Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990-2010

Weinberger, Andrea H.; Mazure, Carolyn M.; Paredes, Alejandra Morlett; McKee, Sherry A.

doi:10.1093/ntr/nts213

Cited by 86 publications

(99 citation statements)

References 154 publications

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“…Although reduction differed by medication, we found no evidence of a particularly strong effect of varenicline as previously described [12]. The present findings extend the evidence on the association between depression and subsequent smoking abstinence by focusing on the current level of depression diagnosed using a validated and well-established measure and by including mild depression as well as more severe depression [16]. In an earlier sample from the clinic used in the present study, a history of depression was not associated with abstinence [24], underlining the importance of assessment of depressive symptoms close to the quit attempt.…”

Section: Discussionsupporting

confidence: 79%

“…There was no evidence of differential effects by gender as found in previous studies [16,17]. As in previous findings on effectiveness [31] and efficacy [32], pharmacotherapy use in this clinic mostly predicted higher abstinence than no medication.…”

Section: Discussionsupporting

confidence: 59%

“…Having experienced depression and pre-cessation depressed mood have also been found to be associated with increased relapse [14,15]. In older smokers (not all of whom were attempting to quit), level of depression predicted continued smoking [11], and there is evidence across all ages that the negative effect of depression on cessation is stronger for women [16,17].…”

Section: Introductionmentioning

confidence: 99%

“…One limitation of the extant research on depression as predictor of cessation success is that studies generally looked at smokers with a history of (major) depression. This has led to several calls for more research into the association between current symptoms or current depression, including mild depression [16,19,20]. Many studies explicitly exclude smokers using antidepressants; thus, it remains unclear if smokers taking antidepressants respond as well to smoking cessation treatments as other smokers [16].…”

Section: Introductionmentioning

confidence: 99%

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Depression and Smoking Cessation: Evidence from a Smoking Cessation Clinic with 1-Year Follow-Up

et al. 2016

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Background Smoking is more prevalent among people with depression. Depression may make cessation more difficult and cessation may affect depression symptoms. Purpose The aims of this study were to assess the associations between (1) baseline depression and 1-year smoking abstinence and (2) abstinence and change in depression. Methods Observational study using data collected routinely in a smoking cessation clinic in the Czech Republic from 2008 to 2014. Aim 1: N = 3775 patients; 14.3% reported mild and 15.4% moderate/severe baseline depression levels measured using Beck's Depression Inventory (BDI-II). Logistic regressions assessed if depression level predicted 1-year biochemically verified abstinence while adjusting for patient and treatment characteristics. Aim 2: N = 835 patients abstinent at 1 year; change in depression was analysed using Chi-square statistics, t test and mixed method analyses of variance. Results Rate of abstinence was lower for patients with mild (32.5%, OR = 0.68; 95% CI: 0.54 to 0.87, p = 0.002) and moderate/severe depression (25.8%; OR = 0.57, 95% CI: 0.45 to 0.74, p < 0.001) compared with patients without depression (40.5%).Across abstinent patients, the majority with baseline depression reported lower depression levels at follow-up. Overall mean (SD) BDI-II scores improved from 9.2 (8.6) to 5.3 (6.1); t(834) = 14.6, p < 0.001. There were significant main effects of time (F(1832) = 880.8, p < 0.001, partial η 2 = 0.51) and baseline depression level (F(2832) = 666.4, p < 0.001, partial η 2 = 0.62) on follow-up depression and a significant depression * time interaction (F(2832) = 296.5, p < 0.001, partial η 2 = 0.42). Conclusions In this effective smoking cessation clinic, depression at the start of treatment predicted reduced smoking abstinence 1 year later. Patients abstinent from smoking experienced considerable improvement in depression.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Depression and Smoking Cessation: Evidence from a Smoking Cessation Clinic with 1-Year Follow-Up

et al. 2016

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“…Some smokers try to find relief from negative and undesirable feelings in the cigarettes and, thus, tobacco for these people can be a positive reinforcer 27 . The relationship between smoking and depression has not been investigated yet to determine the real meaning of cause-effect between tobacco and depression, as well as the adequate treatment 9,28 .…”

Section: Discussionmentioning

confidence: 99%

Nicotine dependence and levels of depression and anxiety in smokers in the process of smoking cessation

Pawlina¹,

Rondina²,

Espinosa³

et al. 2014

Rev. psiquiatr. clín.

