Two different human papillomavirus (HPV) types associated with oral mucosal lesions in an HIV‐seropositive man

Abstract

Different types of Human papillomaviruses (HPV) are associated with a variety of oral lesions. So far, HPV types 1, 2, 4, 6, 7, 11, 13, 16, 18, 32 and 57 have been identified in oral lesions. Immunosuppression predisposes oral mucosa to clinical manifestation of different virus infections including HPV. We describe here a 30-year-old HIV-positive and immunosuppressed man, who had suffered from oral lesions for a few months. On clinical examination, a nodular elevation was detected on the lower lip, and white keratotic areas were present on buccal mucosa bilaterally. A biopsy from the lip revealed the presence of acanthosis with a prominent granular cell layer as well as hyperparakeratosis. A biopsy from the buccal lesion showed a comparatively much flatter lesion with merely basal cell hyperplasia associated with hyperparakeratosis. Koilocytosis was a characteristic feature in both biopsies. In Southern blot hybridization, both lesions hybridized with a probe cocktail comprising HPV 6, 11, 16, 18, 31 and 33 DNA under low stringency. Under high stringency, the lip lesion proved to contain HPV 7 DNA, which also confirmed by in situ hybridization. The buccal lesion was weakly positive by Southern blot with HPV 11 and 13 probes hybridized under stringent conditions, but the restriction patterns with Pst I and Bam HI did not fit with those of any of the 57 HPV types known so far. In situ hybridizations with HPV 11 and HPV 13 probes were negative. Cloning of this 'new' HPV type is currently under way.

Association of human papillomavirus 7 with warts in toe webs

“…Syrjänen et al. 19 reported a lip lesion in an HIV‐positive immunosuppressed man that proved to contain HPV 7 DNA, which was confirmed by in situ hybridization. HPV 7 was found for the first time in cutaneous warts on a nonfacial site and without associated oral lesions in an HIV‐infected patient who was not a butcher.…”

A papillomavirus related to HPV type 13 in oral focal epithelial hyperplasia in the pygmy chimpanzee

“…Occasionally, more dermatotrophic types (HPV I. 2 and 7) have been reported in oral warty lesions (6)(7)(8)(9), However, only HPV types 13 and 32. isolated from patients with PEH. have been found exclusively in the oral cavity (10.…”

Prevalence of Epstein‐Barr virus and human papillomavirus in oral mucosa of HIV‐Infected patients

“…Interestingly, three of the eight HPV-positive OHL specimens in our study were types other than the eom-m on mucosatropie types 6, 11, 16 and 18. Unusual HPV types, sueh as HPV 7, have been reported in the oral eavity of HIV-seropositive individuals (34,35). Although the OHL speeimens in our study and those of SNIDJERS et al (13) were from HIV-infeeted patients, there is no information available to compare the immune status of the patients in the two studies.…”