Twenty-four hour intragastric acidity and plasma gastrin concentration profiles in female and male subjects

Abstract

1. Simultaneous 24 h intragastric acidity and plasma gastrin concentration profiles were determined in 35 healthy young women and 96 healthy young men. 2. The females had a consistently lower median hourly intragastric acidity, and a higher median hourly plasma gastrin concentration, throughout the 24 h. 3. The 24 h integrated intragastric acidity was significantly lower in the female group (females, 485 mmol.h.l-1; males, 842 mmol.h.l-1. P less than 0.001). The 24 h integrated plasma gastrin concentration was significantly higher in the female group (females, 407 pmol.h.l-1; males, 185 pmol.h.l-1; P less than 0.001).

Comparison of the effects of immediate‐release omeprazole oral suspension, delayed‐release lansoprazole capsules and delayed‐release esomeprazole capsules on nocturnal gastric acidity after bedtime dosing in patients with night‐time GERD symptoms

“…Recent findings suggest that reflux episodes occur primarily during the first half of the sleeping period 1 . This is consistent with the circadian rhythm of gastric acid secretion that is characterized by increasing acid output in the late evening, reaching a maximum in the early night‐time hours and diminishing towards the early morning 2,3 . This rhythm has been described in healthy subjects, even when receiving a proton pump inhibitor (PPI) twice daily, 4 and in patients with gastro‐oesophageal reflux disease (GERD) 5…”

“…1 This is consistent with the circadian rhythm of gastric acid secretion that is characterized by increasing acid output in the late evening, reaching a maximum in the early night-time hours and diminishing towards the early morning. 2,3 This rhythm has been described in healthy subjects, even when receiving a proton pump inhibitor (PPI) twice daily, 4 and in patients with gastro-oesophageal reflux disease (GERD). 5 Gastro-oesophageal reflux disease is generally considered to be one of the most prevalent conditions affecting the gastrointestinal (GI) tract.…”

24-h Recording of Intragastric pH: Technical Aspects and Clinical Relevance

“…1). After taking weight, length and body fat into account, this difference between men and women was preserved (52,53). Twenty-four-hour intragastric pH recording also showed a significantly lower gastric acidity in women (18).…”

“…Using aspiration techniques, Prewett et al investigated 24-h acidity profiles in healthy young women and healthy age-matched men (52). They found a significantly higher 24-h intragastric acidity in men (842 versus 485 mmol h À1 l À1 ) (Fig.…”

Measurement of gastric pH in ambulatory esophageal pH monitoring

“…When 1968-1973 1971 assessed in the fasting condition, a one-time spot measurement of gastric pH does appear to have a significant influence on the results of prolonged esophageal pH monitoring. Previous workers have studied the factors influencing acid secretion of the stomach [9][10][11]. There is circadian variability in acid secretion, in addition to regional differences within the stomach.…”