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Background: Depression and anxiety are psychiatric disorders that are related to tobacco use and associated with dependence, the process of cessation, lapses and relapses after quitting smoking. Objective: To analyze the association of nicotine dependence with the level of anxiety and depression in patients who are in the process of smoking cessation. Methods: Cross-sectional study conducted with patients who sought the smoking cessation program in Cuiabá/MT. All the smokers enrolled from May to August 2012, participated in this study. Four instruments were applied: Socio-demographic Questionnaire, Fagerström test, Beck Anxiety Inventory and Beck Depression Inventory. Following bivariate analysis, using the crude prevalence ratio, with level of significance lower than 5% (p < 0.05), having as variable outcome the nicotine dependence ≥ 5 (Fagerström). The associations with p < 0.20 were selected for robust Multiple Poisson Regression (RP a ). Results: Associations of Fagerström ≥ 5 with the male sex (RP = 1.15 CI 95% 1.03-1.28); number of cigarettes/day (RP = 1,33; CI 95% 1.19-1.48); and moderate/severe level of depression (RP = 1.15; CI 95% 1.04-1.28) were found. In the final model (RPa), the following variables remained associated: male gender (RPa 1.12; CI 95% 1.01-1.24), number of cigarettes/day (RPa 1.28; CI 95% 1.15-1.43) and high level of depression (RPa 1.12; CI 95% 1.01-1.23). Discussion: High level of nicotine dependence was associated significantly with the level of depression, emphasizing the association between smoking and psychiatric comorbidities.

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Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents

Lippard

Mazure

Johnston

et al. 2016

J of Neuroscience Research

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Substance use disorders (SUDs) and mood disorders are highly comorbid and confer a high risk for adverse outcomes. However, data are limited on the neurodevelopmental basis of this comorbidity. Substance use initiation typically occurs during adolescence and sex-specific developmental mechanisms are implicated. In this preliminary study we review the literature and investigate regional gray matter volume (GMV) associated with subsequent substance use problems in adolescents with bipolar disorder (BD) and explore these associations for females and males. Thirty DSM-IV diagnosed BD adolescents with minimal alcohol/substance exposure completed baseline structural magnetic resonance imaging scans. At follow-up (on average 6 years post-baseline), subjects were administered the CRAFFT interview and categorized into those scoring at high (>2: CRAFFTHIGH) versus low (<2: CRAFFTLOW) risk for alcohol/substance problems. Lower GMV in prefrontal, insular, and temporopolar cortices were observed at baseline among adolescents with BD reporting subsequent alcohol and cannabis use compared to adolescents with BD who did not (p<0.005, clusters >20 voxels). Lower dorsolateral prefrontal GMV was associated with future substance use in both females and males. In females, lower orbitofrontal and insula GMV was associated with future substance use; while in males, lower rostral prefrontal GMV was associated with future use. Lower orbitofrontal, insular and temporopolar GMV was observed in those who transitioned to smoking tobacco. Findings indicate GMV development is associated with risk for future substance use problems in adolescents with BD, with results implicating GMV development in regions subserving emotional regulation in females and regions subserving executive processes and attention in males.

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Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990-2010

Cited by 86 publications

References 154 publications

Depression and Smoking Cessation: Evidence from a Smoking Cessation Clinic with 1-Year Follow-Up

Depression and Smoking Cessation: Evidence from a Smoking Cessation Clinic with 1-Year Follow-Up

Nicotine dependence and levels of depression and anxiety in smokers in the process of smoking cessation

Brain circuitry associated with the development of substance use in bipolar disorder and preliminary evidence for sexual dimorphism in adolescents

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