We survey the thermodynamic stabilities and properties, electronic transports, and thermoelectric possibilities of two-dimensional (2D) ZnPS 3 and ZnPSe 3 , belonging to transition-metal phosphorus trichalcogenides, by employing the first-principles electronic structure calculation. Our first-principles calculation accompanying ab initio molecular dynamics and phonon calculation predicts that a single-layer (1L-) ZnPSe 3 would be thermodynamically stable; in addition, electron and hole mobilities of 1L-ZnPSe 3 amount to ∼440 and ∼400 cm 2 V −1 s −1 , respectively, which are comparable to 1L-MoS 2 . More interestingly, the lattice thermal conductivity of 1L-ZnPSe 3 is found to be lower than any other 2D material, which could reach the lowest, i.e., ∼0.13 W m −1 K −1 at room temperature. In contrast, the thermoelectric figure of merit of the pristine 1L-ZnPSe 3 is just ∼0.8 under optimal condition. Nevertheless, this is a very promising indication for a thermoelectric application of 1L-ZnPSe 3 because other elements to determine the thermoelectric figure of merit could be possibly engineered through a manipulation of underlying electronic structures. With this finding, 1L-ZnPSe 3 would be added as a novel promising candidate to a list of 2D thermoelectric materials.