Two Cases of Malignant Schwannoma of the Stomach

Ohmine, Yasushi; Miyagi, Jun; Nagayoshi, Seiji; Chibana, Tomomi; Yara, Isao

doi:10.3919/ringe1963.57.2708

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“…The incidence of malignant gastric schwannoma is reported to be about 10-15% of gastric schwannomas, while the incidence of metastasis is reported to be about 2.7% of patients with histopathologically diagnosed benign schwannomas [16]. Gastric schwannomas may be considered to be potentially malignant tumors, such as GIST.…”

Section: Discussionmentioning

confidence: 98%

Schwannoma of the stomach with elevated preoperative serum carbohydrate antigen 19-9: report of a case

et al. 2011

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We herein report a case of a gastric schwannoma with elevated preoperative serum carbohydrate antigen 19-9 (CA19-9) (155.2 U/ml, normal range 0-36.9 U/ml). A 59-year-old Japanese man was admitted to our hospital for treatment of a submucosal tumor of the stomach detected by barium meal, upper gastrointestinal endoscopy, and computed tomography. Endoscopic examination revealed a 3-cm diameter submucosal tumor in the antrum of the stomach, but biopsy of the lesion was unable to confirm the diagnosis. Positron emission tomography to evaluate the malignant potential showed a high uptake of (18)F-fluorodeoxyglucose in the tumor. Laparoscopy-assisted distal gastrectomy was therefore performed. The histopathological findings of the surgical specimen revealed a benign gastric schwannoma, positive for S-100 protein. The postoperative serum CA19-9 levels gradually decreased and normalized. To the best of our knowledge, this is the first report of a gastric schwannoma with elevated serum CA19-9.

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Section: Discussionmentioning

confidence: 98%