2017
DOI: 10.1590/abd1806-4841.20175514 View full text |Buy / Rent full text
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Abstract: Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.

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“…Contudo, devido à sua relação significativa com o diagnóstico de DM (75-90% dos doentes com NL tem ou irá desenvolver DM tipo 1), pensa-se que sua origem pode estar relacionada a uma microangiopatia [1][2][3]12]. A NL é então considerada uma das formas de dermatose que ocorrem em associação com DM [3,5,13].…”
Section: Discussionunclassified
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“…Contudo, devido à sua relação significativa com o diagnóstico de DM (75-90% dos doentes com NL tem ou irá desenvolver DM tipo 1), pensa-se que sua origem pode estar relacionada a uma microangiopatia [1][2][3]12]. A NL é então considerada uma das formas de dermatose que ocorrem em associação com DM [3,5,13].…”
Section: Discussionunclassified
“…Estudos prévios demonstraram que o prognóstico da NL parecia ser independente do curso da DM e que o controle glicêmico estaria relacionado com o início e a gravidade da lesão [1,13]. Contudo, novos estudos já começam a estabelecer uma relação entre a existência de um mau controle metabólico e o desenvolvimento de NL.…”
Section: Discussionunclassified
“…Dermatology Some skin conditions may be an indicator of the presence of T2D in children and adolescents. The most common of these is acanthosis nigricans (AN), which is skin hyperpigmentation affecting the armpits, neck folds, flexor skin muscles, and umbilicus [19][20][21] (Fig. 1).…”
Section: Less-known Comorbid Associations With Youth-onset T2dmentioning
“…Other diabetes-associated dermatological conditions are rare in children, but could be warning indicators. These include granuloma annulare [21,22], necrobiosis lipoidica diabeticorum [20][21][22], and scleredema [20]. Granuloma annulare consists of small circular patches of pink/purple skin, up to 5 cm in diameter, and necrobiosis lipoidica diabeticorum causes yellowbrown skin plaques with an atrophied center [22].…”
Section: Less-known Comorbid Associations With Youth-onset T2dmentioning
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