Twenty years of research on silica‐based chiral stationary phases

Cancelliere, Giovanna; D’Acquarica, Ilaria; Gasparrini, Francesco; Maggini, Michele; Misiti, D.; Villani, Claudio

doi:10.1002/jssc.200500517

Cited by 34 publications

(21 citation statements)

References 67 publications

(80 reference statements)

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“…A plethora of interesting and potentially valuable CSPs have been produced and evaluated in academic laboratories in the past, but, because of cost, have never been realistic candidates for commercialization. A few examples from the La Sapienza group [22][23][24] may serve to whet the appetite for a future in which the microscale chiral HPLC, or chip-HPLC is widespread, and when synthetically complex and highly specialized stationary phases can become viable commercial products.…”

Section: New Paradigm For Commercialization Of Complex Cspsmentioning

confidence: 98%

Microscale chiral HPLC in support of pharmaceutical process research

Welch

2008

Chirality

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Some recent developments in the use of microscale chiral HPLC for supporting pharmaceutical process research are reviewed, including multiparallel high throughput analysis to support high throughput experimentation studies, rapid multiparallel chromatographic method development, and on-line reaction monitoring. Green chemistry advantages of the approach include greatly reduced solvent consumption, waste generation, and stationary phase requirement relative to conventional chiral HPLC.

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Section: New Paradigm For Commercialization Of Complex Cspsmentioning

confidence: 98%

Microscale chiral HPLC in support of pharmaceutical process research

Welch

2008

Chirality

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“…Another item of a large market is chiral stationary phases on which many review articles have been published. [73][74][75][76][77][78][79] Chiral stationary phases bear a great importance in pharmaceutical fields. A variety of chiral ligand modified silica particles have been commercialized.…”

Section: Modification Of Silica Particlesmentioning

confidence: 99%

Porous Silica Particles As Chromatographic Separation Media: A Review

Cheong¹

2014

Bulletin of the Korean Chemical Society

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Porous silica particles are the most prevailing raw material for stationary phases of liquid chromatography. During a long period of time, various methodologies for production of porous silica particles have been proposed, such as crashing and sieving of xerogel, traditional dry or wet process preparation of conventional spherical particles, preparation of hierarchical mesoporous particles by template-mediated pore formation, repeated formation of a thin layer of porous silica upon nonporous silica core (core-shell particles), and formation of specific silica monolith followed by grinding and calcination. Recent developments and applications of useful porous silica particles will be covered in this review. Discussion on sub-3 µm silica particles including nonporous silica particles, carbon or metal oxide clad silica particles, and molecularly imprinted silica particles, will also be included. Next, the individual preparation methods and their feasibilities will be collectively and critically compared and evaluated, being followed by conclusive remarks and future perspectives.

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“…The basic principle of chiral separation is that the chiral selector interacts differently with the enantiomers of a racemic or enantioenriched mixture to form transient diastereoisomeric species of different stability, and this fine distinction leads to the separation of enantiomers during elution. This topic has also produced a huge number of papers and the readers are referred to the previous reviews for more knowledge on this field [70][71][72][73] .…”

Section: Introductionmentioning

confidence: 99%

Chiral Metal-Organic Porous Materials: Synthetic Strategies and Applications in Chiral Separation and Catalysis

Kim

Banerjee

Yoon

et al. 2009

Topics in Current Chemistry

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In the light of growing demand for chiral purity in biological and chemical processes, the synthesis of chiral metal-organic porous materials (CMOPMs) have become immensely important because of their potential applications in chiral separation and asymmetric catalysis. In this chapter, the synthetic strategies for CMOPMs are discussed briefly keeping the focus on their applications. Two distinct approaches have been taken to synthesize a wide variety of chiral structures with different topologies and accessible cavities. Several CMOPMs have shown catalytic activity and enantioselectivity toward a number of chemical transformations. On many occasions, the chiral pores of the MOPMs have been utilized in order to achieve separation of enantiomers from racemates. Recent applications of homochiral MOPMs in heterogeneous asymmetric catalysis and chiral separations are also presented here.

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Twenty years of research on silica‐based chiral stationary phases

Cited by 34 publications

References 67 publications

Microscale chiral HPLC in support of pharmaceutical process research

Microscale chiral HPLC in support of pharmaceutical process research

Porous Silica Particles As Chromatographic Separation Media: A Review

Chiral Metal-Organic Porous Materials: Synthetic Strategies and Applications in Chiral Separation and Catalysis

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