Two Base Pair Duplexes Suffice to Build a Novel Material

Abstract

Tetrahedral DNA hybrids with tetrakis(p-hydroxyphenyl)methane cores hybridize in a sequence-specific fashion at much higher temperatures than isolated linear duplexes. Dinucleotide DNA arms suffice to induce the formation of a solid at room temperature; this demonstrates the strength of multivalent binding. The graphic shows a view of a modeled assembly.

Encapsulating Active Pharmaceutical Ingredients in Self‐Assembling Adamantanes with Short DNA Zippers

“…Because such a high concentration of magnesium ions usually induces the precipitation of the hybrid,23, 24 this suggests that the known DNA‐binder can suppress the formation of the insoluble three‐dimensional network of the hybrid. Not surprisingly, cytochrome c, a hemeprotein involved in respiratory chain redox reactions in mitochondria of over 100 amino acid residues does not form an inclusion material with (CG) 4 TBA ( 1 ), but it also does not inhibit material formation at high magnesium concentration.…”

The Unlikely Surfactant: DNA as a Ligand for Single-Walled Carbon Nanotubes

“…Engaging them in sequence-specific base pairing interactions constitutes an important step towards nanoconstruction with carbon nanotubes. Since DNA is one of the most powerful materials for soft matter nanostructuring (Park et al, 2008;Nykypanchuk et al, 2008;Meng et al, 2009), and consequently, DNA nanostructing is one of the fastest growing fields of present-day science, (Niemeyer, 1999;Seeman, 2003;Gothelf and LaBean, 2005;Lu et al, 2008;Shin et al, 2009), we believe that harnessing the complexes the DNA and SWCNTs will lead to the discovery of fascinating new functional nanomaterials.…”

Fourfold Suzuki–Miyaura and Sonogashira Cross‐Coupling Reactions on Tetrahedral Methane and Adamantane Derivatives

“…[13,14] We have been interested in the synthesis of organic tectons and the resulting networks for a while now. [15] Here we report a systematic study on the fourfold Suzuki-Miyaura and Sonogashira cross-coupling reactions on common tetrahedral methane and adamantane core structures. Apart from compounds 3d, [12a,12c] 5d, [12af] 5f, [12b] 6c, [12r,12u] 7c [12o] and 10h, [12y,16] all synthesized compounds are new.…”