Two cases of scleredema with pituitary–adrenocortical neoplasms: An underrecognized skin complication

Oyama, Noritaka; Togashi, Ari; Kaneko, Fumio; Yamamoto, Toshiyuki

doi:10.1111/j.1346-8138.2011.01240.x

Cited by 5 publications

(5 citation statements)

References 7 publications

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“…SAB belongs to the group of cutaneous mucinoses and can be associated with bacterial, viral, hematological disorders, diabetes and other endocrine disorders. 37 , 44 Three scleredema variants are classically described. 45…”

Section: Sclerodermiform Disordersmentioning

confidence: 99%

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Diabetes mellitus and the skin

Mendes¹,

Miot²,

Haddad³

2017

An. Bras. Dermatol.

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Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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Section: Sclerodermiform Disordersmentioning

confidence: 99%

“… 48 This type tends to persist for years and may be at increased risk for multiple myeloma, being associated with other diseases such as amyloidosis, rheumatoid arthritis, Sjögren’s syndrome, obstructive sleep apnea, primary hyperparathyroidism, pituitary adenoma and adrenocortical disease. 40 , 44 , 49 , 50…”

Section: Sclerodermiform Disordersmentioning

confidence: 99%

Diabetes mellitus and the skin

Mendes¹,

Miot²,

Haddad³

2017

An. Bras. Dermatol.

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“…The third subtype, accounting for 20% of cases, is termed as scleredema diabeticorum and is associated with poorly controlled diabetes 3. There are rare case reports of scleredema associated with solid organ malignancies 4. Types 1 and 2 seem to affect women approximately twice as often as men, while type 3 occurs more frequently in men 3.…”

Section: Discussionmentioning

confidence: 99%

Face and neck swelling in a 16-year-old boy

et al. 2012

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SummaryScleredema adultorum is a rare condition characterised by progressive collagen and mucin deposition in the skin. While the aetiology has not been clearly delineated, the condition is often associated with common infections. The current report describes a previously healthy 16-yearold boy who presented with 3 weeks of progressive neck swelling and skin induration. He had evidence of both active streptococcal and Ebstein-Barr virus (EBV) infections. Skin biopsy confirmed the diagnosis of scleredema. The patient was treated for his streptococcal infection, but otherwise managed conservatively. Clear improvement in the signs and symptoms was seen at a 3-month follow-up appointment. Scleredema can be a complication of streptococcal infection but to our knowledge has not been reported in association with EBV. It should be considered in the differential diagnosis of any patient presenting with cutaneous/subcutaneous induration and swelling of the face and/or neck. BACKGROUND

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“…115 Scleroedema can be associated with several other systemic diseases like rheumatoid arthritis, [116][117][118] ankylosing spondylitis, 108 Sjögren's syndrome, 118 dermatomyositis, 119 hyperparathyroidism, 120,121 hypothyroidism, 122 Waldenström's macroglobulinaemia, anaphylactoid purpura, primary biliary cirrhosis, 123 IgA deficiency, 124 human immunodeficiency virus infection, 125 and pyoderma gangrenosum. 126 Cases of concomitant neoplasms have been reported, such as malignant insulinoma, 127 gall bladder carcinoma, 128 carcinoid tumour, 129 adrenocorticotropic hormone-producing pituitary tumour 130 and ovarian/breast carcinoma. 131,132 In type 1 and 2 scleroedema, women are affected almost twice as frequently as men.…”

Section: Epidemiology and Pathogenesismentioning

confidence: 99%

Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxoedema and scleroedema

Knobler,

Geroldinger‐Simić,

Kreuter

et al. 2024

Acad Dermatol Venereol

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The term ‘sclerosing diseases of the skin’ comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present consensus provides an update to the 2017 European Dermatology Forum Guidelines, focusing on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. In addition, updated strategies for the first‐ and advanced‐line therapy of sclerosing skin diseases are addressed in detail. Part 2 of this consensus provides clinicians with an overview of the diagnosis and treatment of scleromyxoedema and scleroedema (of Buschke).

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Two cases of scleredema with pituitary–adrenocortical neoplasms: An underrecognized skin complication

Cited by 5 publications

References 7 publications

Diabetes mellitus and the skin

Diabetes mellitus and the skin

Face and neck swelling in a 16-year-old boy

Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 2: Scleromyxoedema and scleroedema

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