Two Distinct Subtypes of Human Respiratory Syncytial Virus

Mufson, Maurice A.; Örvell, Claes; Rafnar, Björg; Norrby, Erling

doi:10.1099/0022-1317-66-10-2111

Cited by 583 publications

(482 citation statements)

References 44 publications

Supporting

Mentioning

445

Contrasting

Unclassified

Order By: Relevance

“…A parallel situation to PDV and CDV appears to exist with human respiratory syncytial (RS) virus, of the pneumovirus genus of paramyxoviruses, which has been divided into subgroups A and B. The large glycoprotein (named G in RS virus) differs immunologically between the two subgroups, whereas the other proteins of the virus show a close immunological relationship between subgroups (Mufson et al, 1985;Anderson et aL, 1985;Orvell et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Örvell

Blixenkrone-Møller²,

Svansson³

et al. 1990

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Örvell

Blixenkrone-Møller²,

Svansson³

et al. 1990

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

“…The virus exhibits considerable genetic variability, primarily in the attachment (G) glycoprotein [2]. This variability is reflected antigenically, and hRSV can be divided into two groups (A and B) on the basis of reactions with panels of monoclonal antibodies [3,4]. Children usually experience their first infection before the age of 2 years, and reinfection is a common occurrence in older children and also in adults [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection

et al. 2005

View full text Add to dashboard Cite

SUMMARYHuman respiratory syncytial virus (hRSV) transmission dynamics are inherently cyclical, and the observed genetic diversity (between groups A and B) also appears to have a repeating pattern. A key unknown is the extent to which genetic variants interact immunologically, and thus impact on epidemiology. We developed a novel mathematical model for hRSV transmission including seasonal forcing of incidence and temporary intra-and inter-group partial immunity. Simultaneous model fits to data from two locations (England & Wales, UK, and Turku, Finland) successfully reproduced the contrasting infection dynamics and group A/B dominance patterns. Parameter estimates are consistent with direct estimates. Differences in the magnitude and seasonal variation in contact rate between the two populations alone could account for the variation in dynamics between these populations. The A/B group dominance patterns are explained by reductions in susceptibility to and infectiousness of secondary homologous and heterologous infections. The consequences of the observed dynamic complexity are discussed.

show abstract

“…RSV is classified within the family Paramyxoviridae, genus Pneumovirus, and is divided into two antigenic subgroups, A and B [Anderson et al, 1985;Mufson et al, 1985;Tsutsumi et al, 1988]. These subgroups are divided into several different genotypes [Peret et al, 1998[Peret et al, , 2000.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology and genetic variability of respiratory syncytial virus (RSV) in Stockholm, 2002–2003

Östlund¹,

Lindell²,

Stenler³

et al. 2007

Journal of Medical Virology

View full text Add to dashboard Cite

The epidemiology and genetic variability of circulating respiratory syncytial virus (RSV) strains in Stockholm during the season 2002-2003 were studied in consecutive RSV isolates derived from respiratory samples and diagnosed in the laboratory. Two hundred thirty-four viruses were sequenced. The samples were mainly from children under 1 year old (79%). The phylogeny of the N-terminal part of the G gene was studied after amplification and sequencing. One hundred fifty-two viruses belonged to subgroup B and 82 to subgroup A. The subgroup A viruses could be further divided into genotypes GA2 (25) and GA5 (57) and the subgroup B viruses into GB3 (137) and SAB1 (15) strains. These strains clustered with subgroup A and subgroup B strains from Kenya from the same period, as well as with strains from Great Britain from 1995 to 1998. The dominance of subgroup B strains in Stockholm during 2002-2003 is in agreement with findings from other parts of the world during the same years. Only two genotypes of subgroup A, GA2 and GA5, were circulating during this time, and GA2 has been circulating in Sweden for more than 20 years. Consecutive strains from the same individual displayed no variability in the sequenced region, which was also true of strains that had been passaged in cell cultures.

show abstract

Two Distinct Subtypes of Human Respiratory Syncytial Virus

Cited by 583 publications

References 44 publications

Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

The transmission dynamics of groups A and B human respiratory syncytial virus (hRSV) in England & Wales and Finland: seasonality and cross-protection

Molecular epidemiology and genetic variability of respiratory syncytial virus (RSV) in Stockholm, 2002–2003

Contact Info

Product

Resources

About