Tussilago farfara, coltsfoot

Tobyn, Graeme

doi:10.1016/b978-0-443-10344-5.00035-5

Cited by 3 publications

(3 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggested that the problem of the case area could be linked to the special water source [ 260 ]. Subsequent clinical, laboratory, toxicological, and histopathologic studies classified the fatal liver disease as HSOS due to PAs [ 261 ] contaminating water from the unprotected well [ 262 ], in which the PA-containing plant Ageratum sp. abundantly thrived [ 263 ].…”

Section: Subtropical and Tropical Pa-hsos Outbreaksmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The Update

Teschke

Noudeng

Quan

et al. 2021

IJMS

View full text Add to dashboard Cite

Saturated and unsaturated pyrrolizidine alkaloids (PAs) are present in more than 6000 plant species growing in countries all over the world. They have a typical heterocyclic structure in common, but differ in their potential toxicity, depending on the presence or absence of a double bond between C1 and C2. Fortunately, most plants contain saturated PAs without this double bond and are therefore not toxic for consumption by humans or animals. In a minority of plants, however, PAs with this double bond between C1 and C2 exhibit strong hepatotoxic, genotoxic, cytotoxic, neurotoxic, and tumorigenic potentials. If consumed in error and in large emouns, plants with 1,2-unsaturated PAs induce metabolic breaking-off of the double bonds of the unsaturated PAs, generating PA radicals that may trigger severe liver injury through a process involving microsomal P450 (CYP), with preference of its isoforms CYP 2A6, CYP 3A4, and CYP 3A5. This toxifying CYP-dependent conversion occurs primarily in the endoplasmic reticulum of the hepatocytes equivalent to the microsomal fraction. Toxified PAs injure the protein membranes of hepatocytes, and after passing their plasma membranes, more so the liver sinusoidal endothelial cells (LSECs), leading to life-threatening hepatic sinusoidal obstruction syndrome (HSOS). This injury is easily diagnosed by blood pyrrolizidine protein adducts, which are perfect diagnostic biomarkers, supporting causality evaluation using the updated RUCAM (Roussel Uclaf Causality Assessment Method). HSOS is clinically characterized by weight gain due to fluid accumulation (ascites, pleural effusion, and edema), and may lead to acute liver failure, liver transplantation, or death. In conclusion, plant-derived PAs with a double bond between C1 and C2 are potentially hepatotoxic after metabolic removal of the double bond, and may cause PA-HSOS with a potential lethal outcome, even if PA consumption is stopped.

show abstract

Section: Subtropical and Tropical Pa-hsos Outbreaksmentioning

confidence: 99%

“… Photography of PA-containing plants. All pictures above show PA-containing plants mentioned in the text of this manuscript and are obtained from open access publications as referenced [ 37 , 38 , 262 , 263 , 264 , 265 , 266 , 267 ]. Symphytum officinale (syn.…”

Section: Figurementioning

confidence: 99%

Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The Update

Teschke

Noudeng

Quan

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…Tussilago farfara is included in the pharmacopeias of 15 countries, and it is used in Russia, China, Turkey, Poland, the Balkan states, Germany, and other countries [ 17 ]. Coltsfoot is described in the literature as “nature’s best herb for the lungs” [ 18 ]. Research into the amino acid composition of coltsfoot leaves revealed a high arginine concentration, which positively effects the immune system [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Responses of Medicinal Plant Tussilago farfara L. to Elevated Heavy Metal Concentrations in Soils of Urban Areas

Petukhov

Кремлева

Петухова

et al. 2021

Toxics

View full text Add to dashboard Cite

This study was conducted in Tyumen (Russian Federation) to establish the effects of heavy metals’ (Cu, Zn, Fe, Mn, Pb, and Cd) accumulation in soil and coltsfoot, as well as plants’ biochemical responses to such an accumulation. The mobile and acid-soluble heavy metal fractions in soils, and the heavy metal contents in plants, were determined by atomic absorption spectrophotometry. The Cu, Zn, Fe, Mn, and Pb concentrations in soils exceeded background values. Pb content at the battery manufacturing plant was above the maximum permitted concentration. The percentages of the mobile heavy metal fractions decreased in the following order: Mn > Zn > Cu > Fe. The greatest heavy metal accumulation in soils and plants was found at the battery manufacturing and metallurgical plants examined in our study. Heavy metals’ accumulation in the aboveground part of Tussilago farfara decreased in the following order: Fe > Zn > Cu > Mn > Pb > Cd. The accumulation of heavy metals stimulated the synthesis of photosynthetic pigments by 6–30%. Heavy metals provoked oxidative stress in cells, increasing the concentration of lipid peroxidation in products by up to 80%. Plant phenolics and flavonoids in the urban area of our study decreased compared to those in the control by 1.05, reaching up to 6.5 times. The change in coltsfoot catalase activity both increased and declined. Biochemical responses and heavy metal accumulation in coltsfoot from urban areas limit its use for medicinal purposes.

show abstract

A LC–ESI–MS/MS analysis procedure coupled with solid phase extraction and MeOH extraction method for determination of pyrrolizidine alkaloids in Tussilago farfara and Lithospermi erythrorhzion

Jeong

Choi

et al. 2021

Appl Biol Chem

View full text Add to dashboard Cite

Pyrrolizidine alkaloids (PAs) that are plant toxin naturally produced for protection against herbivores in some plant families. They are associated with the potential hepatotoxic and carcinogenic diseases serious hepatic disease in humans and animals. As the concern of human health risk posed by exposure to PAs has been gradually increased, precise and reliable analysis is required for monitoring PAs. The present study developed a new and simple pretreatment using 50% MeOH (methanol) for quantification analysis of the PAs contained with high content in the herbal medicines. Another pretreatment method using cation-ion exchange solid-phase extraction (MCX-SPE) was employed for determining most of the PAs that are not contained in the herbal medicines. That is, the proposed LC–MS/MS method coupled with MCX-SPE extraction and 50% MeOH extraction method was developed. And to evaluate the reliability of its application for Farfarae Flos and Lithospermi Radix, a validation study was conducted. In addition, monitory study was performed with ten samples in each herbal medicine. As a result, the proposed method had good linearity with r2 ≥ 0.997. Also, the recoveries indicated to be in the ranges of 70.4–118.0% for the Farfarae Flos, 70.2–119.7% for the Lithospermi Radix. In two herbal medicines, the intra-day precision was revealed to satisfy the reference criteria in most of the PAs. In monitoring results, most of the PAs were not contained in two herbal medicines, whereas a part of PAs revealed to have high concentration in Farfarae Flos and Lithospermi Radix. The proposed method is considered as a simple and reliable method to quantify 28 PAs present in two herbal medicines. Especially, the simple MeOH extraction method seems to be available for quantification analysis of certain PAs in herbal medicines with high content.

show abstract

Tussilago farfara, coltsfoot

Cited by 3 publications

References 27 publications

Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The Update

Metabolic Toxification of 1,2-Unsaturated Pyrrolizidine Alkaloids Causes Human Hepatic Sinusoidal Obstruction Syndrome: The Update

Biochemical Responses of Medicinal Plant Tussilago farfara L. to Elevated Heavy Metal Concentrations in Soils of Urban Areas

A LC–ESI–MS/MS analysis procedure coupled with solid phase extraction and MeOH extraction method for determination of pyrrolizidine alkaloids in Tussilago farfara and Lithospermi erythrorhzion

Contact Info

Product

Resources

About