Two distinct classes of carbohydrate-recognition domains in animal lectins.

Drickamer, Kurt

doi:10.1016/s0021-9258(19)81549-1

Cited by 1,162 publications

(160 citation statements)

References 57 publications

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“…Similarly, some of the key proteins that distinguish the glue from lubricating mucous secretions appear to be C-lectins [11]. C-lectins use calcium ion binding domains to bind to other proteins or carbohydrates [14].…”

Section: Introductionmentioning

confidence: 99%

Elasticity and energy dissipation in the double network hydrogel adhesive of the slug Arion subfuscus

Fung

Lazo

Smith

2019

Phil. Trans. R. Soc. B

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The slug Arion subfuscus produces a mucus-based defensive secretion that is remarkably tough. This glue appears to be a double network hydrogel, gaining its toughness through the synergistic actions of two networks of polymers, a relatively stiff network and a relatively deformable network. The double network mechanism has great potential to guide the development of synthetic adhesives. Mechanical tests were performed to analyse key predictions of the mechanism. Stress relaxation tests and tensile tests support the presence of stable cross-links. Cyclic stress–strain tests demonstrate that the glue dissipates a great deal of energy through the failure of these cross-links as sacrificial bonds. Energy dissipation by failure of sacrificial bonds rather than viscous processes is supported by the minimal effect of the time course of the experiments on the measured properties. These sacrificial bonds appear able to reform within minutes after failure. Finally, the glue's stiffness decreases at pH values below 5.5, whereas magnesium and calcium rapidly dissociate from the glue at all pH values tested. Thus, these ions may not be the primary cross-linkers generating the glue's stiffness. This article is part of the theme issue ‘Transdisciplinary approaches to the study of adhesion and adhesives in biological systems’.

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Section: Introductionmentioning

confidence: 99%

Elasticity and energy dissipation in the double network hydrogel adhesive of the slug Arion subfuscus

Fung

Lazo

Smith

2019

Phil. Trans. R. Soc. B

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“…C ollectins are a family of proteins that contain two characteristic structures, a collagen-like region and a carbohydrate recognition domain (CRD) (Drickamer 1988). There are three classical collectins in humans: mannan-binding lectin (MBL) (Kawasaki et al 1983; Sastry et al 1991; Laursen et al 1998; Laursen and Nielsen 2000) and surfactant proteins A and D (SP-A and SP-D) (Benson et al 1985; Haagsman et al 1987; Andersen et al 1992).…”

mentioning

confidence: 99%

Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues

Motomura

Yoshizaki

Ohtani

et al. 2007

J Histochem Cytochem.

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We have recently identified a novel collectin, CL-K1, that may play a role in innate immunity as a member of the collectin family. In this study using mice, we investigated the tissue distribution of CL-K1 for better understanding of its pathophysiological relevance. Real-time PCR analyses demonstrated that CL-K1 mRNA was expressed in all tissues tested. Immunohistochemical analyses demonstrated that CL-K1 was expressed in proximal tubules of kidney, in mucosa of the gastrointestinal tract, and in bronchial glands of bronchioles similar to the localization of SP-A and SP-D in these pulmonary structures. Immunohistochemistry also showed that CL-K1 was highly expressed in hepatocytes around the central veins in liver, which suggests that murine CL-K1 may be mainly produced in the liver and secreted into the blood stream as is human CL-K1. CL-K1 was especially detected in vascular smooth muscle in several types of tissues. In addition, it was also expressed in intestinal Paneth cells, in mesangial cells of kidney, in pancreatic islet D cells, and in neurons of the brain. It is of interest that this profile of CL-K1 expression is unique among the collectins. Together these histological findings may be useful for understanding the biological function of this novel collectin.

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“…Additionally, Arockiaraj et al (2015) reported that mannose-binding lectin (MBL) that mediates cellular recognition has also been reported. MBL is a class of protein with specific carbohydrate recognition such as sugar and plays an important role in the immune system (Drickamer et al, 1988;Medzhitov et al, 2002). Moreover, MOS can stimulate mannose receptors and MBL by liver secretion triggering a complete cascade stimulating the immune system of rainbow trout Oncorhynchus mykiss (Rodriguez-Estrada et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Microencapsulation of probiotics and its applications with prebiotic in Pacific white shrimp larvae through Artemia sp.

Ramadhani

Widanarni

Sukenda

2019

Jurnal Akuakultur Indonesia

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This study aimed to produce microencapsulated probiotic Pseudoalteromonas piscicida (1Ub) and evaluate it with prebiotic mannan-oligosaccharide (MOS) through the enrichment of Artemia sp., on bacterial population, growth performances, immune responses, and disease resistance of Pacific white shrimp larvae. Microencapsulation of probiotic was done by the freeze-drying method. The shrimp larvae were reared for 13 days and fed by the Artemia sp. enriched with microcapsule of probiotic 1Ub (10 g/L), prebiotic MOS (12 mg/L), synbiotic, and control without administration of microencapsulated probiotic and prebiotic, including negative (C-) and positive (C+) control. On the day 14, all of the experimental shrimp larvae except C- were challenged through immersion method with Vibrio harveyi MR5339 (107 CFU/mL). This study showed that the administration of microcapsule of probiotic 1Ub, prebiotic MOS, and synbiotic through the enrichment of Artemia sp. could increase the bacteria population, growth performances, immune responses, and disease resistance of Pacific white shrimp larvae. Moreover, synbiotic treatment demonstrated the best result compared to other treatments.Keywords: probiotic, prebiotic, synbiotic, Pacific white shrimp, microencapsulation ABSTRAKPenelitian ini bertujuan untuk membuat mikrokapsul probiotik Pseudoalteromonas piscicida (1Ub) dan mengevaluasinya dengan prebiotik mannan-oligosaccharides (MOS) melalui pengayaan Artemia sp. terhadap populasi bakteri, performa pertumbuhan, respons imun dan resistensi penyakit pada larva udang vaname. Mikroenkapsulasi probiotik dilakukan dengan metode freeze-drying. Larva udang dipelihara selama 13 hari dan diberi pakan Artemia sp. yang telah diperkaya dengan mikrokapsul probiotik 1Ub (10 g/L), prebiotik MOS (12 mg/L), sinbiotik, dan kontrol tanpa penambahan mikrokapsul probiotik dan prebiotik, termasuk kontrol negatif (C-) dan positif (C+). Pada hari ke-14, seluruh larva udang percobaan kecuali C- diuji tantang melalui metode perendaman dengan Vibrio harveyi MR5339 (107 CFU/mL). Hasil penelitian menunjukkan bahwa pemberian mikrokapsul probiotik 1Ub, prebiotik MOS, dan sinbiotik melalui pengayaan Artemia sp. dapat meningkatkan populasi bakteri, performa pertumbuhan, respons imun, dan resistensi penyakit pada larva udang vaname. Selain itu, perlakuan sinbiotik menunjukkan hasil terbaik dibandingkan perlakukan lainnya.Kata kunci : probiotik, prebiotik, sinbiotik, udang vaname, mikroenkapsulasi

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Two distinct classes of carbohydrate-recognition domains in animal lectins.

Cited by 1,162 publications

References 57 publications

Elasticity and energy dissipation in the double network hydrogel adhesive of the slug Arion subfuscus

Elasticity and energy dissipation in the double network hydrogel adhesive of the slug Arion subfuscus

Immunolocalization of a Novel Collectin CL-K1 in Murine Tissues

Microencapsulation of probiotics and its applications with prebiotic in Pacific white shrimp larvae through Artemia sp.

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