Two-dimensional transition metal dichalcogenide nanomaterials for combination cancer therapy

Abstract

In this review, we mainly summarize the latest advances in the utilization of 2D TMDCs for PTT combination cancer therapy and imaging-guided cancer combination therapy, as well as their toxicity bothin vitroandin vivo.

Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

“…Graphene‐like 2D layered TMDC is the most widely studied TMDC nanostructure in biomedical applications due to its large surface and low cytotoxicity, as well as superior physical and chemical properties . Up to now, a series of methods have been developed to synthesize 2D TMDC nanosheets.…”

“…Graphene-like 2D layered TMDC is the most widely studied TMDC nanostructure in biomedical applications due to its large surface and low cytotoxicity, as well as superior physical and chemical properties. [5,6,10,17,19] Up to now, a series of methods have been developed to synthesize 2D TMDC nanosheets. Among all the reported methods, traditional routes such as micromechanical cleavage and chemical vapor deposition are not suitable Small Methods 2017, 1, 1700220 for biological applications, especially for in vivo theranostic purposes, because the as-prepared TMDCs are usually large-sized and water insoluble.…”

“…The development of transition‐metal dichalcogenides (TMDCs) has remained a hot research topic over the last few decades . TMDCs, with the generalized formula of MX 2 , where M refers to a transitional metal typically from groups 4–10 (Ti, Nb, Ta, Mo, or W) of the periodic table and X is a chalcogen atom (S, Se, or Te), have been reported to possess diverse properties varying from insulating (e.g., HfS 2 ) and semiconducting (e.g., MoS 2 and WS 2 ) to semimetallic (e.g., WTe 2 and TiSe 2 ) as well as true metallic (e.g., NbS 2 and VSe 2 ) .…”

“…The development of transition-metal dichalcogenides (TMDCs) has remained a hot research topic over the last few decades. [1][2][3][4][5][6][7] TMDCs, with the generalized formula of MX 2 , where M refers to a transitional metal typically from groups 4-10 (Ti, Nb, Ta, Mo, or W) of the periodic table and X is a chalcogen atom (S, Se, or Te), have been reported to possess diverse properties varying that, by decreasing the particle size, the electronic bandgap and photoluminescence of TMDCs would correspondingly increase, which enables them to be applied in optical cellular observations as well as biosensors. [27][28][29][30] For instance, ion-intercalated MoS 2 can be used in cell-viability investigations, based on its photoluminescence.…”

Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging‐Guided Combinatorial Chemo‐Photothermal Therapy

“…Layered transition metal dichalcogenides (TMDs) nanomaterials, such as MoS 2 , WS 2 , and ReS 2 , have recently demonstrated tremendous opportunities for efficient PTA and drug delivery, [4f, 9] due to their high NIR absorbance, large surface areas, and better physiological stability than conventional two-dimensional nanomaterials. Nevertheless, the potential in vivo toxicity regarding these transition metals remains unclear.…”