Two distinct neural networks functionally connected to the human hippocampus during pattern separation tasks

Paleja, Meera; Girard, Todd A.; Herdman, Katherine A.; Christensen, Bruce K.

doi:10.1016/j.bandc.2014.10.009

Cited by 25 publications

(21 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, co-activation between the cerebellum and hippocampus occurs during a version of the task with a spatio-temporal prediction component, but not during similar tasks when prediction is not required. Similarly, as briefly mentioned earlier, the cerebellum and hippocampus were found to be part of a domain-general pattern separation network, active in both spatial and temporal variations of a delayed match-to-sample task (Paleja et al, 2014 ).…”

Section: Cerebellar-hippocampal Interactions In Temporal Processingmentioning

confidence: 56%

“…Notably, recent studies have reported important functional interactions between the cerebellum and the hippocampal formation (Rochefort et al, 2011 ; Krook-Magnuson et al, 2014 ; Onuki et al, 2015 ). For instance, while the process of pattern separation has been studied primarily within subregions of the hippocampal formation, it was recently reported that the cerebellum is also actively engaged during pattern separation tasks (Paleja et al, 2014 ). Conversely, tasks known to be heavily cerebellum-dependent can be significantly influenced by the hippocampus (Hoffmann and Berry, 2009 ; Wikgren et al, 2010 ; Hoffmann et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Krook-Magnuson

2015

Front. Syst. Neurosci.

102

View full text Add to dashboard Cite

There is a growing recognition that the utility of the cerebellum is not limited to motor control. This review focuses on the particularly novel area of hippocampal-cerebellar interactions. Recent work has illustrated that the hippocampus and cerebellum are functionally connected in a bidirectional manner such that the cerebellum can influence hippocampal activity and vice versa. This functional connectivity has important implications for physiology, including spatial navigation and timing-dependent tasks, as well as pathophysiology, including seizures. Moving forward, an improved understanding of the critical biological underpinnings of these cognitive collaborations may improve interventions for neurological disorders such as epilepsy.

show abstract

Section: Cerebellar-hippocampal Interactions In Temporal Processingmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Krook-Magnuson

2015

Front. Syst. Neurosci.

102

View full text Add to dashboard Cite

show abstract

“…Although there are some differences in the subfield distributions along the long axis of the human hippocampus (Malykhin, Lebel, Coupland, Wilman, & Carter, ), most studies looked at the entire subfield so it was not possible to localize activity to anterior or posterior segments. Of the few studies that have reported anterior versus posterior hippocampal activation, those assessing pattern separation have reported both anterior (Berron et al, ; Loh et al, ; Milivojevic, Vicente‐Grabovetsky, & Doeller, ; Paleja, Girard, Herdman, & Christensen, ) and posterior hippocampal activation (Motley & Kirwan, ; Schlichting et al, ), whereas two studies looking at pattern completion have reported anterior hippocampal activation (Horner, Bisby, Bush, Lin, & Burgess, ; Schlichting et al, ).…”

Section: Resultsmentioning

confidence: 99%

Meta‐analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis

Grady

2019

Hippocampus

View full text Add to dashboard Cite

There is considerable evidence from non-human animal studies that the anterior and posterior regions of the hippocampus have different anatomical connections and support different behavioural functions. Although there are some recent human studies using functional magnetic resonance imaging (fMRI) that have addressed this idea directly in the memory and spatial processing domains and provided support for it, there has been no broader meta-analysis of the fMRI literature to determine if there is consistent evidence for functional dissociations in anterior and posterior hippocampus across all of the different cognitive domains in which the hippocampus participates. The purpose of this review is to address this gap in our knowledge using three approaches. One approach involved PubMed searches to identify relevant fMRI papers reporting hippocampal activation during episodic encoding and retrieval, semantic retrieval, working memory, spatial navigation, simulation/scene construction, transitive inference, and social cognition tasks. The second was to use a large meta-analytic database (neurosynth) to find text terms and coactivation maps associated with the anterior and posterior hippocampal regions identified in the literature search. The third approach was to contrast the resting-state functional connectivity of the anterior and posterior hippocampal regions using a publicly available database that includes a large sample of adults. These three approaches provided converging evidence that not only are cognitive processes differently distributed along the hippocampal axis, but there also are distinct areas coactivated and functionally connected with the anterior and posterior segments. This anterior/posterior distinction involving multiple cognitive domains is consistent with the animal literature and provides strong support from fMRI for the idea of functional dissociations across the long axis of the hippocampus. K E Y

show abstract

“…Previous studies have observed similar engagement of occipital cortex during MD using continuous recognition paradigms and repetition-sensitive analysis approaches (Motley & Kirwan, 2012;Pidgeon & Morcom, 2016). Functional connectivity between the hippocampus and early visual regions during MD (Paleja, Girard, Herdman, & Christensen, 2014) further suggests that cortico-hippocampal interactions support discrimination performance. However, rather than playing a direct role in MD, theoretical accounts propose that occipital cortex contributes to memory recollection by providing a visual representation for the hippocampus to pattern separate (Rolls, 2017).…”

Section: Discussionmentioning

confidence: 99%

Neural substrates of mnemonic discrimination: A whole‐brain fMRI investigation

2020

View full text Add to dashboard Cite

Introduction A fundamental component of episodic memory is the ability to differentiate new and highly similar events from previously encountered events. Numerous functional magnetic resonance imaging (fMRI) studies have identified hippocampal involvement in this type of mnemonic discrimination (MD), but few studies have assessed MD‐related activity in regions beyond the hippocampus. Therefore, the current fMRI study examined whole‐brain activity in healthy young adults during successful discrimination of the test phase of the Mnemonic Similarity Task. Method In the study phase, participants made “indoor”/“outdoor” judgments to a series of objects. In the test phase, they made “old”/“new” judgments to a series of probe objects that were either repetitions from the memory set (targets), similar to objects in the memory set (lures), or novel. We assessed hippocampal and whole‐brain activity consistent with MD using a step function to identify where activity to targets differed from activity to lures with varying degrees of similarity to targets (high, low), responding to them as if they were novel. Results Results revealed that the hippocampus and occipital cortex exhibited differential activity to repeated stimuli relative to even highly similar stimuli, but only hippocampal activity predicted discrimination performance. Conclusions These findings are consistent with the notion that successful MD is supported by the hippocampus, with auxiliary processes supported by cortex (e.g., perceptual discrimination).

show abstract

Two distinct neural networks functionally connected to the human hippocampus during pattern separation tasks

Cited by 25 publications

References 65 publications

Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Meta‐analytic and functional connectivity evidence from functional magnetic resonance imaging for an anterior to posterior gradient of function along the hippocampal axis

Neural substrates of mnemonic discrimination: A whole‐brain fMRI investigation

Contact Info

Product

Resources

About