Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals

Stanhope, Kimber L.; Griffen, Steven C.; Bair, Brandi R; Swarbrick, Michael M.; Keim, Nancy L.; Havel, Peter J.

doi:10.1093/ajcn/87.5.1194

Cited by 196 publications

(166 citation statements)

References 42 publications

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“…The level of -hydroxybutyric acid ( -HB) was meaconcentrations 4,5) , and postprandial hyperlipidemia is widely accepted to be a major risk factor for coronary heart disease, as first proposed by Zilversmit 6) . Furthermore, the habitual consumption of fructose has also been reported to increase the deposition of visceral adipose tissue 7) . In our previous study, the serum concentrations of TG, remnant-like particle (RLP)-TG and apolipoprotein B-48 (apoB48) were significantly increased following the ingestion of a moderate amount of fructose (0.5 g/kg body weight) combined with fat compared to that observed after the ingestion of glucose in healthy young women, even in a single ingestion, demonstrating that fructose markedly exacerbates postprandial exogenous lipidemia 8) .…”

Section: Biochemical Analysismentioning

confidence: 99%

The Ingestion of a Fructose-Containing Beverage Combined with Fat Cream Exacerbates Postprandial Lipidemia in Young Healthy Women

Saito

Kato

Yoshida

et al. 2015

JAT

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Aim:To investigate the acute effects of the ingestion of a fructose-containing beverage combined with fat on postprandial lipoprotein metabolism. Methods: Twelve young healthy Japanese women with apolipoprotein E phenotype 3/3 were enrolled in this study. At each of four sessions, the subjects ingested one of four sugar beverages containing fructose and/or glucose (total: 0.5 g/kg body weight) combined with OFTT cream (1 g/kg, 0.35 g/kg as fat) in a randomized crossover design. The four sugar beverages were as follows: 100% (w/w) fructose (F100), 90% fructose 10% glucose (F90G10), 55% fructose 45% glucose (F55G45) and 100% glucose (G100). Venous blood samples were obtained at baseline and 0.5, one, two, four and six hours after ingestion. Results: The serum concentrations of TG in the F100, F90G10 and F55G45 trials were significantly higher than each fasting value at two and four hours, and returned to baseline at six hours, except in the F100 trial. The concentrations at four hours and the incremental areas under the curve for the hepatic triglyceride-rich lipoprotein-triglyceride (VLDL-TG TM ) levels in the F100 and F90G10 trials were significantly higher and larger, respectively, than those observed in the G100 trial. Meanwhile, the concentrations of RLP-TG and apolipoprotein B-48 peaked at two hours in the G100 trial, versus four hours in the other trials, and did not return to baseline at six hours, except in the G100 trial. At four hours, the apoB48 tended to be higher in the F100 trial than in the G100 trial.

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Section: Biochemical Analysismentioning

confidence: 99%

The Ingestion of a Fructose-Containing Beverage Combined with Fat Cream Exacerbates Postprandial Lipidemia in Young Healthy Women

Saito

Kato

Yoshida

et al. 2015

JAT

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“…Based on animal experiments, an increased VLDL-triacylglycerol secretion is also likely to be involved [28]. The increase in plasma triglyceride induced by fructose is significantly blunted in females, which suggests that female sex hormones may exert a protective effect [29,30]. In humans, a high-fructose, hypercaloric diet leads to ectopic fat deposition in liver cells and skeletal muscle in humans already after a 1-wk period [31].…”

Section: What Are the Mechanisms Responsible For Fructose-induced Metmentioning

confidence: 99%

“…In humans, it has been shown that fructose, when substituted for starch, increases plasma triglycerides [44]. It has also been shown that, in obese hyperinsulinemic women, administration of equivalent amounts of pure fructose, sucrose, and HFCS led to identical increases in plasma triglyceride, although the intake of fructose was about 50% less with sucrose and HFCS compared to pure fructose [30]. In normal weight and obese women overfed for 4 d with 50% glucose or fructose above their energy requirement, de novo lipogenesis was found to be identical under both conditions.…”

