Characterization and Experimental Transmission of an Oncogenic Papillomavirus in Female Macaques

Wood, Charles E.; Chen, Zigui; Cline, J. Mark; Miller, Brigitte; Burk, Robert D.

doi:10.1128/jvi.00233-07

Cited by 62 publications

(73 citation statements)

References 35 publications

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“…Four viral types were associated with cervical intraepithelial neoplasia (CIN), which resembles human CIN. Transfer of cervical cells positive for one of these high-risk papillomavirus types, which are closely related to the highly oncogenic HPV16, to uninfected monkeys resulted in new cervical infections and the development of abnormal cytology (Wood et al 2007). CIN and squamous cell carcinoma of the cervix resulted from sexual transmission of papillomavirus in a rhesus monkey (Ostrow et al 1990).…”

Section: Papillomavirus (Papillomaviridae)mentioning

confidence: 98%

Macaque Models of Human Infectious Disease

Gardner¹,

Luciw²

2008

ILAR Journal

171

133

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Macaques have served as models for more than 70 human infectious diseases of diverse etiologies, including a multitude of agents-bacteria, viruses, fungi, parasites, prions. The remarkable diversity of human infectious diseases that have been modeled in the macaque includes global, childhood, and tropical diseases as well as newly emergent, sexually transmitted, oncogenic, degenerative neurologic, potential bioterrorism, and miscellaneous other diseases. Historically, macaques played a major role in establishing the etiology of yellow fever, polio, and prion diseases. With rare exceptions (Chagas disease, bartonellosis), all of the infectious diseases in this review are of Old World origin. Perhaps most surprising is the large number of tropical (16), newly emergent (7), and bioterrorism diseases (9) that have been modeled in macaques. Many of these human diseases (e.g., AIDS, hepatitis E, bartonellosis) are a consequence of zoonotic infection. However, infectious agents of certain diseases, including measles and tuberculosis, can sometimes go both ways, and thus several human pathogens are threats to nonhuman primates including macaques. Through experimental studies in macaques, researchers have gained insight into pathogenic mechanisms and novel treatment and vaccine approaches for many human infectious diseases, most notably acquired immunodeficiency syndrome (AIDS), which is caused by infection with human immunodeficiency virus (HIV). Other infectious agents for which macaques have been a uniquely valuable resource for biomedical research, and particularly vaccinology, include influenza virus, paramyxoviruses, flaviviruses, arenaviruses, hepatitis E virus, papillomavirus, smallpox virus, Mycobacteria, Bacillus anthracis, Helicobacter pylori, Yersinia pestis, and Plasmodium species. This review summarizes the extensive past and present research on macaque models of human infectious disease.

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Section: Papillomavirus (Papillomaviridae)mentioning

confidence: 98%

Macaque Models of Human Infectious Disease

Gardner¹,

Luciw²

2008

ILAR Journal

171

133

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“…These phylogenetically related alpha-PV types can induce epithelial dysplasia of varying degrees, resembling the high-grade cervix intraepithelial neoplasia (CIN) associated with persistent HR mucosal-HPV infections, specifically within the alpha-9 species, which includes HPV16 [5,6,41]. Experimental transmission of MfPV-3 ( Macaca fascicularis PV-3) from a naturally infected female to naive female macaques was associated with the development of cervical intraepithelial neoplasia [42]. These nonhuman primate PVs are more similar to the alpha-9 HPV species, than more distantly related HPV types, such as the alpha-10 species, suggesting the mechanisms governing cellular transformation result from a common ancestral trait that predates human/primate divergence.…”

Section: Viral Identification and Classification: Phylogeny And Taxonomymentioning

confidence: 99%

Human Papillomavirus Genomics: Past, Present and Future

Harari

Chen

Burk³

2014

Current Problems in Dermatology

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“…Rhesus macaques, Maccaca mulatta, are the only species, other than human, in which infection with the natural PV, in this case rhesus papillomavirus type 1 (RhPV-1), which is closely related to HPV-16, is both sexually transmitted and gives rise to cervical neoplasia (Ostrow et al, 1991;de Villiers et al, 2004;Wood et al, 2007). Thus, it is a high-risk PV type, but examination of the E6 protein sequence showed no sign of a PDZbinding motif.…”

Section: A Lesson From Monkeysmentioning

confidence: 99%

Human papillomaviruses, cervical cancer and cell polarity

et al. 2008

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Human papillomaviruses (HPVs) are the causative agents of a number of human cancers, of which cervical cancer is the most important. This occurs following persistent infection with a limited number of viral subtypes and is characterized by continued expression of the viral E6 and E7 oncoproteins. A unique characteristic of the cancercausing HPV types is the presence of a PDZ recognition motif on the carboxy terminus of the E6 oncoprotein. Through this motif, E6 directs the proteasome-mediated degradation of cellular proteins involved in the regulation of cell polarity and in cell proliferation control. These include components of the Scrib and Par polarity complexes, as well as a number of other PDZ domaincontaining substrates. Thus, PVs are now providing novel insights into the functioning of many of these cellular proteins, and into which of these functions, in particular, are relevant for maintaining normal cellular homeostasis. In this review, we discuss the biological consequences of papillomaviral targeting of these cell polarity regulators, both with respect to the viral life cycle and, most importantly, to the development of HPV-induced malignancy.

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Characterization and Experimental Transmission of an Oncogenic Papillomavirus in Female Macaques

Cited by 62 publications

References 35 publications

Macaque Models of Human Infectious Disease

Macaque Models of Human Infectious Disease

Human Papillomavirus Genomics: Past, Present and Future

Human papillomaviruses, cervical cancer and cell polarity

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