Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

Zhu, Shuang; Gong, Lixin; Xie, Jiani; Gu, Zhanjun; Zhao, Yuliang

doi:10.1002/smtd.201700220

Cited by 93 publications

(64 citation statements)

References 173 publications

(289 reference statements)

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“…Future advancements in combination therapy between gas therapy and other treatment are expected to enhance the efficacy of gas therapy and simultaneously reduce the side effects of a single treatment. Last but not least, before these emerging delivery strategies can be used in clinical therapy, their physiological dispersibility and stability, biocompatibility, biodistribution as well as biosafety should be thoroughly evaluated by systematic studies . More worthy of mention, in order to achieve clinical translation of CO therapy, multidisciplinary collaboration would be essential.…”

Section: Resultsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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Section: Resultsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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“…During the past years, much effort was devoted to the exploration of TMDs‐based hybrid nanostructures for biomedical applications, including biological imaging, cancer therapy, antibacterial treatment, biosensing, and drug delivery . TMDs nanosheets not only had large specific surface area to load various biomolecules, medicines, and functional building blocks but were also biocompatible with negligible cytotoxicity . Despite these merits, the main challenge to constructing reliable TMDs‐based hybrid nanostructure for biomedical applications was building strong interfacial interactions because of the chemical inertness of TMDs.…”

Section: Coordination‐driven Assembly Based On Tmdsmentioning

confidence: 99%

Coordination‐Driven Hierarchical Assembly of Hybrid Nanostructures Based on 2D Materials

Liu

Zhong

Xie

2019

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nanobelts), 2D materials exhibit exceptional physical properties including large theoretical surface area, tunable electronic properties, high optical transparency, and excellent mechanical properties. [2] However, the strong re-stacking tendency of 2D materials caused by van der Waals interaction may result in serious loss of surface area, which inevitably weakens their unique properties. Besides, 2D materials always show intrinsic deficiencies for specific applications, despite the merits mentioned above. As a typical example, TMDs possess high theoretical specific capacities for lithium-ion storage but exhibit unsatisfied cyclability and rate capability in practice, because of their aggregation, low conductivity as well as huge volume expansion during lithium-ion insertion/extraction. [3] One effective way to solve these problems is to construct hybrid nanostructures based on 2D materials. [4][5][6][7][8] Hybrid nanostructures, as a class of composite materials, are composed of two or more nanostructured building blocks. [9,10] Hybrid nanostructures not only can energetically combine the intriguing merits and overwhelm the deficiencies of each building block, but also may generate new functions and properties. [3][4][5][6][7][8][11][12][13] These advantages make hybrid nanostructures based on 2D materials highly promising for practical applications with high performance. [14][15][16][17][18] Regarding the multicomponent composition of hybrid nanostructures, the interfacial interaction between the building blocks lays the foundation for structural and morphological stability, thereby influencing the functions and properties of the resulting hybrid nanostructures. [19][20][21][22] In this sense, the rational design and construction of reliable interfacial interaction for hybrid nanostructures are not only important for achieving improved performance, but also critical for understanding the fundamentals of structureproperty relationship.Generally, there are five types of interfacial interactions, i.e., covalent bond, coordination bond, hydrogen bond, π-π interaction, and electrostatic interaction. [19][20][21][22] Covalent bond and coordination bond are much stronger than the other three in terms of bond energy, so the former two are more favorable for constructing hybrid nanostructures with reliable interfacial interaction. [19] However, most 2D materials are chemically inert, which means the covalent modification is not suitable for them. Alternatively, there are coordination atoms in most of 2D materials and their derivatives, and hence coordination 2D materials have received tremendous scientific and engineering interest due to their remarkable properties and broad-ranging applications such as energy storage and conversion, catalysis, biomedicine, electronics, and so forth. To further enhance their performance and endow them with new functions, 2D materials are proposed to hybridize with other nanostructured building blocks, resulting in hybrid nanostructures with various morphologies and structures. The prop...

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“…Recent literature also witnessed an increasing interest in employing graphene analogs such as thin‐layer transition metal dichalcogenides (TMDs) as antibacterial materials. Thin‐layer molybdenum disulfide (MoS 2 ) that belongs to the thin‐layer TMDs family has been extensively employed for biomedical applications mainly due to the following reasons: 1) Its double‐sided S layer sandwiching the Mo layer offers scope for effective covalent or noncovalent modification with functional molecules; 2) Its unique optical properties make possible wavelength‐tunable, light‐driven photodynamic and photothermal therapies; 3) Recent long‐term in vivo studies suggested its low toxicity and biocompatibility for live animals . Bearing these merits in mind, here we report the construction of thin‐layer MoS 2 ‐based multivalent glycosheets for the targeted, light‐driven therapy (i.e., targeted bacterial immobilization, NIR‐light‐driven thermal release of antibiotics, and white light–driven reactive oxygen species [ROS] production— Figure ) of multidrug‐resistant P. aeruginosa on wounds.…”

Section: Introductionmentioning

confidence: 99%

Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug‐Resistant Bacteria on Wounds

Chu

Dong

et al. 2019

Adv Funct Materials

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With the evergrowing threat posed by multidrug resistance of bacteria, the development of effective antibacterial agents remains a global challenge. Infection with multidrug-resistant bacteria in hospitals significantly impairs the healing of wounds caused by deep-burn injuries or diabetic foot ulceration, leading to a high mortality rate among these patients. A multivalent glycosheet for the double light-driven therapy against multidrugresistant Pseudomonas aeruginosa (P. aeruginosa) infection on wounds is developed here. Galactose-and fucose-based ligands are self-assembled to form a glyco-layer on the surface of thin-layer molybdenum disulfide, producing the glycosheets capable of selectively localizing P. aeruginosa through multivalent carbohydrate-lectin interactions. The glycosheets loaded with antibiotics have proven applicable for: 1) near-infrared-light driven, in situ thermal release of antibiotics, increasing bacterial membrane permeability, and 2) white light-driven reactive-oxygen-species production to more thoroughly kill the bacteria. The targetability, together with the light sensibility, of the glycosheets enables a highly effective and optically controlled therapeutic regime for the healing of wounds infected by multidrug-resistant as well as clinically isolated P. aeruginosa.

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Design, Synthesis, and Surface Modification of Materials Based on Transition‐Metal Dichalcogenides for Biomedical Applications

Cited by 93 publications

References 173 publications

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Coordination‐Driven Hierarchical Assembly of Hybrid Nanostructures Based on 2D Materials

Multivalent Glycosheets for Double Light–Driven Therapy of Multidrug‐Resistant Bacteria on Wounds

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