Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Örvell, Claes; Blixenkrone-Møller, Merete; Svansson, Vilhjálmur; Have, P.

doi:10.1099/0022-1317-71-9-2085

Cited by 59 publications

(41 citation statements)

References 22 publications

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“…The H gene protein is responsible for viral attachment to the cell host (38) and may also play a role in induction of protective immunity (11). The H protein is one of the most variable morbillivirus proteins and thus has often been used to assess genetic changes between CDV isolates (8,9,17,18,20,21,23,26,28,30).In this study, postmortem findings, immunohistochemical labeling, and reverse transcription (RT)-PCR specific for CDV genomic RNA established a definitive diagnosis of disease caused by CDV infection in four naturally occurring canine cases in Missouri that occurred between June and October 2004. Approximately 4.5 kb of genomic nucleotide sequence was determined for each of these four cases.…”

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Phylogenetic Characterization of Canine Distemper Viruses Detected in Naturally Infected Dogs in North America

2005

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In 2004, six puppies and one adult dog from a total of four premises were subjected to necropsy evaluation. For five of the seven dogs, disease caused by canine distemper virus (CDV) infection was suspected based on clinical signs. In all of the dogs, a diagnosis of CDV infection was established by the presence of compatible gross and histologic lesions, immunohistochemical labeling for CDV antigen, and detection of CDV RNA by reverse transcription-PCR. To further characterize the CDV strains detected in the four cases, complete gene sequences were determined for the hemagglutinin (H) and fusion (F) protein genes, while partial gene sequencing was performed for the phosphoprotein gene. A total of 4,508 bases were sequenced for the CDV strains detected from each of the four cases. Two cases were found to have identical sequences except for 2 bases in the intergenic region of the F and H genes. Phylogenetic analysis strongly suggested an evolutionary relationship between sequences detected in these two cases and those of phocine distemper virus 2 and two other strains of CDV not previously detected in the continental United States. Clear phylogenetic relationships were not established for viruses detected in the two additional cases; however, one strain showed similarity to CDV strains detected in a panda from China. Importantly, the three CDV strains detected were demonstrated to be genetically distinct from known vaccine strains and strains previously reported in the continental United States.Canine distemper virus (CDV) is the etiological agent of one the most important viral diseases of wild and domestic Canidae (dog, dingo, fox, coyote, jackal, and wolf) (2). It occurs worldwide and produces high morbidity and mortality in immunologically naïve populations (22,29). This virus also infects a broad range of other animals, such as Mustelidae (ferrets, minks, skunks, weasels, and badgers), Procyonidae (raccoons and pandas), Ursidae (bears), Viverridae (civets, genets, and linsangs), hyaenidae (hyenas), and Felidae (lions and tigers) (2,3,4,10,12,16,36). Canine distemper virus is classified in the genus Morbillivirus within the family Paramyxoviridae and has an unsegmented, negative-sense, single-stranded, ϳ15.7-kb RNA genome and an enveloped virus particle that is 150 to 300 nm in diameter (29). The pathogenesis of CDV infection in dogs has been well characterized (2,22,29,35). The genome of CDV encodes the following virion proteins: matrix (M), fusion (F), hemagglutinin (H), nucleocapsid (N), polymerase (L), and phosphoprotein (P). The H gene protein is responsible for viral attachment to the cell host (38) and may also play a role in induction of protective immunity (11). The H protein is one of the most variable morbillivirus proteins and thus has often been used to assess genetic changes between CDV isolates (8,9,17,18,20,21,23,26,28,30).In this study, postmortem findings, immunohistochemical labeling, and reverse transcription (RT)-PCR specific for CDV genomic RNA established a definitive diagnosis of diseas...

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Phylogenetic Characterization of Canine Distemper Viruses Detected in Naturally Infected Dogs in North America

2005

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“…A panel of MAbs raised against the NP (n = 3), H (n = 11) and F (n = 5) proteins of PDV-1 (Orvell et al, 1990) was used to define antigenic cross-reactivities between PDV-1, DMV, PMV and CDV in the indirect ELISA (Table 1). Of these MAbs, two H-specific and all the F-specific MAbs cross-reacted with CDV and three of the F-specific MAbs cross-reacted with DMV and PMV.…”

Section: Antigenic Cross-reactivities Between Dmv Pmv and Other Morbmentioning

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Characterization of morbilliviruses isolated from dolphins and porpoises in Europe

Visser

Bressem

Swart

et al. 1993

Journal of General Virology

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“…It still remains a possibility that PDV, with a reduced virulence for terrestrial mammals, is circulating in these species and causes mass die-offs in pinnipeds after crossing the species barrier [4]. Before 1988, cross-species infection between minks and seals had been reported [4,24], but little is known about the role of terrestrial carnivores such as minks and polar bears during the second PDV outbreak. Virus-infected minks from coastal areas around the North Sea, as well as Canadian Arctic polar bears preying on arctic seals could be a potential source of infection or transmission of PDV to seals.…”

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In search of virus carriers of the 1988 and 2002 phocine distemper virus outbreaks in European harbour seals

Kreutzer

Siebert³

et al. 2007

Arch Virol

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Immunological relationships between phocid and canine distemper virus studied with monoclonal antibodies

Cited by 59 publications

References 22 publications

Phylogenetic Characterization of Canine Distemper Viruses Detected in Naturally Infected Dogs in North America

Phylogenetic Characterization of Canine Distemper Viruses Detected in Naturally Infected Dogs in North America

Characterization of morbilliviruses isolated from dolphins and porpoises in Europe

In search of virus carriers of the 1988 and 2002 phocine distemper virus outbreaks in European harbour seals

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