“…Features that define asthma in humans, including eosinophilic bronchial inflammation, spontaneous and reversible bronchoconstriction, smooth muscle hypertrophy, and mucus gland hyperplasia, are also hallmark features of naturally occurring asthma in cats [23,24,25]. The basis of these pathologic changes in both feline and human atopic asthma is believed to involve a type I hypersensitivity reaction to inhaled allergen that is characterized by a Th2 lymphocyte polarized response, promoting the morphologic changes in the pulmonary airways including tissue eosinophilia, goblet cell hyperplasia, epithelial cell and smooth muscle proliferation, subepithelial fibrosis, and mast cell accumulation [23,26,27].…”