Two different approaches to synthesizing Mg–Al-layered double hydroxides as folic acid carriers

Qin, Lili; Wang, Shilong; Zhang, Rui; Zhu, Rongrong; Sun, Xiaoyu; Yao, Side

doi:10.1016/j.jpcs.2008.06.144

Cited by 37 publications

(32 citation statements)

References 32 publications

(31 reference statements)

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“…The general formula of an LDH is: where "M 2+ " and "M 3+ " are divalent and trivalent metal cations, respectively, "A m-" refers to an interlayer anion with an m charge, n is the number of water molecules in the interlayer space, and x is the layer charge density. 14 Owing to the efficient drug-delivery feature of LDH nanocarriers, many pharmaceutically active compounds have been successfully intercalated into the interlayer gallery of LDH. Among them are the cardiovascular drugs fluvastatin and pravastatin; 15 anti-inflammatory drugs such as diclofenac 16 and fenbufen; 17 antihypertensive drugs like perindopril erbumine; 18,19 the antihistamine drug cetirizine hydrochloric acid; 20 and anticancer drugs such as cordycepin, which was intercalated into the gallery of magnesium/ aluminum (Mg/Al)-LDH.…”

Section: Introductionmentioning

confidence: 99%

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Barahuie¹,

Hussein²,

Hussein‐Al‐Ali³

et al. 2013

IJN

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Abstract:In the study reported here, magnesium/aluminum (Mg/Al)-layered double hydroxide (LDH) was intercalated with an anticancer drug, protocatechuic acid, using ionexchange and direct coprecipitation methods, with the resultant products labeled according to the method used to produce them: "PANE" (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the ion-exchange method) and "PAND" (ie, protocatechuic acid-Mg/Al nanocomposite synthesized using the direct method), respectively. Powder X-ray diffraction and Fourier transform infrared spectroscopy confirmed the intercalation of protocatechuic acid into the inter-galleries of Mg/Al-LDH. The protocatechuic acid between the interlayers of PANE and PAND was found to be a monolayer, with an angle from the z-axis of 8° for PANE and 15° for PAND. Thermogravimetric and differential thermogravimetric analysis results revealed that the thermal stability of protocatechuic acid was markedly enhanced upon intercalation. The loading of protocatechuic acid in PANE and PAND was estimated to be about 24.5% and 27.5% (w/w), respectively. The in vitro release study of protocatechuic acid from PANE and PAND in phosphate-buffered saline at pH 7.4, 5.3, and 4.8 revealed that the nanocomposites had a sustained release property. After 72 hours incubation of PANE and PAND with MCF-7 human breast cancer and HeLa human cervical cancer cell lines, it was found that the nanocomposites had suppressed the growth of these cancer cells, with a half maximal inhibitory concentration of 35.6 μg/mL for PANE and 36.0 μg/mL for PAND for MCF-7 cells, and 19.8 μg/mL for PANE and 30.3 μg/mL for PAND for HeLa cells. No half maximal inhibitory concentration for either nanocomposite was found for 3T3 cells.

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Section: Introductionmentioning

confidence: 99%

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Barahuie¹,

Hussein²,

Hussein‐Al‐Ali³

et al. 2013

IJN

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“…Assuming a thickness of 0.48 nm for the brucite-like layer of LDH, the gallery height in folic acid-LDH became 0.70 nm, which is shorter than the molecular length of folic acid (~2.15 nm). 20,26 The reason for the discrepancy between the calculated gallery height (0.70 nm) and estimated molecular length (~2.15 nm) is the strong electrostatic interactions between folic acid anions and LDH hydroxide layers. It also can be deduced that the folic acid molecules are arranged in a tilted longitudinal monolayer, with tilting angles of approximately 70°.…”

Section: Results and Discussion Preparation And Characterization Of Fmentioning

confidence: 98%

“…Thus, in this study, the preparation procedure offers a much higher drug-loading amount compared to our previous study. 20 Physicochemical characteristics of folic acid-lDh TEM samples were prepared by adding 300 mL of LDH and folic acid-LDH slurry (0.5 mg/mL) to 15 mL of deionized water followed by probe sonication of the solution for 2 minutes. A drop of the solution was then placed on a holey carbon copper grid and air dried.…”

Section: Results and Discussion Preparation And Characterization Of Fmentioning

confidence: 99%

“…20 A mixed solution (40 mL) of 0.17 M NaOH and 0.1 M folic acid was stirred at room temperature for 10 minutes, and then a solution (10 mL) containing 0.3 M Mg(NO 3 ) 2 and 0.1 M Al(NO 3 ) 3 was added. The mixture was continuously vigorously magnetically stirred under N 2 for 3 hours.…”

Section: Preparation Of Folic Acid-ldhmentioning

confidence: 99%

“…20 In the present study, folic acid-LDH was prepared according to a previous method with some modifications. Our goal here is to examine the in vitro antioxidative capacity of folic acid-LDH as well as its in vivo antifatigue effects.…”

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confidence: 99%

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In vitro antioxidant activity and in vivo antifatigue effect of layered double hydroxide nanoparticles as delivery vehicles for folic acid

Qin

Wang

You

et al. 2014

IJN

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Folic acid antioxidants were successfully intercalated into layered double hydroxides (LDH) nanoparticles according to a previous method with minor modification. The resultant folic acid-LDH constructs were then characterized by X-ray powder diffraction and transmission electron microscopy. The in vitro antioxidant activities, cytotoxicity effect, and in vivo antifatigue were examined by a series of assays. The results showed that folic acid-LDH antioxidant system can scavenge 1,1-diphenyl-2-picrylhydrazyl and hydroxyl free radicals and chelate pro-oxidative Cu 2+ . The in vitro cytotoxicity assays indicated that folic acid-LDH antioxidant system had no significant cytotoxic effect or obvious toxicity to normal cells. It also prolonged the forced swimming time of the mice by 32% and 51% compared to folic acid and control groups, respectively. It had an obvious effect on decreasing the blood urea nitrogen and blood lactic acid, while increasing muscle and hepatic glycogen levels. Therefore, folic acid-LDH might be used as a novel antioxidant and antifatigue nutritional supplement.

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A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides

et al. 2010

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Two different approaches to synthesizing Mg–Al-layered double hydroxides as folic acid carriers

Cited by 37 publications

References 32 publications

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

Preparation and controlled-release studies of a protocatechuic acid-magnesium/aluminum-layered double hydroxide nanocomposite

In vitro antioxidant activity and in vivo antifatigue effect of layered double hydroxide nanoparticles as delivery vehicles for folic acid

A sustained folic acid release system based on ternary magnesium/zinc/aluminum layered double hydroxides

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