Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

The Ingestion of a Fructose-Containing Beverage Combined with Fat Cream Exacerbates Postprandial Lipidemia in Young Healthy Women

“…Moreover, in all but the G100 trial, the concentration of apoB48 did not return to baseline at six hours. These results suggest the presence of delayed intestinal absorption of dietary fat and/or the secretion of CM from the intestine in addition to the delayed removal of CM and CM-R, consistent with our previous findings 8) , although the mechanisms underlying these changes are not clear.…”

“…We previously demonstrated that the ingestion of fructose combined with fat leads to a significantly higher rise (with a delayed peak) in the serum concentrations of TG, RLP-TG, RemL-C and apoB48 compared to the ingestion of glucose with fat, suggesting a delay in the removal of intestinal TG-rich lipoproteins (TRL), namely chylomicron (CM) and chylomicronremnant (CM-R) 8) . In that study, we examined the effects of pure fructose combined with fat on postprandial lipoprotein metabolism.…”

“…Furthermore, the habitual consumption of fructose has also been reported to increase the deposition of visceral adipose tissue 7) . In our previous study, the serum concentrations of TG, remnant-like particle (RLP)-TG and apolipoprotein B-48 (apoB48) were significantly increased following the ingestion of a moderate amount of fructose (0.5 g/kg body weight) combined with fat compared to that observed after the ingestion of glucose in healthy young women, even in a single ingestion, demonstrating that fructose markedly exacerbates postprandial exogenous lipidemia 8) .…”

“…The postprandial metabolism was quantified by calculating the incremental area under the curve ( AUC), which was defined as the difference between the area under the curve and the area below the baseline (0 hours) concentration from zero to six hours, as previously described 8) .…”

“…In each test trial, the subjects ingested one of four beverages containing fructose (F) and/or glucose (G) (total: 0.5 g/kg body weight) combined with oral fat tolerance test (OFTT) cream (Jomo, Takasaki, Japan; 1 g/kg, 0.35 g/kg as fat) in a randomized crossover design. The OFTT cream was used as previously described 8,[10][11][12][13] . The four beverages were prepared as follows: F100: 100% (w/w) fructose (Nisshin Seito, Tokyo, Japan), F90G10: 90% fructose 10% glucose (Fuso Pharmaceutical, Osaka, Japan), F55G45: 55% fructose 45% glucose and G100: 100% glucose.…”