A papillomavirus related to HPV type 13 in oral focal epithelial hyperplasia in the pygmy chimpanzee

Abstract

An epizootic of focal epithelial hyperplasia (FEH) or Morbus Heck in a pygmy chimpanzee (Pan paniscus) colony is described. Papovavirus-like particles were observed in the nuclei of epithelial cells. Analysis of the DNA of the lesions revealed an episomal papillomavirus-specific band with a molecular size of approximately 8,000 bp. In situ hybridization under high stringency conditions showed cross-hybridization between the chimpanzee papillomavirus DNA and human papillomavirus (HPV) type 13. The latter virus is uniquely associated with oral disease in man. This is the first demonstration of the association of a HPV 13-related pygmy chimpanzee papillomavirus (PCPV) and oral epithelial hyperplasia in a nonhuman primate.

Characterization of a Novel Close-to-Root Papillomavirus from a Florida Manatee by Using Multiply Primed Rolling-Circle Amplification: Trichechus manatus latirostris Papillomavirus Type 1

“…Causes for immunologic suppression in manatees include low water temperature (4) and a reduction in population size. Reduced diversity of genes that mediate immune defenses, particularly the major histocompatibility complex genes, due to genetic bottlenecks can lead to increased population sensitivity to infectious agents (12), and an increased prevalence and severity of PV-related pathology is often seen in populations that went through a historic genetic bottleneck (15,20,21).…”

Characterization and Experimental Transmission of an Oncogenic Papillomavirus in Female Macaques

“…The high-risk oncogenic mucosal HPVs are members of the alpha-PV group, which collectively represents over half of the known HPV types (8). Related alpha-PVs have only been identified in other Old World primates, including macaques (6), colobus monkeys (20), and a pigmy chimpanzee (30). These reports are sporadic, however, and few studies have systematically evaluated and typed genital PVs across nonhuman primate populations (6,22).…”

Cell transformation by animal papillomaviruses

“…It is interesting that a papillomavirus isolated from skin lesions of a colobus monkey is related to the human cutaneous viruses HPV-5 and -8 (Kloster et al, 1988), and a papillomavirus isolated from the papillary lesions of the oral cavity of pigmy chimpanzees is related to HPV-13 (Van Ranst et al, 1991), the agent of oral focal epithelial hyperplasia in humans (Pfister et al, 1983), suggesting a close relationship between anatomical site and virus type in monkeys and in humans. Resza et al (1991) have isolated a second papillomavirus from colobus monkeys, which transforms established cells with the same frequency as BPV-1; it is not known whether this virus can transform primary cells.…”