Twenty-four-hour ambulatory heart rate and organ damage in primary hypertension

Fácila, Lorenzo; Pallarés, Vicente; Peset, Ana; Pérez, Manuel Gorostidi; Gil, Vicente; Montagud, Vicente; Bellido, V.; Bertomeu‐González, Vicente; Redón, Josep

doi:10.3109/08037050903525103

Cited by 18 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fácila et al [17] studied a sample of 566 hypertensive patients, assessing HR by ABPM during activity and resting periods, and analyzing the association with the presence of TOD. The prevalence of TOD was found to be 12.4%, versus 46.7% in our study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Office and 24-hour heart rate and target organ damage in hypertensive patients

García-García

Gómez‐Marcos

Patino-Alonso

et al. 2012

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundWe investigated the association between heart rate and its variability with the parameters that assess vascular, renal and cardiac target organ damage.MethodsA cross-sectional study was performed including a consecutive sample of 360 hypertensive patients without heart rate lowering drugs (aged 56 ± 11 years, 64.2% male). Heart rate (HR) and its standard deviation (HRV) in clinical and 24-hour ambulatory monitoring were evaluated. Renal damage was assessed by glomerular filtration rate and albumin/creatinine ratio; vascular damage by carotid intima-media thickness and ankle/brachial index; and cardiac damage by the Cornell voltage-duration product and left ventricular mass index.ResultsThere was a positive correlation between ambulatory, but not clinical, heart rate and its standard deviation with glomerular filtration rate, and a negative correlation with carotid intima-media thickness, and night/day ratio of systolic and diastolic blood pressure. There was no correlation with albumin/creatinine ratio, ankle/brachial index, Cornell voltage-duration product or left ventricular mass index. In the multiple linear regression analysis, after adjusting for age, the association of glomerular filtration rate and intima-media thickness with ambulatory heart rate and its standard deviation was lost. According to the logistic regression analysis, the predictors of any target organ damage were age (OR = 1.034 and 1.033) and night/day systolic blood pressure ratio (OR = 1.425 and 1.512). Neither 24 HR nor 24 HRV reached statistical significance.ConclusionsHigh ambulatory heart rate and its variability, but not clinical HR, are associated with decreased carotid intima-media thickness and a higher glomerular filtration rate, although this is lost after adjusting for age.Trial RegistrationClinicalTrials.gov: NCT01325064

show abstract

Section: Discussionmentioning

confidence: 99%

“…In addition, proteinuria values may be increased in subjects with an elevated HR, even in normotensive individuals [15]. The association of HR (both sleep and awake HR) and its variability with vascular, renal and cardiac target organ damage (TOD) in a cohort of hypertensive patients has not been clearly established [16,17]. …”

Section: Introductionmentioning

confidence: 99%

Office and 24-hour heart rate and target organ damage in hypertensive patients

García-García

Gómez‐Marcos

Patino-Alonso

et al. 2012

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…24 In a Japanese study, subjects with a higher HR had higher frequencies of proteinuria, although they were all normotensive, indicating that subjects with elevated HR are likely to have early-stage vascular damage, even if they are normotensive. 25 In hypertensive patients assessed with 24-hour ambulatory monitoring, Facila et al 26 showed that patients with nocturnal HR Ն65 bpm (41.3%) had a higher prevalence of target organ damage compared with those with HR Ͻ65 bpm. HR was also shown to be a main determinant of arterial stiffness.…”

Section: Hr As a Determinant Of Target Organ Damagementioning

confidence: 99%

Role of Elevated Heart Rate in the Development of Cardiovascular Disease in Hypertension

