Two Decades of Universal Hepatitis B Vaccination in Taiwan: Impact and Implication for Future Strategies

Ni, Yen‐Hsuan; Huang, Li‐Min; Chang, Mei–Hwei; Yen, Chung–Jen; Lu, Chun Yi; You, San–Lin; Kao, Jia‐Horng; Lin, Yu–Chen; Chen, Huey–Ling; Chen, Ding‐Shinn

doi:10.1053/j.gastro.2007.02.055

Cited by 304 publications

(236 citation statements)

References 32 publications

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“…It is likely that HBV vaccination for children and risk groups would be as effective as found previously elsewhere e.g. in Taiwan or the United States 15 .…”

Section: Figurementioning

confidence: 68%

Case histories of infectious disease management in developing countries: Phnom Penh and Kabul

Pilsczek

2009

Rev. Soc. Bras. Med. Trop.

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Healthcare in developing countries is affected by severe poverty, political instability and diseases that may be of lesser importance in industrialized countries. The aim of this paper was to present two cases and histories of physicians working in hospitals in developing countries and to discuss the opportunities for clinical investigation and collaboration. Cases of patients in Phnom Penh, Cambodia, with histoplasmosis, cryptococcal meningitis, crusted scabies, cerebral lesions and human immunodeficiency virus and of patients in Kabul, Afghanistan, with liver cirrhosis, nephrotic syndrome and facial ulcer are discussed. Greater developmental support is required from industrialized nations, and mutually beneficial cooperation is possible since similar clinical problems exist on both sides (e.g. opportunistic cardiovascular infections). Examples for possible support of hospital medicine include physician interchange visits with defined objectives (e.g. infection control or echocardiography training) and collaboration with clinical investigations and projects developed locally (e.g. epidemiology of cardiovascular diseases or nosocomial bloodborne infections). Key-words:Developing countries. Infectious diseases. Collaboration. Cambodia. Afghanistan. RESUMOA assistência à saúde em países em desenvolvimento é afetada pela pobreza extrema, instabilidade política e doenças que podem ter menor importância em países industrializados. O objetivo deste trabalho foi apresentar dois casos e histórias de médicos que trabalham em hospitais de países em desenvolvimento e discutir as oportunidades de investigação clínica e cooperação. São discutidos casos de pacientes em Phnom Penh, no Camboja, com histoplasmose, meningite criptocócica, sarna, lesões cerebrais e vírus da imunodeficiência humana, e de pacientes em Kabul, no Afeganistão, com cirrose hepática, síndrome nefrótica e úlcera facial. Maior apoio ao desenvolvimento por parte dos países desenvolvidos é essencial, e uma cooperação mutuamente benéfica é possível, visto que problemas clínicos similares existem em ambos os lados (p. ex. infecções cardiovasculares oportunistas). Exemplos para possível apoio à medicina hospitalar incluem intercâmbio de médicos para visitas com objetivos definidos (p. ex. controle de infecção ou treinamento em ecocardiografia) e colaboração com investigações clínicas e projetos desenvolvidos localmente (p. ex. epidemiologia de doenças cardiovasculares ou infecções hospitalares causadas por via sanguínea). Palavras-chaves:Países em desenvolvimento. Doenças infecciosas. Colaboração. Camboja. Afeganistão.

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“…It is likely that HBV vaccination for children and risk groups would be as effective as found previously elsewhere e.g. in Taiwan or the United States 15 .…”

Section: Figurementioning

confidence: 68%

Case histories of infectious disease management in developing countries: Phnom Penh and Kabul

Pilsczek

2009

Rev. Soc. Bras. Med. Trop.

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“…The advances in the prevention of HBV transmission have yielded encouraging results. Taiwan introduced an HBV vaccination program in 1988, and HBIG was additionally given to infants of HBeAg-positive mothers [20,42,43]. In 2004, a survey showed seropositive rates for HBsAg, antiHBs, and anti-HBc of 1.2, 50.5, and 3.7%, respectively, in individuals born since the introduction of the vaccination program (i.e., individuals younger than 20 years).…”

Section: Prevention Of Mother-to-child Transmissionmentioning

confidence: 99%

“…Early infant infection seldom manifests as symptomatic acute hepatitis but evolves to chronic infection. Evidence from long-term follow-up studies on the impact of the implementation of universal HBV vaccination programs in Taiwan has clearly demonstrated that the prevention of mother-to-child transmission is the mainstay for the control of HBV infection in the AsiaPacific region [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Chronic hepatitis B in Asian women of childbearing age

Leung

2009

Hepatol Int

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Hepatitis B virus (HBV) infection is a serious clinical problem affecting approximately 2 billion people worldwide. An estimated 350 million live with chronic hepatitis B (CHB) infection and are at an increased risk for serious liver sequelae and death from acute or chronic consequences of CHB infection. Individuals with CHB have a 20-30% risk of early death from complications, including liver cirrhosis and hepatocellular carcinoma. In the Asia-Pacific region, half of the CHB burden results from vertical or mother-to-child transmission, with early childhood horizontal transmission accounting for the remaining half. Screening and vaccination are key factors in the successful prevention and control of HBV infection. Over the last 20 years, the implementation of screening programs and universal HBV vaccination for all individuals born in endemic areas have reduced the prevalence of HBV infection and HBV-related liver diseases among individuals younger than 30 years. Women of childbearing age are key stakeholders in preventing HBV infection and, as such, play a critical role in reducing the vertical and horizontal transmission of HBV. Further efforts are needed to implement screening and educational programs for women of childbearing age, particularly those with CHB, to prevent the transmission of HBV to newborns, spouses, other household members, and sexual partners. In addition, healthcare workers need to learn how to avoid iatrogenic transmission in the healthcare setting. This article reviews these issues and highlights areas in which their engagement with public health efforts serves to improve quality of life and society as a whole.

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“…The HBsAg carrier rate in the children of Taipei City decreased from 11% in 1984 46 to approximately 1% in 1989, 47 1994, 48 1999, 49 and 2004. 50 Results of the 2009 survey showed this figure to be 0.9%, and the decrease in the population has extended to adults 25 years of age (unpublished results). Similar results were also found in other places of Taiwan.…”

Section: Effectiveness Of Mass Hepatitis B Vaccination In the Decreasmentioning

confidence: 99%

Fighting against viral hepatitis: Lessons from Taiwan

Chen

2011

Hepatology

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Two Decades of Universal Hepatitis B Vaccination in Taiwan: Impact and Implication for Future Strategies

Cited by 304 publications

References 32 publications

Case histories of infectious disease management in developing countries: Phnom Penh and Kabul

Case histories of infectious disease management in developing countries: Phnom Penh and Kabul

Chronic hepatitis B in Asian women of childbearing age

Fighting against viral hepatitis: Lessons from Taiwan

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