Two cases of familial Mediterranean fever associated with sarcoidosis (Lofgren's syndrome) and rheumatoid arthritis

Familial Mediterranean fever: What associations to screen for?

“…This association is increasingly reported in the world literature [35][36][37][38][39], and a significantly higher frequency of anti-citrullinated protein antibodies (ACPA) (specific for rheumatoid arthritis) has been found in patients with FMF: 14.5% vs. only 4.7% in the general population (3 times higher); their presence was significantly associated with arthritis during FMF [40].…”

“…Other rarer associations have been reported, with: systemic lupus erythematosus [46][47][48], sarcoidosis [38], Blau syndrome [49], Kartagener syndrome [50], Gitelman syndrome [51], Fabry syndrome [52], celiac disease [53], polymyositis [54], juvenile dermatomyositis [55], beta-thalassemia [56], atrophic polychondritis [57], fibromyalgia [58], eosinophilic gastroenteritis [59], and tumor necrosis factor receptor-1 syndrome (TRAPS syndrome) [60].…”

Are systemic lupus erythematosus patients carrying MEFV gene less prone to renal involvement? Report of three cases and review of the literature

“…12 There is a tendency for inflammation in the carriers of MEFV mutation and the prevalence of Crohn's disease, seronegative spondyloarthritis, Behçet's disease, HenochSchönlein purpura, polyarteritis nodosa and protracted febrile myalgia have been found to be increased in carriers of MEFV gene. 21 On the contrary, although SLE is also an autoimmune inflammatory disease, FMF can be a protective factor against SLE. This can be caused by high levels of CRP and serum amyloid P, which is thought to have a role in the catalysis of autoantigens and disposal of apoptotic material, so protecting from immune complex-mediated renal injury.…”