Palatini

2011

Hypertension

View full text Add to dashboard Cite

T hat elevated heart rate (HR) is a risk factor for cardiovascular morbidity and mortality in healthy people as well as in patients with cardiac diseases is supported by numerous epidemiological association studies. 1-4 Increased HR has been recognized as a negative prognostic factor independent of many other clinical parameters that can influence the HR, including physical activity scores, left ventricular function, or use of ␤-blockers. Thus, HR appears to satisfy all epidemiological criteria for being considered as a true risk factor, and its predictive value for cardiovascular disease appeared to be as strong as that of most important cardiovascular risk factors. This is particularly true for the results obtained in hypertensive patients. Elevated HR is a common feature among hypertensive individuals. 1 Among the young hypertensive subjects participating in the HAR-VEST study, Ͼ15% had a baseline resting HR Ն85 bpm and 27% had a HR Ն80 bpm. 5 According to the Tensiopulse study, which evaluated 38 145 patients cared for by 2000 general practitioners all across Italy, Ͼ30% of the hypertensive patients had a resting HR Ն80 bpm. 6 In a large French population, untreated hypertensive subjects had approximately a 6-bpm faster HR than normotensive individuals. 7 Elevated HR is frequently associated with high blood pressure (BP) and metabolic disturbances and increases the risk of new onset hypertension and diabetes. 1 Many experimental data obtained both in animals and in human beings support the importance of HR as a true risk factor for atherosclerosis and cardiovascular disease, providing convincing evidence for this pathogenetic mechanism. 1-3 The pathogenetic connection between HR and cardiovascular disease has been discussed in several reports [1][2][3]8,9 and is beyond the scope of this review. High HR as a Precursor of Hypertension, Obesity, and DiabetesNumerous studies have demonstrated that tachycardia is frequently associated with hypertension in both sexes and that this relationship is present at all ages and all BP levels. 1,10 This association remains significant even after taking into account several confounding factors, such as body mass index (BMI), age, and metabolic parameters. HR has also emerged as a risk factor for future development of hypertension. The first study to demonstrate a longitudinal relationship between HR and BP dates back to 1945, when an American army doctor 11 observed that transient tachycardia detected during routine examination could predict the development of stable hypertension later in life. The predictive power of HR for the development of hypertension has been confirmed in numerous other studies. In a Japanese cohort, normotensive men and women with an HR in the upper quartile had a 60% higher 3-year risk of developing hypertension than persons in the bottom quartile. 12 This longitudinal association has been demonstrated not only for baseline HR but also for the change in HR over time. In the HARVEST study, both baseline and follow-up HRs were potent predictors of subs...

show abstract

“…The ABP-International study found in 7600 untreated patients with hypertension that every 10 bpm of HR increase during nighttime could be associated with 13% of increased risk of cardiovascular events [15]. Another study in 566 patients with hypertension showed that nighttime HR values above 65 bpm could be associated with the presence of target organ damage [16].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Blood Pressure and Heart Rate Circadian Rhythms in Normotensive and Hypertensive Subjects

Silveri

Accardo

Pascazio³

2018

2018 Computing in Cardiology Conference (CinC)

View full text Add to dashboard Cite

This paper focuses on the relationship between blood pressure (BP) and heart rate (HR) during 24 hours in 423 normotensive (NO) and 205 hypertensive (HE) subjects. Although considerable knowledge has been gained about BP and HR signals, their relationship over 24 hours has never been completely described. By using a Holter Blood Pressure Monitor, it was possible to record BP and HR for 24 hours. Systolic, Diastolic and Mean BP in both NO and HE subjects showed four different time intervals presenting well-defined trends The results demonstrated that changes in HR present closely parallel changes in BP with a marked reduction of both signals during nocturnal rest. On the contrary, in the period between 15:30 and 19:30, HR and BP showed an inverse relationship with decreasing heart rate and increasing blood pressure.

show abstract

Twenty-four-hour ambulatory heart rate and organ damage in primary hypertension

Cited by 18 publications

References 24 publications

Office and 24-hour heart rate and target organ damage in hypertensive patients

Office and 24-hour heart rate and target organ damage in hypertensive patients

Role of Elevated Heart Rate in the Development of Cardiovascular Disease in Hypertension

Relationship Between Blood Pressure and Heart Rate Circadian Rhythms in Normotensive and Hypertensive Subjects

Contact Info

Product

Resources

About