably by affecting the anterior pituitary level.

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Two-Generation Reproduction Study with para-tert-Octylphenol in Rats

Cited by 69 publications

References 16 publications

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

Comparative study of estrogenic potencies of estradiol, tamoxifen, bisphenol-A and resveratrol with two in vitro bioassays

4‐ tert ‐Octylphenol [MAK Value Documentation, 2017]

Effects of <i>p</i>-Nonylphenol and 4-<i>tert</i>-Octylphenol on the Anterior Pituitary Functions in Adult Ovariectomized Rats

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