“…Many patients have classic 45,X karyotypes, but frequently patients have another cell line containing 2 normal Xs or a normal X and a structurally abnormal X or Y chromosome. 16 More than 90% of patients with Turner syndrome have short stature, mani-fest premature ovarian failure, and are at high risk for various phenotypic abnormalities (eg, high palate, nail dysplasia, low posterior hairline, widely spaced nipples, webbed neck, and low-set or malrotated ears), as well as other medical problems such as cardiovascular defects, skeletal anomalies, and autoimmune disorders. 17 Patients with Turner syndrome frequently are prescribed recombinant human growth hormone (rhGH) therapy to increase their growth velocity and final adult height.…”