Twin screw granulation — A literature review

Seem, Timothy Chan; Rowson, Neil A.; Ingram, Andrew; Huang, Zhaohui; Shen, Yu; Matas, Marcel de; Gabbott, Ian; Reynolds, Gavin K.

doi:10.1016/j.powtec.2015.01.075

Cited by 142 publications

(88 citation statements)

References 43 publications

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“…Recently, as the continuous manufacturing concept is introduced and discussed, implementation of a switch from batch granulation to continuous granulation has received attention. Continuous granulation has the advantage of high volume production with reduced equipment footprint, and control strategies which enable reduced process development time (Seem, Rowson et al, 2015). Among the continuous wet granulation methods, twin screw wet granulation (TSWG) is well-suited for pharmaceutical processes due to its process stability, flexible scale up, short residence time, and controlled throughput (Keleb, Vermeire et al, 2004; Plumb, 2005; Vervaet and Remon, 2005; Vercruysse, Córdoba Díaz et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

Liu

Galbraith

Ricart

et al. 2017

International Journal of Pharmaceutics

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In this study, the influence of key process variables (screw speed, throughput and liquid to solid (L/S) ratio) of a continuous twin screw wet granulation (TSWG) was investigated using a central composite face-centered (CCF) experimental design method. Regression models were developed to predict the process responses (motor torque, granule residence time), granule properties (size distribution, volume average diameter, yield, relative width, flowability) and tablet properties (tensile strength). The effects of the three key process variables were analyzed via contour and interaction plots. The experimental results have demonstrated that all the process responses, granule properties and tablet properties are influenced by changing the screw speed, throughput and L/S ratio. The TSWG process was optimized to produce granules with specific volume average diameter of 150 μm and the yield of 95% based on the developed regression models. A design space (DS) was built based on volume average granule diameter between 90 and 200 μm and the granule yield larger than 75% with a failure probability analysis using Monte Carlo simulations. Validation experiments successfully validated the robustness and accuracy of the DS generated using the CCF experimental design in optimizing a continuous TSWG process.

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Section: Introductionmentioning

confidence: 99%

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

Liu

Galbraith

Ricart

et al. 2017

International Journal of Pharmaceutics

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“…Thus, it was found that in order to obtain the smallest values of viscosity during dough kneading the distance between the working body pins should be l 1 …”

Section: Mathematical and Statistical Results Processing Of Working Bmentioning

confidence: 99%

“…As such, there is small variety between granulators and differences are typically limited to geometric constraints i.e. length, screw diameter and specific screw element geometry [1]. However, it is worth emphasizing that working bodies of existing machines have constant and unchanged geometric shape.…”

Section: Problem Statementmentioning

confidence: 99%

Simulation of Components Mixing in Order to Determine Working Bodies Rational Parameters

Stadnyk¹,

Vitenko²,

Dróździel³

et al. 2016

Adv. Sci. Technol. Res. J.

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One of important things in the production of vitally foods is bakery industry. The quality of baked goods can be achieved by improving the quality of dough kneading. In order to achieve this goal a new structure of the working body and methods of mathematical and computer modelling are offered, aimed to determine the working body design factors and visualize the process. Mathematical models of the dependency of dough viscosity from working body structural features and the frequency of its rotation are made. The obtained models are used to determine rational values of controlled parameters. It has been found that for wheat dough mixing the use of equipment with pin working bodies is more preferable. One of them -the main one -is larger in diameter, and two others -supporting ones -are smaller, able to ensure effective implementation of first and second stages of components mixing. The necessity of changing rotation direction of working bodies is substantiated. At the initial stage of mixing it is necessary to ensure larger diameter pin heating and at the stage of plasticization -vice versa -smaller diameter pins heating.

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“…1 This includes the design of appropriate measurement systems for the real-time monitoring of its producing unit operations. 1 This includes the design of appropriate measurement systems for the real-time monitoring of its producing unit operations.…”

Section: Introductionmentioning

confidence: 99%

Liquid‐to‐solid ratio control as an advanced process control solution for continuous twin‐screw wet granulation

et al. 2018

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Assuring compliance of intermediate and final quality attributes in a continuous pharmaceutical manufacturing campaign is of utmost importance. Application of corrective actions might be required in real‐time. This work exemplifies the steps needed to identify a linear pulse transfer function for the dynamic behavior of the granule liquid‐to‐solid ratio (%w/w) at the end of the granulation unit of a commercial ConsiGmaTM‐25 production line. Near‐infrared spectroscopy was used to monitor the granule composition in‐line. The outcome for both the tracking and regulator problem using either conventional or model predictive control was implemented and evaluated. Dynamic setpoints were correctly followed and an RMSE of 0.25%w/w with respect to the setpoint was obtained when inducing artificial disturbances. Important practical challenges were also tackled. Examples are fouling, computational limitations, and the limited flexibility of the automation software. Applying the proposed advanced process control solution offers an answer to upstream material flow rate deviations. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2500–2514, 2018

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Twin screw granulation — A literature review

Cited by 142 publications

References 43 publications

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

Optimization of critical quality attributes in continuous twin-screw wet granulation via design space validated with pilot scale experimental data

Simulation of Components Mixing in Order to Determine Working Bodies Rational Parameters

Liquid‐to‐solid ratio control as an advanced process control solution for continuous twin‐screw wet granulation

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