Two Antigenically Different Types of Macrophages

Montfort, Irmgard; Tamayo, Ruy Pérez

doi:10.3181/00379727-138-35862

Cited by 21 publications

(5 citation statements)

References 7 publications

(7 reference statements)

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“…The nonadherent cell population from each rat was counted, and the viability (by trypan blue exclusion), phagocytotic ability (37), pinocytotic ability (10), and morphological appearance (Wright-Giemsa stain) were determined. In selected cases, dichlorotriazinylaminofluorescein (DTAF)-labeled (3) F(ab)2 fragments of anti-alveolar macrophage serum (31) were used to confirm morphological and functional evidence of the absence of large numbers of macrophages in the final cell population.…”

Section: Murine Respiratory Mycoplasmosis In Ratsmentioning

confidence: 99%

Murine respiratory mycoplasmosis in F344 and LEW rats: evolution of lesions and lung lymphoid cell populations

Davis¹,

Thorp²,

Maddox³

et al. 1982

Infect Immun

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By comparison of two rat strains, LEW and F344, which are known to differ in susceptibility to Mycoplasma pulmonis respiratory disease, it was shown that differences in lesion severity and progression were associated with changes in lung lymphocyte populations. Lung lesions in LEW rats developed earlier after infection, became more severe, and were characterized by continued proliferation of all classes of lymphoid cells, T lymphocytes, B lymphocytes, and plasma cells, throughout the 120-day observation period. In contrast, lymphoid proliferation in F344 rats reached a plateau at 28 days and was restricted to an increase in T lymphocytes, immunoglobulin A (IgA)-bearing B lymphocytes, and IgA and IgG plasma cells. Although approximately 10 times as many IgG B cells and 4 times as many IgG plasma cells were found in infected LEW rats as compared with F344 rats, the specific anti-M. pulmonis IgG response in the two strains was roughly parallel. The same relationships held true, although to a lesser extent, for specific IgA antibody responses and cellular responses. Whereas lung lesions showed a tendency to resolve in F344 rats by 120 days, severe lesions persisted in LEW rats. The disparity between the cellular response and specific antibody response, the seemingly uncontrolled lymphocyte proliferation in LEW rats, and the mitogenic potential of M. pulmonis suggest that differences between LEW and F344 rats in lung lesion severity and progression are related to differences in the degree of nonspecific lymphocyte activation in the two strains, an imbalance in regulation of lymphocyte proliferation in LEW rats, or both.

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Section: Murine Respiratory Mycoplasmosis In Ratsmentioning

confidence: 99%

Murine respiratory mycoplasmosis in F344 and LEW rats: evolution of lesions and lung lymphoid cell populations

Davis¹,

Thorp²,

Maddox³

et al. 1982

Infect Immun

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“…There have been two successful attempts to classify macrophages on the bjisis of surface antigens. Montfort & Tamayo (1971) were able to produce a specific anti-rat-macrophage antibody in rabbits. Using a fluorescent label, they showed that the corresponding antigen was present on free macrophages but absent from fixed cells.…”

Section: The Diversity Of Macrophagesmentioning

confidence: 99%

T Cells, T Cell Recognition Structures, and the Major Histocompatibility Complex

Snell

1978

Immunological Reviews

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“…Monocytes appear to be the primary mediator of this suppressive effect in most individuals, as the efect can be removed by adherence or by the macrophage toxic agent carrageenan (7). There is also evidence for phenotypic and functional heterogeneity of macrophages (8,9).…”

mentioning

confidence: 99%

Suppressive Effect of Monocytes in Vitro in Patients with Carcinoma of the Uterine Cervix

Bjercke

Onsrud

Gaudernack

1986

Acta Obstet Gynecol Scand

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The adherent cell fraction (AdC) of human peripheral blood mononuclear cells (PBM) contains two cell types of opposing function in vitro. Dendritic cells (DC) act as antigen-presenting cells (APC) in vitro, while monocytes (Mo) have a suppressive effect on antigen activation of T cells. In this report we show that patients with cervical carcinoma have a significantly increased number of suppressive Mo compared with healthy controls. The T cell response to Herpes Simplex Virus (HSV-1) and PPD was about the same in the two groups, but after removal of Mo by adherence a significantly higher T cell response was seen among the patients with advanced stage (Figo stage IIb-IVa) compared with patients in early stage (Figo stage Ia-IIa) and healthy controls. These observations indicate that patients with cervical carcinoma have an increased number of T cells reactive with HSV, and normal DC function. The relative suppression expressed on a per Mo basis was the same in all groups, which indicates that the increased suppression in the patients was caused by an increased number of Mo, and not by changes in their activation state.

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Two Antigenically Different Types of Macrophages

Cited by 21 publications

References 7 publications

Murine respiratory mycoplasmosis in F344 and LEW rats: evolution of lesions and lung lymphoid cell populations

Murine respiratory mycoplasmosis in F344 and LEW rats: evolution of lesions and lung lymphoid cell populations

T Cells, T Cell Recognition Structures, and the Major Histocompatibility Complex

Suppressive Effect of Monocytes in Vitro in Patients with Carcinoma of the Uterine Cervix

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