Are systemic lupus erythematosus patients carrying MEFV gene less prone to renal involvement? Report of three cases and review of the literature

Erten, Şükran; Taşkaldıran, Işılay; Yakut, Zeynep İlerisoy

doi:10.3109/0886022x.2013.809096

Cited by 8 publications

(10 citation statements)

References 18 publications

(23 reference statements)

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“…These findings are opposed to previous studies speculating that FMF was in a way “protective” by preventing coexistent SLE. 6 It has been postulated that the elevated CRP and serum amyloid P levels as occur from time to time in patients with FMF, may abrogate the catalysis of autoantigens and the disposal of apoptotic material, hence leading to minimizing the effect of the immune complex-mediated injury. 16…”

Section: Discussionmentioning

confidence: 99%

“…FMF typically affects Jews of Sephardic origin with a mutation carrier rate of 25% and 15–20% in Jews of Iraqi and North African descent respectively. 6,7…”

Section: Introductionmentioning

confidence: 99%

“…The literature on this topic is inconsistent and based mostly on case reports. 6,8–10 Clinical symptoms and findings of FMF, occur as a result of autoinflammation of the serous membranes which are often inflamed in patients with SLE as well. Because of a remarkable overlap between FMF and SLE symptoms, difficulties are sometimes encountered in the differential diagnosis of FMF 11 (Table 1).…”

Section: Introductionmentioning

confidence: 99%

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The coexistence of familial Mediterranean fever (FMF) in systemic lupus erythematosus (SLE) patients – A cross sectional study

Klein

Tiosano

Gilboa

et al. 2021

Lupus

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Background Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease characterized by antibody production against a myriad of autoantigens. Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder, triggered by FMF-associated point genes mutations. It has been hypothesized that the two conditions rarely coexist. Aim The aim of this study was to examine the proportions of FMF among SLE patients compared with the general population without SLE. We hypothesized that the proportion of FMF among SLE patients might be higher than the general population. Methods To conduct this cross-sectional study, data of adult patients with a physician diagnosis of SLE were retrieved from Clalit Health Services database, the largest Health Maintenance Organization in Israel, serving 4,400,000 members. Chi-square and T-test was used for univariate analysis. Results The study population included 4,886 SLE patients and 24,430 age and sex matched controls. Within the SLE group we detected a significantly higher proportion of FMF patients compared with non-SLE controls (0.68% and 0.21% respectively; p < 0.001). Conclusions Our study indicated that FMF is more prevalent in an Israeli population of SLE patients.

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Section: Discussionmentioning

confidence: 99%

“…FMF typically affects Jews of Sephardic origin with a mutation carrier rate of 25% and 15–20% in Jews of Iraqi and North African descent respectively. 6,7…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The coexistence of familial Mediterranean fever (FMF) in systemic lupus erythematosus (SLE) patients – A cross sectional study

Klein

Tiosano

Gilboa

et al. 2021

Lupus

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“…To our knowledge, there have been only 21 published cases, including our case, on the coexistence of FMF and SLE as shown in Table SI 1 (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Only 2 cases, including ours, are male patients, probably due to the low male-tofemale ratio in SLE.…”

Section: Systemic Lupus Erythematosus With Familial Mediterranean Fevmentioning

confidence: 99%

Systemic Lupus Erythematosus with Familial Mediterranean Fever: Case Report and Review of Literature

Kokubu¹,

Ida²,

Tanaka³

et al. 2019

Acta Derm Venerol

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“…In this group of patients anti IL-1 drugs like anakinra, canakinumab or rinolacept could be used [14]. Canakinumab is the only biologic agent approved by the U.S. FDA for the treatment of FMF [17] FMF could be associated with other autoimmune diseases such as ankylosing spondylitis, rheumatoid arthritis, polyarteritis nodosa, Behcet, multiple sclerosis, and Systemic Lupus, Henoch-Schönlein purpura, and Hashimoto's thyroiditis [18,19]. Association of type 1 diabetes mellitus (T1D) and FMF has been newly reported in the medical literature [20,21].…”

Section: Introductionmentioning

confidence: 99%

A case report of a boy suffering from Type 1 Diabetes Mellitus and Familial Mediterranean Fever

Gicchino

Iafusco

Zanfardino

et al. 2020

Preprint

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Background: Type 1 diabetes mellitus could be associated with other autoimmune diseases, such as autoimmune thyroid disease, celiac disease, but the association with Familial Mediterranean Fever is rare, we describe a case of a boy with type 1 Diabetes Mellitus associated with Familial Mediterranean Fever (FMF)Case presentation: A 13 year old boy already suffering from Diabetes Mellitus type 1 since the age of 4 years, came to our attention because of periodic fever associated with abdominal pain, chest pain and arthralgia. The fever appeared every 15-30 days with peaks that reached 40°C and lasted 24-48 hours. Laboratory investigation, were normal between febrile episodes, but during the attacks revealed an increase in inflammatory markers. Suspecting Familial Mediterranean Fever molecular analysis of MEFV gene, was performed. The genetic analysis showed homozygous E148Q mutation. So Familial Mediterranean Fever was diagnosed and colchicine treatment was started with good response.Conclusion. Familial Mediterranean Fever could be associated with other autoimmune diseases such as Ankylosing Spondylitis, Rheumatoid Arthritis, Polyarteritis Nodosa, Behcet disease, Systemic Lupus, Henoch-Schönlein Purpura, and Hashimoto’s Thyroiditis. Association of type 1 Diabetes Mellitus and Familial Mediterranean Fever has been newly reported in the medical literature, this is the third association of these two diseases described in the medical literature so far.

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Are systemic lupus erythematosus patients carrying MEFV gene less prone to renal involvement? Report of three cases and review of the literature

Cited by 8 publications

References 18 publications

The coexistence of familial Mediterranean fever (FMF) in systemic lupus erythematosus (SLE) patients – A cross sectional study

The coexistence of familial Mediterranean fever (FMF) in systemic lupus erythematosus (SLE) patients – A cross sectional study

Systemic Lupus Erythematosus with Familial Mediterranean Fever: Case Report and Review of Literature

A case report of a boy suffering from Type 1 Diabetes Mellitus and Familial Mediterranean Fever

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