Two Cases of Canine Histoplasmosis in Japan.

Sano, Ayako; Ueda, Yachiyo; Inomata, Tomo; Tamura, Miki; Ikeda, Teruo; Kamei, Katsuhiko; Kiuchi, Akio; Mikami, Yuzuru; Nishimura, Kazuko; Miyaji, Makoto

doi:10.3314/jjmm.42.229

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…Oral administration of itraconazole was effective in a previously reported skin case [7]. However, antifungal agents were not effective in either of the present cases, even amphotericin B, which was effective in an American case [42], failed.…”

Section: Discussioncontrasting

confidence: 44%

“…The sequence from Case 1 (AB220060) and the revised sequences from three previously reported cases (AB220056-59) [7 Á9] showed 100% identity to the GenBank sequence AB211551 of Ajellomyces capsulatus derived from a clinical isolate of H. capsulatum from a patient with disseminated histoplasmosis and HIV infection in Thailand. The sequence from Case 2 (AB220061) and the one from a previous case [7] (AB220055) showed more than 99% identity to AB211551. In addition, the identities of the sequences among autochthonous canine histoplasmosis in Japan were more than 98%.…”

Section: Resultsmentioning

confidence: 93%

“…The revised sequence from a previous case [7] consisted of 516 base pairs, while all other sequences consisted of 518 base pairs. The sequences of the ITS1/2 sequences from the present 2 cases and of 4 previous reported cases were closely related.…”

Section: Resultsmentioning

confidence: 99%

“…The infectious routes of the canine histoplasmosis in Japan were thought to be via external injuries such as trauma, mange and surgical operation for castrations [7], which is in contrast to the fact that inhalation is thought to be general route for the infection in endemic areas [5]. It was thought that case 1 and previously reported cutaneous cases might have been caused by external injuries, while case 2 might be suspected to be caused by both external injury and inhalation.…”

Section: Discussionmentioning

confidence: 98%

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Molecular epidemiology of canine histoplasmosis in Japan

Murata¹,

Sano²,

Ueda³

et al. 2007

Med Mycol

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A recent case of canine histoplasmosis, the first confirmed case of disseminated infection accompanied by carcinoma in Japan, was diagnosed by clinical characteristics, histopathological examination, chest radiographs, ocular fundoscopy and molecular biological data. The clinical manifestations were not limited to cutaneous symptoms but were referable to disseminated infection, similar to human autochthonous cases. The partial sequences of the internal transcribed spacer (ITS1/2) regions of the ribosomal DNA genes of this and other Japanese canine histoplasmosis strains were 99-100% identical to the sequence AB211551 derived from a human isolate in Thailand, and showed a close relationship to the sequences derived from Japanese autochthonous systemic and cutaneous human cases. The phylogenetic analysis of 97 sequences of the ITS1/2 region disclosed six genotypes. The genotypes derived from Japanese autochthonous human and dog cases belonged to the cluster consisting of Histoplasma capsulatum var. capsulatum and H. capsulatum var. farciminosum sequences, indicating that these varieties might cause not only cutaneous but also systemic histoplasmosis, regardless of their host species. The current status of the 3 varieties of Histoplasma capsulatum according to the host species remains a subject of further investigation.

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Section: Discussioncontrasting

confidence: 44%

Section: Resultsmentioning

confidence: 93%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

Molecular epidemiology of canine histoplasmosis in Japan

Murata¹,

Sano²,

Ueda³

et al. 2007

Med Mycol

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“…Recently, however, autochthonous cases have been reported in humans [13]. Seven cases of canine histoplasmosis have been reported in Japan [12,17,18,20,22]. In addition, Murata et al have compared canine cases with worldwide human and equine cases with respect to partial sequences on the internal transcribed spacer (ITS1/ 2) regions of the ribosomal DNA genes [17].…”

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confidence: 99%

First Case Report of Histoplasmosis in a Cat in Japan

Kobayashi

Tanaka²,

Asai³

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. Cytological, histopathological and immunohistochemical examinations were carried out on a presumed 10-year-old Japanese cat showing vomiting and emaciation. On cytologic examination of the mass of the upper abdominal cavity, many yeast-like organisms were detected in the macrophages. At necropsy, the upper part of colon was markedly dilated with a thickened wall. The lung did not show significant changes. Histologically, severe necrotic and granulomatous lesions were observed in the colon. In the colonic lesion, the cytoplasm of the macrophages contained yeast-like organisms with irregularly shaped dots, and the cell walls of these organisms were stained black by Grocott-Gomori methenamine-silver stain. Immunohistochemically, they were found to be positive for anti-histoplasma yeast antibody. This is the first report of feline histoplasmosis in Japan.

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