Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Yu, Wilson; Krook-Magnuson, Esther

doi:10.3389/fnsys.2015.00177

Cited by 99 publications

(81 citation statements)

References 159 publications

(171 reference statements)

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“…Related to this, to what extent a connection between the cerebellum and hippocampus in this context is direct (Arrigo et al, ), or indirect (Yu & Krook‐magnuson, ) cannot be specifically inferred from our data. It is possible that the parietal cortex plays an important role, given that both ERP and fMRI data indicated that this region is significantly more active during perceiving changes that arise from novel viewpoints.…”

Section: Discussionmentioning

confidence: 67%

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Hauser

Heba

Schmidt‐Wilcke

et al. 2019

Human Brain Mapping

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In addition to its role in visuospatial navigation and the generation of spatial representations, in recent years, the hippocampus has been proposed to support perceptual processes. This is especially the case where high‐resolution details, in the form of fine‐grained relationships between features such as angles between components of a visual scene, are involved. An unresolved question is how, in the visual domain, perspective‐changes are differentiated from allocentric changes to these perceived feature relationships, both of which may be argued to involve the hippocampus. We conducted functional magnetic resonance imaging of the brain response (corroborated through separate event‐related potential source‐localization) in a passive visuospatial oddball‐paradigm to examine to what extent the hippocampus and other brain regions process changes in perspective, or configuration of abstract, three‐dimensional structures. We observed activation of the left superior parietal cortex during perspective shifts, and right anterior hippocampus in configuration‐changes. Strikingly, we also found the cerebellum to differentiate between the two, in a way that appeared tightly coupled to hippocampal processing. These results point toward a relationship between the cerebellum and the hippocampus that occurs during perception of changes in visuospatial information that has previously only been reported with regard to visuospatial navigation.

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Section: Discussionmentioning

confidence: 67%

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Hauser

Heba

Schmidt‐Wilcke

et al. 2019

Human Brain Mapping

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“…Evidence for a cerebellar involvement in working memory comes from functional imaging studies of verbal or visual working memory in humans, showing localized activation of right cerebellar lobulus simplex (LS) and Crus I 1 . Animal studies have shown that normal place cell function in the hippocampus as well as spatial orientation behavior requires an intact cerebellum [2][3][4][5][6] . Neural tracing studies in mice revealed connections between the posterior cerebellar hemisphere and the hippocampus 5 .…”

Section: Discussionmentioning

confidence: 99%

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Liu

McAfee

Heijden

et al. 2020

Preprint

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Spatial working memory (SWM) in rodents jointly requires the medial prefrontal cortex (mPFC) and dorsal hippocampal CA1 region (dCA1). We show that the decision-making process in a SWM task is associated with increased coherence of gamma oscillations between the mPFC and dCA1, with the magnitude of coherence change correlated with decision outcome. Purkinje cells in the cerebellar lobulus simplex (LS) have been shown to represent mPFC and dCA1 gamma oscillation phase and phase differences. Here we show that the LS is causally involved in the modulation of decision-related mPFC-dCA1 gamma coherence and SWM performance. Previous studies reported a cerebellar involvement in modulating coherence between sensory and motor cortical areas. Together these findings suggest cerebellar modulation of cerebral cortical coherence as a possible universal mechanism of cerebrocerebellar interaction.

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“…To the best of our knowledge, no structure has been identified that represents mPFC-CA1 phase differences and projects to the cerebellum. Thus, based on current knowledge and because the cerebellum has reciprocal connections with both the mPFC 3,56,57 and the hippocampus 58-60, we consider the latter scenario more likely. This then calls for an explanation for how the cerebellar network extracts phase difference information from mossy fiber input, assuming that the mossy fiber activity carries phase-information about oscillations in each structure.…”

Section: Discussionmentioning

confidence: 99%

Cerebellar Purkinje cell simple spike activity in awake mice represents phase differences between oscillations in medial prefrontal cortex and hippocampus

McAfee

Liu

Sillitoe

et al. 2017

Preprint

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Abstract:The cerebellum has long been recognized for its role in tasks involving precise timing, particularly the temporal coordination of movements. Here we asked whether cerebellar might be involved in the temporal coordination of the phases of neuronal oscillations in the medial prefrontal cortex (mPFC) and dorsal hippocampus CA1 region (CA1). These two structures and the cerebellum are jointly involved in spatial working memory. The phases of oscillations in the mPFC and CA1 have been shown to reach a stable alignment (coherence) during the decision making process in a spatial working memory task. Here we report that PC simple spike activity in the cerebellar lobulus simplex in awake, head-fixed mice represents specific phase differences between oscillations in the mPFC and CA1. Most PCs represented phase differences in more than one the conventional frequency bands (delta, theta, beta and gamma). Between the 32 PCs analyzed here, phase differences in all frequency bands were represented. PCs representing phase differences in the theta and low gamma bands showed significant population preference for mPFC phase leading CA1 phase. These findings support the possibility of a cerebellar involvement in the temporal coordination of phase relationships between oscillations in the mPFC and CA1.Introduction:

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Cognitive Collaborations: Bidirectional Functional Connectivity Between the Cerebellum and the Hippocampus

Cited by 99 publications

References 159 publications

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Causal evidence for a cerebellar role in prefrontal-hippocampal interaction in spatial working memory decision-making

Cerebellar Purkinje cell simple spike activity in awake mice represents phase differences between oscillations in medial prefrontal cortex and hippocampus

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