Section: Are the Effects Of Fructose Different From Those Of Glucose?mentioning

confidence: 99%

Fructose and metabolic diseases: New findings, new questions

et al. 2010

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There has been much concern regarding the role of dietary fructose in the development of metabolic diseases. This concern arises from the continuous increase in fructose (and total added caloric sweeteners consumption) in recent decades, and from the increased use of high-fructose corn syrup (HFCS) as a sweetener. A large body of evidence shows that a high-fructose diet leads to the development of obesity, diabetes, and dyslipidemia in rodents. In humans, fructose has long been known to increase plasma triglyceride concentrations. In addition, when ingested in large amounts as part of a hypercaloric diet, it can cause hepatic insulin resistance, increased total and visceral fat mass, and accumulation of ectopic fat in the liver and skeletal muscle. These early effects may be instrumental in causing, in the long run, the development of the metabolic syndrome. There is however only limited evidence that fructose per se, when consumed in moderate amounts, has deleterious effects. Several effects of a high-fructose diet in humans can be observed with high-fat or high-glucose diets as well, suggesting that an excess caloric intake may be the main factor involved in the development of the metabolic syndrome. The major source of fructose in our diet is with sweetened beverages (and with other products in which caloric sweeteners have been added). The progressive replacement of sucrose by HFCS is however unlikely to be directly involved in the epidemy of metabolic disease, because HFCS appears to have basically the same metabolic effects as sucrose. Consumption of sweetened beverages is however clearly associated with excess calorie intake, and an increased risk of diabetes and cardiovascular diseases through an increase in body weight. This has led to the recommendation to limit the daily intake of sugar calories.Pure, white, and deadly: the dark side of sugar was suspected many years ago, when an association between sugar consumption and coronary heart diseases was recognized and emphasized by John Yudkin [1]. Sugar, a natural sweetener obtained from either sugar cane or beets, is a disaccharide composed of one glucose molecule linked through an α1-4 glycoside bond to a fructose molecule. Fructose, besides contributing to half the total content of sugar, can also be found as a hexose in fruits and honey. More recently, sweeteners started to be produced from corn through starch isolation and hydrolysis to glucose, followed by enzymatic isomerization of part of the glucose into fructose [2,3]. The resulting mixture, known as high-fructose corn syrup (HFCS), has several industrial advantages over sugar, the most important being its low price, and has progressively replaced sugar consumption in North America over the past 30 years.Fructose metabolism has been reviewed extensively elsewhere [4][5][6] and will be only briefly outlined here. In the gut, fructose is transported by specific transporters, GLUT5 [7,8]. In some subjects, fructose absorption is quantitatively limited, and some malabsorption occurs when lar...

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“…Insulin resistance was evaluated according to the homeostasis model assessment for insulin resistance (HOMA-IR) 15) . The hemoglobin A1c (HbA1c) level was measured using a latex agglutination method (Fujirebio) and expressed the fructose component 5) . Some studies have shown that the plasma concentration of TG increases significantly when fructose is ingested simultaneously with fat compared to that observed following fat intake only 6,7) .…”

Section: Biochemical Analysismentioning

confidence: 99%

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

Saito

Kagaya

Suzuki

et al. 2013

JAT

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Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals

Abstract: Sucrose and HFCS do not have substantially different short-term endocrine/metabolic effects. In male subjects, short-term consumption of sucrose and HFCS resulted in postprandial TG responses comparable to those induced by fructose.

Cited by 196 publications

References 42 publications

The Ingestion of a Fructose-Containing Beverage Combined with Fat Cream Exacerbates Postprandial Lipidemia in Young Healthy Women

The Ingestion of a Fructose-Containing Beverage Combined with Fat Cream Exacerbates Postprandial Lipidemia in Young Healthy Women

Fructose and metabolic diseases: New findings, new questions

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

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