Two distinct groups of immunoglobulin A(IgA) revealed by peptic digestion

Wilson, I. Dodd; Williams, Ralph C.

doi:10.1172/jci106207

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Biologicd Significance Of Salivary Immunoglobulin Components1

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1970

1983

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Cited by 31 publications

(1 citation statement)

References 23 publications

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“…Shim et al (1969) observed that colostral IgA exhibited a self-protecting activity against tryptic digestion, which they ascribed to the bound SP. Wilson & Williams (1969), on the other hand, found that SP conferred at most a minor resistance to peptic digestion; and Keller & Dwyer (1968) observed degradation of IgA in stools from adults.…”

Section: Biologicd Significance Of Salivary Immunoglobulin Componentsmentioning

confidence: 99%

Human Secretory Immunoglobulins

Brandtzæg

Fjellanger

Gjeruldsen

1970

Scandinavian Journal of Haematology

157

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Section: Biologicd Significance Of Salivary Immunoglobulin Componentsmentioning

confidence: 99%

Human Secretory Immunoglobulins

Brandtzæg

Fjellanger

Gjeruldsen

1970

Scandinavian Journal of Haematology

157

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Immunoglobulin Synthesis and Transport by Human Salivary Glands

Hürlimann¹

1971

Current Topics in Pathology / Ergebnisse Der Pathologie

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Pathogenic role of a monoclonal IgA (?) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritis

1982

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Sixteen years earlier a 42-year-old woman with an IgA kappa plasma cell neoplasm presented with bleeding disorder. Her prolonged course was complicated by subsequent development of rheumatoid arthritis, vascular purpura, and an acute membranoproliferative glomerulonephritis (MPGN). The paraprotein and its (Fab')2 fragment showed affinity for a test myeloma IgG2 (lambda ) paraprotein. The patient's serum and the IgA-IgG complex separated by gel filtration did not exhibit cryoprecipitation. The complex also did not dissociate by ultracentrifugation. Electron microscopic and immunofluorescent studies of a renal biopsy sample taken during the episode of nephritis showed subendothelial deposits and a lacy fluorescent pattern strongly positive for IgA and IgG. The same immunoglobulins were eluted from the kidney at postmortem. A low concentration of monoclonal IgA kappa (antibody) and excess unbound polyclonal IgG (antigen) were demonstrated in the patient's serum at the time of MPGN, apparently analogous to the conditions necessary for the induction of experimental immune complex nephritis.

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Two distinct groups of immunoglobulin A(IgA) revealed by peptic digestion

Cited by 31 publications

References 23 publications

Human Secretory Immunoglobulins

Human Secretory Immunoglobulins

Immunoglobulin Synthesis and Transport by Human Salivary Glands

Pathogenic role of a monoclonal IgA (?) anti-IgG paraprotein associated with hemorrhagic diathesis, rheumatoid arthritis, vascular purpura, and acute membranoproliferative glomerulonephritis

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